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Haemodynamic effects of combined alpha- and beta-adrenoreceptor blockade after intravenous labetalol in hypertensive patients at rest and during exercise.
Br J Clin Pharmacol. 1976 Aug; 3(4 Suppl 3):725-8.BJ

Abstract

1 The haemodynamic effects of labetalol 50 mg intravenously were studied in 13 hypertensive patients at rest in the supine and upright positions and during exercise using percutaneous right heart and brachial artery catheterization. 2 Labetalol induced immediate significant reductions in systolic and diastolic blood pressures in all conditions. 3 Heart rate, stroke volume and cardiac output were not significantly altered in the supine position at rest but were significantly reduced in the upright position. In addition systemic vascular resistance was significantly reduced. 4 During exercise, heart-rate, cardiac output and vascular resistance were significantly reduced; stroke volume was increased. Left ventriclac filling pressures were unchanged both at rest and during exercise. 5 It was concluded that these changes resulted from blockade to both alpha- and beta-adrenoreceptor.

Authors

Koch G
No affiliation info available

MeSH

Adrenergic alpha-AntagonistsAdrenergic beta-AntagonistsAdultBlood PressureCardiac OutputEthanolaminesFemaleHeart RateHemodynamicsHumansHypertensionInjections, IntravenousLabetalolMaleMiddle AgedPhysical ExertionTime FactorsVascular Resistance

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

10950

Citation

Koch, G. "Haemodynamic Effects of Combined Alpha- and Beta-adrenoreceptor Blockade After Intravenous Labetalol in Hypertensive Patients at Rest and During Exercise." British Journal of Clinical Pharmacology, vol. 3, no. 4 Suppl 3, 1976, pp. 725-8.
Koch G. Haemodynamic effects of combined alpha- and beta-adrenoreceptor blockade after intravenous labetalol in hypertensive patients at rest and during exercise. Br J Clin Pharmacol. 1976;3(4 Suppl 3):725-8.
Koch, G. (1976). Haemodynamic effects of combined alpha- and beta-adrenoreceptor blockade after intravenous labetalol in hypertensive patients at rest and during exercise. British Journal of Clinical Pharmacology, 3(4 Suppl 3), 725-8.
Koch G. Haemodynamic Effects of Combined Alpha- and Beta-adrenoreceptor Blockade After Intravenous Labetalol in Hypertensive Patients at Rest and During Exercise. Br J Clin Pharmacol. 1976;3(4 Suppl 3):725-8. PubMed PMID: 10950.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Haemodynamic effects of combined alpha- and beta-adrenoreceptor blockade after intravenous labetalol in hypertensive patients at rest and during exercise. A1 - Koch,G, PY - 1976/8/1/pubmed PY - 1976/8/1/medline PY - 1976/8/1/entrez SP - 725 EP - 8 JF - British journal of clinical pharmacology JO - Br J Clin Pharmacol VL - 3 IS - 4 Suppl 3 N2 - 1 The haemodynamic effects of labetalol 50 mg intravenously were studied in 13 hypertensive patients at rest in the supine and upright positions and during exercise using percutaneous right heart and brachial artery catheterization. 2 Labetalol induced immediate significant reductions in systolic and diastolic blood pressures in all conditions. 3 Heart rate, stroke volume and cardiac output were not significantly altered in the supine position at rest but were significantly reduced in the upright position. In addition systemic vascular resistance was significantly reduced. 4 During exercise, heart-rate, cardiac output and vascular resistance were significantly reduced; stroke volume was increased. Left ventriclac filling pressures were unchanged both at rest and during exercise. 5 It was concluded that these changes resulted from blockade to both alpha- and beta-adrenoreceptor. SN - 0306-5251 UR - https://www.unboundmedicine.com/medline/citation/10950/Haemodynamic_effects_of_combined_alpha__and_beta_adrenoreceptor_blockade_after_intravenous_labetalol_in_hypertensive_patients_at_rest_and_during_exercise_ DB - PRIME DP - Unbound Medicine ER -