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The prognostic significance of subclinical hepatic encephalopathy.
Am J Gastroenterol 2000; 95(8):2029-34AJ

Abstract

OBJECTIVE

Subclinical hepatic encephalopathy may have prognostic significance with regard to the development of clinical hepatic encephalopathy and survival.

METHODS

We studied 116 consecutive patients with histologically proven cirrhosis of the liver for subclinical hepatic encephalopathy, using Number Connection Test A, Digit Symbol Test, and spectral analysis of the electroencephalogram.

RESULTS

Twenty-five patients (22%) were diagnosed as having subclinical hepatic encephalopathy. Patients with subclinical hepatic encephalopathy were older, had a higher Child-Pugh score, and more often had esophageal or gastric varices and episode(s) of clinical hepatic encephalopathy in their history. During a median follow-up of 29 months (range, 1-49 months), patients with subclinical hepatic encephalopathy significantly more often had episodes of clinical hepatic encephalopathy; survival, however, was similar to that of patients without subclinical hepatic encephalopathy, and was determined mainly by the Child-Pugh score. The Child-Pugh score was also superior to subclinical hepatic encephalopathy in predicting episodes of clinical hepatic encephalopathy.

CONCLUSIONS

The prognostic significance of subclinical hepatic encephalopathy appears limited.

Authors+Show Affiliations

Department of Hepatogastroenterology, Erasmus University Hospital Rotterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10950053

Citation

Hartmann, I J., et al. "The Prognostic Significance of Subclinical Hepatic Encephalopathy." The American Journal of Gastroenterology, vol. 95, no. 8, 2000, pp. 2029-34.
Hartmann IJ, Groeneweg M, Quero JC, et al. The prognostic significance of subclinical hepatic encephalopathy. Am J Gastroenterol. 2000;95(8):2029-34.
Hartmann, I. J., Groeneweg, M., Quero, J. C., Beijeman, S. J., de Man, R. A., Hop, W. C., & Schalm, S. W. (2000). The prognostic significance of subclinical hepatic encephalopathy. The American Journal of Gastroenterology, 95(8), pp. 2029-34.
Hartmann IJ, et al. The Prognostic Significance of Subclinical Hepatic Encephalopathy. Am J Gastroenterol. 2000;95(8):2029-34. PubMed PMID: 10950053.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The prognostic significance of subclinical hepatic encephalopathy. AU - Hartmann,I J, AU - Groeneweg,M, AU - Quero,J C, AU - Beijeman,S J, AU - de Man,R A, AU - Hop,W C, AU - Schalm,S W, PY - 2000/8/19/pubmed PY - 2000/9/2/medline PY - 2000/8/19/entrez SP - 2029 EP - 34 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 95 IS - 8 N2 - OBJECTIVE: Subclinical hepatic encephalopathy may have prognostic significance with regard to the development of clinical hepatic encephalopathy and survival. METHODS: We studied 116 consecutive patients with histologically proven cirrhosis of the liver for subclinical hepatic encephalopathy, using Number Connection Test A, Digit Symbol Test, and spectral analysis of the electroencephalogram. RESULTS: Twenty-five patients (22%) were diagnosed as having subclinical hepatic encephalopathy. Patients with subclinical hepatic encephalopathy were older, had a higher Child-Pugh score, and more often had esophageal or gastric varices and episode(s) of clinical hepatic encephalopathy in their history. During a median follow-up of 29 months (range, 1-49 months), patients with subclinical hepatic encephalopathy significantly more often had episodes of clinical hepatic encephalopathy; survival, however, was similar to that of patients without subclinical hepatic encephalopathy, and was determined mainly by the Child-Pugh score. The Child-Pugh score was also superior to subclinical hepatic encephalopathy in predicting episodes of clinical hepatic encephalopathy. CONCLUSIONS: The prognostic significance of subclinical hepatic encephalopathy appears limited. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/10950053/The_prognostic_significance_of_subclinical_hepatic_encephalopathy_ L2 - http://Insights.ovid.com/pubmed?pmid=10950053 DB - PRIME DP - Unbound Medicine ER -