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Vitamin D(3) and vitamin K(1) supplementation of Dutch postmenopausal women with normal and low bone mineral densities: effects on serum 25-hydroxyvitamin D and carboxylated osteocalcin.
Eur J Clin Nutr 2000; 54(8):626-31EJ

Abstract

OBJECTIVE

Improvement of vitamin D and K status of about 60 -y-old postmenopausal Dutch women.

DESIGN

In a randomized study postmenopausal women with normal (T-score >-1; n=96) and low (T-score< or =-1; n=45) bone mineral density (BMD) of the lumbar spine, were supplemented with 350-400 IU vitamin D(3), 80 microg vitamins K(1) vitamins K(1)+D(3), or placebo for 1 y. Serum 25-hydroxyvitamin D [25(OH)D] and percentage carboxylated osteocalcin (%carbOC) were measured at baseline and after 3, 6 and 12 months.

RESULTS

Baseline %carbOC of the entire study population was positively correlated with BMD of the lumbar spine and femoral neck. Correspondingly, women with low BMD had lower %carbOC at baseline than women with normal BMD but this difference disappeared after 1 y of supplementation with vitamin K(1) ((mean+/-s.d.) 68+/-11% (95% CI, 64. 5-71.2%) vs 72+/-6% (95% CI, 70.1-72.9%), respectively). One year of supplementation with vitamin D(3) showed maximum increases in 25(OH)D of 33+/-29% (95% CI, 24.8-41.8%) and 68+/-58% (95% CI, 50.1-84.6%) in women with normal and low BMD, respectively. During winter, however, a 29% decline in maximum 25(OH)D levels was not prevented in women with low BMD.

CONCLUSION

Daily supplementation of Dutch postmenopausal women with >400 IU vitamin D(3) is indicated to prevent a winter decline in 25(OH)D and to control serum parathyroid hormone levels. Daily supplementation with 80 microg vitamin K(1) seems to be necessary to reach premenopausal %carbOC levels. A stimulatory effect of calcium and/or vitamin D on %carbOC cannot be excluded. European Journal of Clinical Nutrition (2000) 54, 626-631.

Authors+Show Affiliations

Department of Research & Development Leeuwarden, Friesland Coberco Dairy Foods, Leeuwarden, The Netherlands. SchaafsA@FDF.NLNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

10951511

Citation

Schaafsma, A, et al. "Vitamin D(3) and Vitamin K(1) Supplementation of Dutch Postmenopausal Women With Normal and Low Bone Mineral Densities: Effects On Serum 25-hydroxyvitamin D and Carboxylated Osteocalcin." European Journal of Clinical Nutrition, vol. 54, no. 8, 2000, pp. 626-31.
Schaafsma A, Muskiet FA, Storm H, et al. Vitamin D(3) and vitamin K(1) supplementation of Dutch postmenopausal women with normal and low bone mineral densities: effects on serum 25-hydroxyvitamin D and carboxylated osteocalcin. Eur J Clin Nutr. 2000;54(8):626-31.
Schaafsma, A., Muskiet, F. A., Storm, H., Hofstede, G. J., Pakan, I., & Van der Veer, E. (2000). Vitamin D(3) and vitamin K(1) supplementation of Dutch postmenopausal women with normal and low bone mineral densities: effects on serum 25-hydroxyvitamin D and carboxylated osteocalcin. European Journal of Clinical Nutrition, 54(8), pp. 626-31.
Schaafsma A, et al. Vitamin D(3) and Vitamin K(1) Supplementation of Dutch Postmenopausal Women With Normal and Low Bone Mineral Densities: Effects On Serum 25-hydroxyvitamin D and Carboxylated Osteocalcin. Eur J Clin Nutr. 2000;54(8):626-31. PubMed PMID: 10951511.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D(3) and vitamin K(1) supplementation of Dutch postmenopausal women with normal and low bone mineral densities: effects on serum 25-hydroxyvitamin D and carboxylated osteocalcin. AU - Schaafsma,A, AU - Muskiet,F A, AU - Storm,H, AU - Hofstede,G J, AU - Pakan,I, AU - Van der Veer,E, PY - 2000/8/22/pubmed PY - 2001/2/28/medline PY - 2000/8/22/entrez SP - 626 EP - 31 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 54 IS - 8 N2 - OBJECTIVE: Improvement of vitamin D and K status of about 60 -y-old postmenopausal Dutch women. DESIGN: In a randomized study postmenopausal women with normal (T-score >-1; n=96) and low (T-score< or =-1; n=45) bone mineral density (BMD) of the lumbar spine, were supplemented with 350-400 IU vitamin D(3), 80 microg vitamins K(1) vitamins K(1)+D(3), or placebo for 1 y. Serum 25-hydroxyvitamin D [25(OH)D] and percentage carboxylated osteocalcin (%carbOC) were measured at baseline and after 3, 6 and 12 months. RESULTS: Baseline %carbOC of the entire study population was positively correlated with BMD of the lumbar spine and femoral neck. Correspondingly, women with low BMD had lower %carbOC at baseline than women with normal BMD but this difference disappeared after 1 y of supplementation with vitamin K(1) ((mean+/-s.d.) 68+/-11% (95% CI, 64. 5-71.2%) vs 72+/-6% (95% CI, 70.1-72.9%), respectively). One year of supplementation with vitamin D(3) showed maximum increases in 25(OH)D of 33+/-29% (95% CI, 24.8-41.8%) and 68+/-58% (95% CI, 50.1-84.6%) in women with normal and low BMD, respectively. During winter, however, a 29% decline in maximum 25(OH)D levels was not prevented in women with low BMD. CONCLUSION: Daily supplementation of Dutch postmenopausal women with >400 IU vitamin D(3) is indicated to prevent a winter decline in 25(OH)D and to control serum parathyroid hormone levels. Daily supplementation with 80 microg vitamin K(1) seems to be necessary to reach premenopausal %carbOC levels. A stimulatory effect of calcium and/or vitamin D on %carbOC cannot be excluded. European Journal of Clinical Nutrition (2000) 54, 626-631. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/10951511/Vitamin_D_3__and_vitamin_K_1__supplementation_of_Dutch_postmenopausal_women_with_normal_and_low_bone_mineral_densities:_effects_on_serum_25_hydroxyvitamin_D_and_carboxylated_osteocalcin_ L2 - https://medlineplus.gov/bonedensity.html DB - PRIME DP - Unbound Medicine ER -