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Vegetables, fruits, legumes and prostate cancer: a multiethnic case-control study.

Abstract

The evidence for a protective effect of vegetables, fruits, and legumes against prostate cancer is weak and inconsistent. We examined the relationship of these food groups and their constituent foods to prostate cancer risk in a multicenter case-control study of African-American, white, Japanese, and Chinese men. Cases (n = 1619) with histologically confirmed prostate cancer were identified through the population-based tumor registries of Hawaii, San Francisco, and Los Angeles in the United States and British Columbia and Ontario in Canada. Controls (n = 1618) were frequency-matched to cases on ethnicity, age, and region of residence of the case, in a ratio of approximately 1:1. Dietary and other information was collected by in-person home interview; a blood sample was obtained from control subjects for prostate-specific antigen determination. Odds ratios (OR) were estimated using logistic regression, adjusting for age, geographic location, education, calories, and when indicated, ethnicity. Intake of legumes (whether total legumes, soyfoods specifically, or other legumes) was inversely related to prostate cancer (OR for highest relative to lowest quintile for total legumes = 0.62; P for trend = 0.0002); results were similar when restricted to prostate-specific antigen-normal controls or to advanced cases. Intakes of yellow-orange and cruciferous vegetables were also inversely related to prostate cancer, especially for advanced cases, among whom the highest quintile OR for yellow-orange vegetables = 0.67 (P for trend = 0.01) and the highest quintile OR for cruciferous vegetables = 0.61 (P for trend = 0.006). Intake of tomatoes and of fruits was not related to risk. Findings were generally consistent across ethnic groups. These results suggest that legumes (not limited to soy products) and certain categories of vegetables may protect against prostate cancer.

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  • Authors+Show Affiliations

    ,

    Cancer Research Center, University of Hawaii, Honolulu 96813, USA.

    , , , , , , , , ,

    Source

    MeSH

    African Continental Ancestry Group
    Aged
    Anticarcinogenic Agents
    Asian Continental Ancestry Group
    British Columbia
    California
    Case-Control Studies
    Diet Surveys
    European Continental Ancestry Group
    Fabaceae
    Feeding Behavior
    Fruit
    Hawaii
    Humans
    Logistic Models
    Male
    Odds Ratio
    Ontario
    Phytotherapy
    Plants, Medicinal
    Prostate-Specific Antigen
    Prostatic Neoplasms
    Vegetables

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    10952096

    Citation

    Kolonel, L N., et al. "Vegetables, Fruits, Legumes and Prostate Cancer: a Multiethnic Case-control Study." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 9, no. 8, 2000, pp. 795-804.
    Kolonel LN, Hankin JH, Whittemore AS, et al. Vegetables, fruits, legumes and prostate cancer: a multiethnic case-control study. Cancer Epidemiol Biomarkers Prev. 2000;9(8):795-804.
    Kolonel, L. N., Hankin, J. H., Whittemore, A. S., Wu, A. H., Gallagher, R. P., Wilkens, L. R., ... Paffenbarger, R. S. (2000). Vegetables, fruits, legumes and prostate cancer: a multiethnic case-control study. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 9(8), pp. 795-804.
    Kolonel LN, et al. Vegetables, Fruits, Legumes and Prostate Cancer: a Multiethnic Case-control Study. Cancer Epidemiol Biomarkers Prev. 2000;9(8):795-804. PubMed PMID: 10952096.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vegetables, fruits, legumes and prostate cancer: a multiethnic case-control study. AU - Kolonel,L N, AU - Hankin,J H, AU - Whittemore,A S, AU - Wu,A H, AU - Gallagher,R P, AU - Wilkens,L R, AU - John,E M, AU - Howe,G R, AU - Dreon,D M, AU - West,D W, AU - Paffenbarger,R S,Jr PY - 2000/8/22/pubmed PY - 2001/2/28/medline PY - 2000/8/22/entrez SP - 795 EP - 804 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 9 IS - 8 N2 - The evidence for a protective effect of vegetables, fruits, and legumes against prostate cancer is weak and inconsistent. We examined the relationship of these food groups and their constituent foods to prostate cancer risk in a multicenter case-control study of African-American, white, Japanese, and Chinese men. Cases (n = 1619) with histologically confirmed prostate cancer were identified through the population-based tumor registries of Hawaii, San Francisco, and Los Angeles in the United States and British Columbia and Ontario in Canada. Controls (n = 1618) were frequency-matched to cases on ethnicity, age, and region of residence of the case, in a ratio of approximately 1:1. Dietary and other information was collected by in-person home interview; a blood sample was obtained from control subjects for prostate-specific antigen determination. Odds ratios (OR) were estimated using logistic regression, adjusting for age, geographic location, education, calories, and when indicated, ethnicity. Intake of legumes (whether total legumes, soyfoods specifically, or other legumes) was inversely related to prostate cancer (OR for highest relative to lowest quintile for total legumes = 0.62; P for trend = 0.0002); results were similar when restricted to prostate-specific antigen-normal controls or to advanced cases. Intakes of yellow-orange and cruciferous vegetables were also inversely related to prostate cancer, especially for advanced cases, among whom the highest quintile OR for yellow-orange vegetables = 0.67 (P for trend = 0.01) and the highest quintile OR for cruciferous vegetables = 0.61 (P for trend = 0.006). Intake of tomatoes and of fruits was not related to risk. Findings were generally consistent across ethnic groups. These results suggest that legumes (not limited to soy products) and certain categories of vegetables may protect against prostate cancer. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/10952096/full_citation L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=10952096 DB - PRIME DP - Unbound Medicine ER -