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Intravenous labetalol in hypertensive patients treated with beta-adrenoreceptor-blocking drugs.
Br J Clin Pharmacol. 1976 Aug; 3(4 Suppl 3):795-8.BJ

Abstract

1 The effect of intravenous injections of labetalol at doses of 1 and 2 mg/kg was studied in 15 patients with severe hypertension inadequately controlled by beta-adrenoreceptor-blocking drugs. 2 At a dose of 1 mg/kg there was a slight but statistically insignificant reduction in blood pressure. When 2 mg/kg was given there was a prolonged (6 h) significant reduction in lying blood pressure. At both dose levels there was a small initial increase in pulse rate but forced peak flow was not affected. 3 Side-effects were limited to transient postural hypotension and a feeling of warmth. 4 It is concluded that intravenous labetalol at a dose of 2 mg/kg is safe and effective in rapidly reducing blood pressure in patients already receiving beta-adrenoreceptor-blocking drugs.

Authors

Pearson RM
No affiliation info available
Havard CW
No affiliation info available

MeSH

Adrenergic beta-AntagonistsAdultBlood PressureDose-Response Relationship, DrugDrug ResistanceEthanolaminesFemaleHumansHypertensionInjections, IntravenousLabetalolMaleMiddle AgedPeak Expiratory Flow RatePulse

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

10953

Citation

Pearson, R M., and C W. Havard. "Intravenous Labetalol in Hypertensive Patients Treated With Beta-adrenoreceptor-blocking Drugs." British Journal of Clinical Pharmacology, vol. 3, no. 4 Suppl 3, 1976, pp. 795-8.
Pearson RM, Havard CW. Intravenous labetalol in hypertensive patients treated with beta-adrenoreceptor-blocking drugs. Br J Clin Pharmacol. 1976;3(4 Suppl 3):795-8.
Pearson, R. M., & Havard, C. W. (1976). Intravenous labetalol in hypertensive patients treated with beta-adrenoreceptor-blocking drugs. British Journal of Clinical Pharmacology, 3(4 Suppl 3), 795-8.
Pearson RM, Havard CW. Intravenous Labetalol in Hypertensive Patients Treated With Beta-adrenoreceptor-blocking Drugs. Br J Clin Pharmacol. 1976;3(4 Suppl 3):795-8. PubMed PMID: 10953.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intravenous labetalol in hypertensive patients treated with beta-adrenoreceptor-blocking drugs. AU - Pearson,R M, AU - Havard,C W, PY - 1976/8/1/pubmed PY - 1976/8/1/medline PY - 1976/8/1/entrez SP - 795 EP - 8 JF - British journal of clinical pharmacology JO - Br J Clin Pharmacol VL - 3 IS - 4 Suppl 3 N2 - 1 The effect of intravenous injections of labetalol at doses of 1 and 2 mg/kg was studied in 15 patients with severe hypertension inadequately controlled by beta-adrenoreceptor-blocking drugs. 2 At a dose of 1 mg/kg there was a slight but statistically insignificant reduction in blood pressure. When 2 mg/kg was given there was a prolonged (6 h) significant reduction in lying blood pressure. At both dose levels there was a small initial increase in pulse rate but forced peak flow was not affected. 3 Side-effects were limited to transient postural hypotension and a feeling of warmth. 4 It is concluded that intravenous labetalol at a dose of 2 mg/kg is safe and effective in rapidly reducing blood pressure in patients already receiving beta-adrenoreceptor-blocking drugs. SN - 0306-5251 UR - https://www.unboundmedicine.com/medline/citation/10953/Intravenous_labetalol_in_hypertensive_patients_treated_with_beta_adrenoreceptor_blocking_drugs_ DB - PRIME DP - Unbound Medicine ER -