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Postprandial factor VII metabolism: the effect of the R353Q and 10 bp polymorphisms.
Br J Nutr. 2000 May; 83(5):467-72.BJ

Abstract

Elevated levels of coagulation factor VII activity (FVIIc) are associated with increased risk of CHD. FVIIc is strongly determined by two polymorphisms (R353Q and 0/10 base pairs (bp)) and plasma triacylglycerol (TAG) concentrations. The Q and 10 bp polymorphisms show strong linkage disequilibrium and have been associated with lower levels of fasting FVII, but there has been little investigation of the effect of these genotypes on the postprandial FVII metabolism. The present study demonstrated that fasting activated factor VII (FVIIa) and factor VII antigen (FVIIag) levels were significantly lower in the heterozygotes carrying the Q and 10 bp alleles (n 12), than in the R/0 bp homozygotes (n 12) (43.0 (SE 4.8) v. 23.9 (SE 6.5) mU/ml and 85.7 (SE 5.4) v. 71.6 (SE 7.5)% respectively). During postprandial lipaemia there was a significant increase in FVIIa in R/0 bp homozygotes but not in the heterozygotes carrying the Q and 10 bp alleles. The proportion of FVIIa (FVIIa:FVIIag) increased in the homozygotes but not in the heterozygotes (2.04 (SE 0.35) v. 1.20 (SE 0.26) respectively). Therefore possession of the relatively common Q and 10 bp alleles is not associated with postprandial activation of FVII, which may in turn have a protective effect against CHD.

Authors+Show Affiliations

Department of Clinical Medicine, Trinity Centre for Health Sciences, St. James's Hospital, Dublin, Republic of Ireland. hmroche@tcd.ieNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10953670

Citation

Roche, H M., et al. "Postprandial Factor VII Metabolism: the Effect of the R353Q and 10 Bp Polymorphisms." The British Journal of Nutrition, vol. 83, no. 5, 2000, pp. 467-72.
Roche HM, Black IL, Noone E, et al. Postprandial factor VII metabolism: the effect of the R353Q and 10 bp polymorphisms. Br J Nutr. 2000;83(5):467-72.
Roche, H. M., Black, I. L., Noone, E., Tully, A. M., Whitehead, A. S., & Gibney, M. J. (2000). Postprandial factor VII metabolism: the effect of the R353Q and 10 bp polymorphisms. The British Journal of Nutrition, 83(5), 467-72.
Roche HM, et al. Postprandial Factor VII Metabolism: the Effect of the R353Q and 10 Bp Polymorphisms. Br J Nutr. 2000;83(5):467-72. PubMed PMID: 10953670.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postprandial factor VII metabolism: the effect of the R353Q and 10 bp polymorphisms. AU - Roche,H M, AU - Black,I L, AU - Noone,E, AU - Tully,A M, AU - Whitehead,A S, AU - Gibney,M J, PY - 2000/8/23/pubmed PY - 2000/8/29/medline PY - 2000/8/23/entrez SP - 467 EP - 72 JF - The British journal of nutrition JO - Br J Nutr VL - 83 IS - 5 N2 - Elevated levels of coagulation factor VII activity (FVIIc) are associated with increased risk of CHD. FVIIc is strongly determined by two polymorphisms (R353Q and 0/10 base pairs (bp)) and plasma triacylglycerol (TAG) concentrations. The Q and 10 bp polymorphisms show strong linkage disequilibrium and have been associated with lower levels of fasting FVII, but there has been little investigation of the effect of these genotypes on the postprandial FVII metabolism. The present study demonstrated that fasting activated factor VII (FVIIa) and factor VII antigen (FVIIag) levels were significantly lower in the heterozygotes carrying the Q and 10 bp alleles (n 12), than in the R/0 bp homozygotes (n 12) (43.0 (SE 4.8) v. 23.9 (SE 6.5) mU/ml and 85.7 (SE 5.4) v. 71.6 (SE 7.5)% respectively). During postprandial lipaemia there was a significant increase in FVIIa in R/0 bp homozygotes but not in the heterozygotes carrying the Q and 10 bp alleles. The proportion of FVIIa (FVIIa:FVIIag) increased in the homozygotes but not in the heterozygotes (2.04 (SE 0.35) v. 1.20 (SE 0.26) respectively). Therefore possession of the relatively common Q and 10 bp alleles is not associated with postprandial activation of FVII, which may in turn have a protective effect against CHD. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/10953670/Postprandial_factor_VII_metabolism:_the_effect_of_the_R353Q_and_10_bp_polymorphisms_ L2 - https://www.cambridge.org/core/product/identifier/S0007114500000593/type/journal_article DB - PRIME DP - Unbound Medicine ER -