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Brainstem-type Lewy body disease presenting with progressive autonomic failure and lethargy.
Clin Auton Res. 2000 Jun; 10(3):139-43.CA

Abstract

The authors report an autopsy case characterized by progressive lethargy and autonomic failure with a distinctive pattern of occurrence of Lewy bodies. Autonomic dysfunction such as sleep apnea, orthostatic hypotension, dysuria, and hypohidrosis predominated with lethargy, whereas parkinsonism was not apparent. Numerous Lewy bodies were widely evident microscopically in brainstem nuclei and the intermediolateral cell columns of the spinal cord, as well as in the sympathetic ganglia, but were rare or absent in the cerebral cortex and other supratentorial structures. Marked neuronal loss was seen in the locus ceruleus, raphe nuclei, dorsal vagal nuclei, and intermediolateral cell columns, but neurons in the substantia nigra, other brain regions, and sympathetic ganglia appeared undiminished. This case represents a specific clinicopathologic form of Lewy body disease occurring predominantly in the brainstem, spinal cord, and sympathetic ganglia.

Authors+Show Affiliations

Department of Neurology, Nagoya University School of Medicine, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10954072

Citation

Hishikawa, N, et al. "Brainstem-type Lewy Body Disease Presenting With Progressive Autonomic Failure and Lethargy." Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society, vol. 10, no. 3, 2000, pp. 139-43.
Hishikawa N, Hashizume Y, Hirayama M, et al. Brainstem-type Lewy body disease presenting with progressive autonomic failure and lethargy. Clin Auton Res. 2000;10(3):139-43.
Hishikawa, N., Hashizume, Y., Hirayama, M., Imamura, K., Washimi, Y., Koike, Y., Mabuchi, C., Yoshida, M., & Sobue, G. (2000). Brainstem-type Lewy body disease presenting with progressive autonomic failure and lethargy. Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society, 10(3), 139-43.
Hishikawa N, et al. Brainstem-type Lewy Body Disease Presenting With Progressive Autonomic Failure and Lethargy. Clin Auton Res. 2000;10(3):139-43. PubMed PMID: 10954072.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Brainstem-type Lewy body disease presenting with progressive autonomic failure and lethargy. AU - Hishikawa,N, AU - Hashizume,Y, AU - Hirayama,M, AU - Imamura,K, AU - Washimi,Y, AU - Koike,Y, AU - Mabuchi,C, AU - Yoshida,M, AU - Sobue,G, PY - 2000/8/23/pubmed PY - 2001/2/28/medline PY - 2000/8/23/entrez SP - 139 EP - 43 JF - Clinical autonomic research : official journal of the Clinical Autonomic Research Society JO - Clin Auton Res VL - 10 IS - 3 N2 - The authors report an autopsy case characterized by progressive lethargy and autonomic failure with a distinctive pattern of occurrence of Lewy bodies. Autonomic dysfunction such as sleep apnea, orthostatic hypotension, dysuria, and hypohidrosis predominated with lethargy, whereas parkinsonism was not apparent. Numerous Lewy bodies were widely evident microscopically in brainstem nuclei and the intermediolateral cell columns of the spinal cord, as well as in the sympathetic ganglia, but were rare or absent in the cerebral cortex and other supratentorial structures. Marked neuronal loss was seen in the locus ceruleus, raphe nuclei, dorsal vagal nuclei, and intermediolateral cell columns, but neurons in the substantia nigra, other brain regions, and sympathetic ganglia appeared undiminished. This case represents a specific clinicopathologic form of Lewy body disease occurring predominantly in the brainstem, spinal cord, and sympathetic ganglia. SN - 0959-9851 UR - https://www.unboundmedicine.com/medline/citation/10954072/Brainstem_type_Lewy_body_disease_presenting_with_progressive_autonomic_failure_and_lethargy_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=10954072.ui DB - PRIME DP - Unbound Medicine ER -