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Immune response to influenza vaccine in healthy elderly: lack of association with plasma beta-carotene, retinol, alpha-tocopherol, or zinc.

Abstract

Immunity and nutritional status are compromised with age, yet the relationship between them is unclear. Immune responses and plasma micronutrient levels of 61 healthy elderly (mean 81 years) and 27 young (mean 27 years) were assessed before and after immunization with trivalent influenza vaccine (FLU). FLU-induced proliferation and IFN-gamma levels of elderly were lower than young before and after immunization. Proliferation and IFN-gamma levels increased after immunization of young, but not elderly. FLU-induced IL-6 and IL-10 levels did not change after immunization of either group. While antibody titers to all three FLU components increased after vaccination of young and elderly, post-vaccination titers of elderly were lower than young. Although plasma retinol and zinc levels of young and elderly were similar before and after vaccination, elderly had higher plasma beta-carotene and alpha-tocopherol levels at both assessments that increased after vaccination. Importantly, plasma micronutrient levels were comparable for elderly with or without intact (titers >/=40 and fourfold rise post-vaccination) antibody responses after vaccination. These results suggest that differences in these plasma micronutrients (1) are not required to observe decreased FLU responses of healthy elderly compared to young and (2) are not associated with differences in antibody responses among healthy elderly.

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  • Authors+Show Affiliations

    ,

    Department of Microbiology and Immunology, MCP Hahnemann University, 2900 Queen Lane, Philadelphia, PA 19129, USA.

    , , , ,

    Source

    Mechanisms of ageing and development 117:1-3 2000 Aug 15 pg 29-45

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Aging
    Antibodies, Viral
    Cell Division
    Female
    Health Status
    Humans
    Influenza A virus
    Influenza B virus
    Influenza Vaccines
    Influenza, Human
    Leukocytes, Mononuclear
    Male
    Vitamin A
    Vitamin E
    Zinc
    beta Carotene

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    10958921

    Citation

    Gardner, E M., et al. "Immune Response to Influenza Vaccine in Healthy Elderly: Lack of Association With Plasma Beta-carotene, Retinol, Alpha-tocopherol, or Zinc." Mechanisms of Ageing and Development, vol. 117, no. 1-3, 2000, pp. 29-45.
    Gardner EM, Bernstein ED, Popoff KA, et al. Immune response to influenza vaccine in healthy elderly: lack of association with plasma beta-carotene, retinol, alpha-tocopherol, or zinc. Mech Ageing Dev. 2000;117(1-3):29-45.
    Gardner, E. M., Bernstein, E. D., Popoff, K. A., Abrutyn, E., Gross, P., & Murasko, D. M. (2000). Immune response to influenza vaccine in healthy elderly: lack of association with plasma beta-carotene, retinol, alpha-tocopherol, or zinc. Mechanisms of Ageing and Development, 117(1-3), pp. 29-45.
    Gardner EM, et al. Immune Response to Influenza Vaccine in Healthy Elderly: Lack of Association With Plasma Beta-carotene, Retinol, Alpha-tocopherol, or Zinc. Mech Ageing Dev. 2000 Aug 15;117(1-3):29-45. PubMed PMID: 10958921.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Immune response to influenza vaccine in healthy elderly: lack of association with plasma beta-carotene, retinol, alpha-tocopherol, or zinc. AU - Gardner,E M, AU - Bernstein,E D, AU - Popoff,K A, AU - Abrutyn,E, AU - Gross,P, AU - Murasko,D M, PY - 2000/8/26/pubmed PY - 2001/2/28/medline PY - 2000/8/26/entrez SP - 29 EP - 45 JF - Mechanisms of ageing and development JO - Mech. Ageing Dev. VL - 117 IS - 1-3 N2 - Immunity and nutritional status are compromised with age, yet the relationship between them is unclear. Immune responses and plasma micronutrient levels of 61 healthy elderly (mean 81 years) and 27 young (mean 27 years) were assessed before and after immunization with trivalent influenza vaccine (FLU). FLU-induced proliferation and IFN-gamma levels of elderly were lower than young before and after immunization. Proliferation and IFN-gamma levels increased after immunization of young, but not elderly. FLU-induced IL-6 and IL-10 levels did not change after immunization of either group. While antibody titers to all three FLU components increased after vaccination of young and elderly, post-vaccination titers of elderly were lower than young. Although plasma retinol and zinc levels of young and elderly were similar before and after vaccination, elderly had higher plasma beta-carotene and alpha-tocopherol levels at both assessments that increased after vaccination. Importantly, plasma micronutrient levels were comparable for elderly with or without intact (titers >/=40 and fourfold rise post-vaccination) antibody responses after vaccination. These results suggest that differences in these plasma micronutrients (1) are not required to observe decreased FLU responses of healthy elderly compared to young and (2) are not associated with differences in antibody responses among healthy elderly. SN - 0047-6374 UR - https://www.unboundmedicine.com/medline/citation/10958921/Immune_response_to_influenza_vaccine_in_healthy_elderly:_lack_of_association_with_plasma_beta_carotene_retinol_alpha_tocopherol_or_zinc_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0047-6374(00)00134-2 DB - PRIME DP - Unbound Medicine ER -