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Lower levels of PAI-2 may contribute to impaired healing in venous ulcers - a preliminary study.
Cardiovasc Surg. 2000 Aug; 8(5):381-5.CS

Abstract

Plasminogen activators may potentially influence the wound healing processes of cell migration, matrix degradation and cellular adhesion in venous ulcers by their regulation of protease activity. The aim of this study was to assess the levels of plasminogen activators in venous ulcers and to gain preliminary data from healing wounds. The concentrations of u-PA, t-PA, PAI-1 and PAI-2 antigen as well as functional u-PA were assessed in tissue homogenates from 20 chronic venous ulcers, six actively healing venous ulcers and five traumatic wounds. The concentrations of functional u-PA, u-PA antigen and PAI-1 were significantly greater and PAI-2 was significantly lower in the edge and base of chronic venous ulcers compared to adjacent intact skin (P<0.01). Healing wounds had significantly higher functional u-PA at the ulcer edge and higher u-PA antigen concentration in intact skin (P<0.05). PAI-2 levels were significantly higher in the ulcer edge and base in the healing wounds than in chronic venous ulcers (P<0.05). These findings suggest that regulation of protease activity by u-PA and PAI-2 may play a role in the impaired healing of chronic venous ulcers.

Authors+Show Affiliations

Department of Surgery, University of Western Australia, Fremantle Hospital, PO Box 480, Fremantle, Australia. mstacey@cyllene.uwa.edu.auNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10959063

Citation

Stacey, M C., and S D. Mata. "Lower Levels of PAI-2 May Contribute to Impaired Healing in Venous Ulcers - a Preliminary Study." Cardiovascular Surgery (London, England), vol. 8, no. 5, 2000, pp. 381-5.
Stacey MC, Mata SD. Lower levels of PAI-2 may contribute to impaired healing in venous ulcers - a preliminary study. Cardiovasc Surg. 2000;8(5):381-5.
Stacey, M. C., & Mata, S. D. (2000). Lower levels of PAI-2 may contribute to impaired healing in venous ulcers - a preliminary study. Cardiovascular Surgery (London, England), 8(5), 381-5.
Stacey MC, Mata SD. Lower Levels of PAI-2 May Contribute to Impaired Healing in Venous Ulcers - a Preliminary Study. Cardiovasc Surg. 2000;8(5):381-5. PubMed PMID: 10959063.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lower levels of PAI-2 may contribute to impaired healing in venous ulcers - a preliminary study. AU - Stacey,M C, AU - Mata,S D, PY - 2000/8/26/pubmed PY - 2001/2/28/medline PY - 2000/8/26/entrez SP - 381 EP - 5 JF - Cardiovascular surgery (London, England) JO - Cardiovasc Surg VL - 8 IS - 5 N2 - Plasminogen activators may potentially influence the wound healing processes of cell migration, matrix degradation and cellular adhesion in venous ulcers by their regulation of protease activity. The aim of this study was to assess the levels of plasminogen activators in venous ulcers and to gain preliminary data from healing wounds. The concentrations of u-PA, t-PA, PAI-1 and PAI-2 antigen as well as functional u-PA were assessed in tissue homogenates from 20 chronic venous ulcers, six actively healing venous ulcers and five traumatic wounds. The concentrations of functional u-PA, u-PA antigen and PAI-1 were significantly greater and PAI-2 was significantly lower in the edge and base of chronic venous ulcers compared to adjacent intact skin (P<0.01). Healing wounds had significantly higher functional u-PA at the ulcer edge and higher u-PA antigen concentration in intact skin (P<0.05). PAI-2 levels were significantly higher in the ulcer edge and base in the healing wounds than in chronic venous ulcers (P<0.05). These findings suggest that regulation of protease activity by u-PA and PAI-2 may play a role in the impaired healing of chronic venous ulcers. SN - 0967-2109 UR - https://www.unboundmedicine.com/medline/citation/10959063/Lower_levels_of_PAI_2_may_contribute_to_impaired_healing_in_venous_ulcers___a_preliminary_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0967210900000284 DB - PRIME DP - Unbound Medicine ER -