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Peripheral neuropathy in chronic respiratory insufficiency.
J Peripher Nerv Syst. 1998; 3(1):69-74.JP

Abstract

Peripheral neuropathy commonly occurs in patients with chronic obstructive lung disease (COPD). We report the presence of peripheral neuropathy in 19 of our 30 COPD patients (63.3%): 7 patients had clinical signs of a symmetric motor and sensory polyneuropathy, 12 patients had only subclinical evidence of peripheral nervous system involvement. Neurophysiological studies showed low amplitude compound muscle action potentials (CMAP) and sensory action potentials (SAP) with only slight reduction of nerve conduction velocity in affected patients: these data confirm an axonal polyneuropathy. The severity of the peripheral nervous system involvement in COPD patients was correlated with hypercapnia, the degree of disability and thus with the severity of COPD. Hypoxia, age and duration of the disease were not related with the presence of polyneuropathy. Improvement of respiratory function produced slight but progressive improvement of neurological symptoms. Within one year, also neurophysiological studies revealed a progressive and statistically significant improvement in CMAP and SAP amplitude and motor and sensory conduction velocity and, in some cases, normal electromyography.

Authors+Show Affiliations

Department of Neurology, Niguarda Ca' Granda Hospital, Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10959240

Citation

Jann, S, et al. "Peripheral Neuropathy in Chronic Respiratory Insufficiency." Journal of the Peripheral Nervous System : JPNS, vol. 3, no. 1, 1998, pp. 69-74.
Jann S, Gatti A, Crespi S, et al. Peripheral neuropathy in chronic respiratory insufficiency. J Peripher Nerv Syst. 1998;3(1):69-74.
Jann, S., Gatti, A., Crespi, S., Rolo, J., & Beretta, S. (1998). Peripheral neuropathy in chronic respiratory insufficiency. Journal of the Peripheral Nervous System : JPNS, 3(1), 69-74.
Jann S, et al. Peripheral Neuropathy in Chronic Respiratory Insufficiency. J Peripher Nerv Syst. 1998;3(1):69-74. PubMed PMID: 10959240.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Peripheral neuropathy in chronic respiratory insufficiency. AU - Jann,S, AU - Gatti,A, AU - Crespi,S, AU - Rolo,J, AU - Beretta,S, PY - 2000/8/26/pubmed PY - 2000/9/19/medline PY - 2000/8/26/entrez SP - 69 EP - 74 JF - Journal of the peripheral nervous system : JPNS JO - J Peripher Nerv Syst VL - 3 IS - 1 N2 - Peripheral neuropathy commonly occurs in patients with chronic obstructive lung disease (COPD). We report the presence of peripheral neuropathy in 19 of our 30 COPD patients (63.3%): 7 patients had clinical signs of a symmetric motor and sensory polyneuropathy, 12 patients had only subclinical evidence of peripheral nervous system involvement. Neurophysiological studies showed low amplitude compound muscle action potentials (CMAP) and sensory action potentials (SAP) with only slight reduction of nerve conduction velocity in affected patients: these data confirm an axonal polyneuropathy. The severity of the peripheral nervous system involvement in COPD patients was correlated with hypercapnia, the degree of disability and thus with the severity of COPD. Hypoxia, age and duration of the disease were not related with the presence of polyneuropathy. Improvement of respiratory function produced slight but progressive improvement of neurological symptoms. Within one year, also neurophysiological studies revealed a progressive and statistically significant improvement in CMAP and SAP amplitude and motor and sensory conduction velocity and, in some cases, normal electromyography. SN - 1085-9489 UR - https://www.unboundmedicine.com/medline/citation/10959240/Peripheral_neuropathy_in_chronic_respiratory_insufficiency_ L2 - https://medlineplus.gov/peripheralnervedisorders.html DB - PRIME DP - Unbound Medicine ER -