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Posttraining lesions of the amygdala interfere with fear-potentiated startle to both visual and auditory conditioned stimuli in C57BL/6J mice.
Behav Neurosci. 2000 Aug; 114(4):749-59.BN

Abstract

The fear-potentiated startle paradigm has been used with great success to examine conditioned fear in both rats and humans. The purpose of the present experiment was to extend the authors' previous findings and further validate the fear-potentiated startle paradigm in mice. In Experiments 1 and 2, C57BL/6J mice were given Pavlovian fear conditioning with either an auditory or a visual conditioned stimulus. Similar to data collected with rats, fear-potentiated startle was observed for both stimulus modalities. In Experiment 3, posttraining lesions of the amygdala disrupted fear-potentiated startle in both conditioned stimulus modalities. These data are consistent with amygdala lesion studies in rats and suggest that fear-potentiated startle in mice requires an intact amygdala. Together, these results extend the authors' previous results and provide the basis for using this well-understood behavioral paradigm for examining the molecular mechanisms of conditioned fear in transgenic and knockout mice.

Authors+Show Affiliations

Department of Psychology, Northern Illinois University, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10959534

Citation

Heldt, S, et al. "Posttraining Lesions of the Amygdala Interfere With Fear-potentiated Startle to Both Visual and Auditory Conditioned Stimuli in C57BL/6J Mice." Behavioral Neuroscience, vol. 114, no. 4, 2000, pp. 749-59.
Heldt S, Sundin V, Willott JF, et al. Posttraining lesions of the amygdala interfere with fear-potentiated startle to both visual and auditory conditioned stimuli in C57BL/6J mice. Behav Neurosci. 2000;114(4):749-59.
Heldt, S., Sundin, V., Willott, J. F., & Falls, W. A. (2000). Posttraining lesions of the amygdala interfere with fear-potentiated startle to both visual and auditory conditioned stimuli in C57BL/6J mice. Behavioral Neuroscience, 114(4), 749-59.
Heldt S, et al. Posttraining Lesions of the Amygdala Interfere With Fear-potentiated Startle to Both Visual and Auditory Conditioned Stimuli in C57BL/6J Mice. Behav Neurosci. 2000;114(4):749-59. PubMed PMID: 10959534.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Posttraining lesions of the amygdala interfere with fear-potentiated startle to both visual and auditory conditioned stimuli in C57BL/6J mice. AU - Heldt,S, AU - Sundin,V, AU - Willott,J F, AU - Falls,W A, PY - 2000/8/26/pubmed PY - 2001/2/28/medline PY - 2000/8/26/entrez SP - 749 EP - 59 JF - Behavioral neuroscience JO - Behav Neurosci VL - 114 IS - 4 N2 - The fear-potentiated startle paradigm has been used with great success to examine conditioned fear in both rats and humans. The purpose of the present experiment was to extend the authors' previous findings and further validate the fear-potentiated startle paradigm in mice. In Experiments 1 and 2, C57BL/6J mice were given Pavlovian fear conditioning with either an auditory or a visual conditioned stimulus. Similar to data collected with rats, fear-potentiated startle was observed for both stimulus modalities. In Experiment 3, posttraining lesions of the amygdala disrupted fear-potentiated startle in both conditioned stimulus modalities. These data are consistent with amygdala lesion studies in rats and suggest that fear-potentiated startle in mice requires an intact amygdala. Together, these results extend the authors' previous results and provide the basis for using this well-understood behavioral paradigm for examining the molecular mechanisms of conditioned fear in transgenic and knockout mice. SN - 0735-7044 UR - https://www.unboundmedicine.com/medline/citation/10959534/Posttraining_lesions_of_the_amygdala_interfere_with_fear_potentiated_startle_to_both_visual_and_auditory_conditioned_stimuli_in_C57BL/6J_mice_ L2 - http://content.apa.org/journals/bne/114/4/749 DB - PRIME DP - Unbound Medicine ER -