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Associations between classical cardiovascular risk factors and coronary artery disease in two countries at contrasting risk for myocardial infarction: the PRIME study.
Int J Cardiol 2000; 74(2-3):191-8IJ

Abstract

PURPOSE

In two countries with contrasting risk for coronary artery disease (CAD)-Northern Ireland and France-a case-control study was performed on baseline data within a cohort study to compare the strength of the associations between CAD prevalence and classical risk factors.

METHOD AND RESULTS

A sample of 9561 men, aged 50-60 years, was studied: 382 had had myocardial infarction or angina, and 9179 were controls. In both countries, variables associated with CAD were age, body mass index, hypertension, diabetes, family history of myocardial infarction (MI), tobacco consumption, triglycerides, HDL-cholesterol, apolipoprotein A-I and B levels. Logistic regression analyses were conducted using standardized odds ratios. The strength of the associations with CAD was rather similar in the two countries (Northern Ireland versus France) for age [1.26 (1.10-1. 45) vs. 1.41 (1.17-1.69)], family history of MI [1.50 (1.04-2.15) vs. 1.83 (0.99-3.37)], hypertension [1.49 (1.13-1.97) vs. 1.67 (1.14-2. 44)], diabetes [5.42 (2.53-11.60) vs. 2.24 (1.06-4.73)], tobacco consumption [1.43 (1.27-1.60) vs. 1.39 (1.22-1.58)], HDL-cholesterol [0.80 (0.68-0.94) vs. 0.86 (0.70-1.06)] and triglyceride levels [1. 17 (1.01-1.36) vs. 1.10 (0.91-1.32)]. Discrepancies concerned lipoprotein(a) [1.22 (1.06-1.40) vs. 0.96 (0.81-1.15), P<0.01], with stronger associations in Northern Ireland than in France.

CONCLUSION

It is concluded that the higher prevalence of CAD in Northern Ireland cannot be explained by major differences in the susceptibility to classical risk factors; the difference in risk of CAD appears mainly related in Northern Ireland to other risk factors including a worse lipid profile and genetic/environmental interactions.

Authors+Show Affiliations

Department of Epidemiology, INSERM U518, Faculty of Medicine, 37 Allées Jules Guesde, 31073 Cedex, Toulouse, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10962121

Citation

Graille, V, et al. "Associations Between Classical Cardiovascular Risk Factors and Coronary Artery Disease in Two Countries at Contrasting Risk for Myocardial Infarction: the PRIME Study." International Journal of Cardiology, vol. 74, no. 2-3, 2000, pp. 191-8.
Graille V, Ferrières J, Evans A, et al. Associations between classical cardiovascular risk factors and coronary artery disease in two countries at contrasting risk for myocardial infarction: the PRIME study. Int J Cardiol. 2000;74(2-3):191-8.
Graille, V., Ferrières, J., Evans, A., Amouyel, P., Arveiler, D., Luc, G., & Ducimetière, P. (2000). Associations between classical cardiovascular risk factors and coronary artery disease in two countries at contrasting risk for myocardial infarction: the PRIME study. International Journal of Cardiology, 74(2-3), pp. 191-8.
Graille V, et al. Associations Between Classical Cardiovascular Risk Factors and Coronary Artery Disease in Two Countries at Contrasting Risk for Myocardial Infarction: the PRIME Study. Int J Cardiol. 2000 Jul 31;74(2-3):191-8. PubMed PMID: 10962121.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations between classical cardiovascular risk factors and coronary artery disease in two countries at contrasting risk for myocardial infarction: the PRIME study. AU - Graille,V, AU - Ferrières,J, AU - Evans,A, AU - Amouyel,P, AU - Arveiler,D, AU - Luc,G, AU - Ducimetière,P, PY - 2000/8/30/pubmed PY - 2001/2/28/medline PY - 2000/8/30/entrez SP - 191 EP - 8 JF - International journal of cardiology JO - Int. J. Cardiol. VL - 74 IS - 2-3 N2 - PURPOSE: In two countries with contrasting risk for coronary artery disease (CAD)-Northern Ireland and France-a case-control study was performed on baseline data within a cohort study to compare the strength of the associations between CAD prevalence and classical risk factors. METHOD AND RESULTS: A sample of 9561 men, aged 50-60 years, was studied: 382 had had myocardial infarction or angina, and 9179 were controls. In both countries, variables associated with CAD were age, body mass index, hypertension, diabetes, family history of myocardial infarction (MI), tobacco consumption, triglycerides, HDL-cholesterol, apolipoprotein A-I and B levels. Logistic regression analyses were conducted using standardized odds ratios. The strength of the associations with CAD was rather similar in the two countries (Northern Ireland versus France) for age [1.26 (1.10-1. 45) vs. 1.41 (1.17-1.69)], family history of MI [1.50 (1.04-2.15) vs. 1.83 (0.99-3.37)], hypertension [1.49 (1.13-1.97) vs. 1.67 (1.14-2. 44)], diabetes [5.42 (2.53-11.60) vs. 2.24 (1.06-4.73)], tobacco consumption [1.43 (1.27-1.60) vs. 1.39 (1.22-1.58)], HDL-cholesterol [0.80 (0.68-0.94) vs. 0.86 (0.70-1.06)] and triglyceride levels [1. 17 (1.01-1.36) vs. 1.10 (0.91-1.32)]. Discrepancies concerned lipoprotein(a) [1.22 (1.06-1.40) vs. 0.96 (0.81-1.15), P<0.01], with stronger associations in Northern Ireland than in France. CONCLUSION: It is concluded that the higher prevalence of CAD in Northern Ireland cannot be explained by major differences in the susceptibility to classical risk factors; the difference in risk of CAD appears mainly related in Northern Ireland to other risk factors including a worse lipid profile and genetic/environmental interactions. SN - 0167-5273 UR - https://www.unboundmedicine.com/medline/citation/10962121/Associations_between_classical_cardiovascular_risk_factors_and_coronary_artery_disease_in_two_countries_at_contrasting_risk_for_myocardial_infarction:_the_PRIME_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167527300002837 DB - PRIME DP - Unbound Medicine ER -