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Alcohol drinking, body mass index and the risk of oral leukoplakia in an Indian population.
Int J Cancer 2000; 88(1):129-34IJ

Abstract

Although tobacco habits have been associated with the risk of oral leukoplakia, alcohol drinking and body mass index (BMI) as risk factors have not been well established. The purpose of this study is to evaluate the independent effects of drinking, BMI, tobacco chewing and smoking on the risk of oral leukoplakia. A case-control study was conducted, with data from an ongoing randomized oral cancer screening trial in Kerala, India. Trained health workers conducted interviews and performed oral visual inspections to identify oral premalignant lesions such as leukoplakia. The logistic regression model in SAS was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI). A total of 927 leukoplakia cases and 47,773 controls were included in the analysis. Ever alcohol drinking was a significant risk factor for oral leukoplakia among nonsmokers (OR=2.1, 95%CI=1.3, 3.4) and non-chewers (OR=1.8, 95%CI=1. 3, 2.5) after adjusting for age, sex, education, BMI and tobacco habits. The association with alcohol drinking was stronger among women (OR=3.9, 95%CI=1.5, 10.4) than men (OR=1.5, 95%CI=1.3, 1.9). An inverse dose-response relationship was observed between BMI and the risk of oral leukoplakia (p for trend=0.0075). Tobacco chewing was a stronger risk factor for women (OR=37.7, 95%CI=24.2, 58.7) than for men (OR=3.4, 95%CI=2.8, 4.1). Smoking was a slightly stronger risk factor for men (OR=3.3, 95%CI=2.5, 4.3) than for women (OR=2.0, 95%CI=1.5, 2.9). In conclusion, alcohol drinking was found to be an independent risk factor while BMI might be inversely associated with the risk of oral leukoplakia in an Indian population.

Authors+Show Affiliations

Department of Epidemiology, UCLA School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, California 90095-1772, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10962450

Citation

Hashibe, M, et al. "Alcohol Drinking, Body Mass Index and the Risk of Oral Leukoplakia in an Indian Population." International Journal of Cancer, vol. 88, no. 1, 2000, pp. 129-34.
Hashibe M, Sankaranarayanan R, Thomas G, et al. Alcohol drinking, body mass index and the risk of oral leukoplakia in an Indian population. Int J Cancer. 2000;88(1):129-34.
Hashibe, M., Sankaranarayanan, R., Thomas, G., Kuruvilla, B., Mathew, B., Somanathan, T., ... Zhang, Z. F. (2000). Alcohol drinking, body mass index and the risk of oral leukoplakia in an Indian population. International Journal of Cancer, 88(1), pp. 129-34.
Hashibe M, et al. Alcohol Drinking, Body Mass Index and the Risk of Oral Leukoplakia in an Indian Population. Int J Cancer. 2000 Oct 1;88(1):129-34. PubMed PMID: 10962450.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol drinking, body mass index and the risk of oral leukoplakia in an Indian population. AU - Hashibe,M, AU - Sankaranarayanan,R, AU - Thomas,G, AU - Kuruvilla,B, AU - Mathew,B, AU - Somanathan,T, AU - Parkin,D M, AU - Zhang,Z F, PY - 2000/8/30/pubmed PY - 2000/9/30/medline PY - 2000/8/30/entrez SP - 129 EP - 34 JF - International journal of cancer JO - Int. J. Cancer VL - 88 IS - 1 N2 - Although tobacco habits have been associated with the risk of oral leukoplakia, alcohol drinking and body mass index (BMI) as risk factors have not been well established. The purpose of this study is to evaluate the independent effects of drinking, BMI, tobacco chewing and smoking on the risk of oral leukoplakia. A case-control study was conducted, with data from an ongoing randomized oral cancer screening trial in Kerala, India. Trained health workers conducted interviews and performed oral visual inspections to identify oral premalignant lesions such as leukoplakia. The logistic regression model in SAS was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI). A total of 927 leukoplakia cases and 47,773 controls were included in the analysis. Ever alcohol drinking was a significant risk factor for oral leukoplakia among nonsmokers (OR=2.1, 95%CI=1.3, 3.4) and non-chewers (OR=1.8, 95%CI=1. 3, 2.5) after adjusting for age, sex, education, BMI and tobacco habits. The association with alcohol drinking was stronger among women (OR=3.9, 95%CI=1.5, 10.4) than men (OR=1.5, 95%CI=1.3, 1.9). An inverse dose-response relationship was observed between BMI and the risk of oral leukoplakia (p for trend=0.0075). Tobacco chewing was a stronger risk factor for women (OR=37.7, 95%CI=24.2, 58.7) than for men (OR=3.4, 95%CI=2.8, 4.1). Smoking was a slightly stronger risk factor for men (OR=3.3, 95%CI=2.5, 4.3) than for women (OR=2.0, 95%CI=1.5, 2.9). In conclusion, alcohol drinking was found to be an independent risk factor while BMI might be inversely associated with the risk of oral leukoplakia in an Indian population. SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/10962450/Alcohol_drinking_body_mass_index_and_the_risk_of_oral_leukoplakia_in_an_Indian_population_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0020-7136&date=2000&volume=88&issue=1&spage=129 DB - PRIME DP - Unbound Medicine ER -