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[Atovaquone/proguanil. Prophylaxis and treatment of malaria].
Ugeskr Laeger. 2000 Jul 31; 162(31):4177-81.UL

Abstract

Malarone is a combination of the two drugs atovaquone and proguanil. Malarone is useful as prophylaxis and for the treatment of falciparum malaria. Monotherapy using atovaquone or proguanil results in treatment failure in 30% and 90% respectively, whereas treatment failure is rare when a combination of the drugs is used (< 2%). This reflects the synergistic effect of this drug combination. Used as a chemoprophylaticum against falciparum malaria Malarone has an effect of > 95%. The protective mechanism is likely to act via the mitochondrial cytochrome bc complex, thus a different mechanism from other malaria drugs. For this reason, cross-resistance with other malaria drugs is not expected. The documentation of effect and safety profile of Malarone in malaria prophylaxis makes it a suitable alternative to mefloquine and doxycycline in case of contraindications. Malarone is effective for the treatment of acute uncomplicated malaria, and may be used as an alternative to mefloquine.

Authors+Show Affiliations

H:S Hvidovre Hospital, infektionsmedicinsk afdeling. j.d.lundgren@inet.uni2.dkNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

dan

PubMed ID

10962933

Citation

Lundgren, J D., and U B. Dragsted. "[Atovaquone/proguanil. Prophylaxis and Treatment of Malaria]." Ugeskrift for Laeger, vol. 162, no. 31, 2000, pp. 4177-81.
Lundgren JD, Dragsted UB. [Atovaquone/proguanil. Prophylaxis and treatment of malaria]. Ugeskr Laeger. 2000;162(31):4177-81.
Lundgren, J. D., & Dragsted, U. B. (2000). [Atovaquone/proguanil. Prophylaxis and treatment of malaria]. Ugeskrift for Laeger, 162(31), 4177-81.
Lundgren JD, Dragsted UB. [Atovaquone/proguanil. Prophylaxis and Treatment of Malaria]. Ugeskr Laeger. 2000 Jul 31;162(31):4177-81. PubMed PMID: 10962933.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Atovaquone/proguanil. Prophylaxis and treatment of malaria]. AU - Lundgren,J D, AU - Dragsted,U B, PY - 2000/8/30/pubmed PY - 2000/9/19/medline PY - 2000/8/30/entrez SP - 4177 EP - 81 JF - Ugeskrift for laeger JO - Ugeskr Laeger VL - 162 IS - 31 N2 - Malarone is a combination of the two drugs atovaquone and proguanil. Malarone is useful as prophylaxis and for the treatment of falciparum malaria. Monotherapy using atovaquone or proguanil results in treatment failure in 30% and 90% respectively, whereas treatment failure is rare when a combination of the drugs is used (< 2%). This reflects the synergistic effect of this drug combination. Used as a chemoprophylaticum against falciparum malaria Malarone has an effect of > 95%. The protective mechanism is likely to act via the mitochondrial cytochrome bc complex, thus a different mechanism from other malaria drugs. For this reason, cross-resistance with other malaria drugs is not expected. The documentation of effect and safety profile of Malarone in malaria prophylaxis makes it a suitable alternative to mefloquine and doxycycline in case of contraindications. Malarone is effective for the treatment of acute uncomplicated malaria, and may be used as an alternative to mefloquine. SN - 0041-5782 UR - https://www.unboundmedicine.com/medline/citation/10962933/[Atovaquone/proguanil__Prophylaxis_and_treatment_of_malaria]_ L2 - http://www.diseaseinfosearch.org/result/4415 DB - PRIME DP - Unbound Medicine ER -