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The importance of selenium to human health.
Lancet 2000; 356(9225):233-41Lct

Abstract

The essential trace mineral, selenium, is of fundamental importance to human health. As a constituent of selenoproteins, selenium has structural and enzymic roles, in the latter context being best-known as an antioxidant and catalyst for the production of active thyroid hormone. Selenium is needed for the proper functioning of the immune system, and appears to be a key nutrient in counteracting the development of virulence and inhibiting HIV progression to AIDS. It is required for sperm motility and may reduce the risk of miscarriage. Deficiency has been linked to adverse mood states. Findings have been equivocal in linking selenium to cardiovascular disease risk although other conditions involving oxidative stress and inflammation have shown benefits of a higher selenium status. An elevated selenium intake may be associated with reduced cancer risk. Large clinical trials are now planned to confirm or refute this hypothesis. In the context of these health effects, low or diminishing selenium status in some parts of the world, notably in some European countries, is giving cause for concern.

Authors+Show Affiliations

Centre for Nutrition and Food Safety, School of Biological Sciences, University of Surrey, Guildford, UK.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

10963212

Citation

Rayman, M P.. "The Importance of Selenium to Human Health." Lancet (London, England), vol. 356, no. 9225, 2000, pp. 233-41.
Rayman MP. The importance of selenium to human health. Lancet. 2000;356(9225):233-41.
Rayman, M. P. (2000). The importance of selenium to human health. Lancet (London, England), 356(9225), pp. 233-41.
Rayman MP. The Importance of Selenium to Human Health. Lancet. 2000 Jul 15;356(9225):233-41. PubMed PMID: 10963212.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The importance of selenium to human health. A1 - Rayman,M P, PY - 2000/8/30/pubmed PY - 2000/9/19/medline PY - 2000/8/30/entrez SP - 233 EP - 41 JF - Lancet (London, England) JO - Lancet VL - 356 IS - 9225 N2 - The essential trace mineral, selenium, is of fundamental importance to human health. As a constituent of selenoproteins, selenium has structural and enzymic roles, in the latter context being best-known as an antioxidant and catalyst for the production of active thyroid hormone. Selenium is needed for the proper functioning of the immune system, and appears to be a key nutrient in counteracting the development of virulence and inhibiting HIV progression to AIDS. It is required for sperm motility and may reduce the risk of miscarriage. Deficiency has been linked to adverse mood states. Findings have been equivocal in linking selenium to cardiovascular disease risk although other conditions involving oxidative stress and inflammation have shown benefits of a higher selenium status. An elevated selenium intake may be associated with reduced cancer risk. Large clinical trials are now planned to confirm or refute this hypothesis. In the context of these health effects, low or diminishing selenium status in some parts of the world, notably in some European countries, is giving cause for concern. SN - 0140-6736 UR - https://www.unboundmedicine.com/medline/citation/10963212/The_importance_of_selenium_to_human_health_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(00)02490-9 DB - PRIME DP - Unbound Medicine ER -