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Oxidative stress and genetics in the pathogenesis of Parkinson's disease.
Neurobiol Dis. 2000 Aug; 7(4):240-50.ND

Abstract

Parkinson's Disease (PD) is the second most common chronic neurodegenerative disease characterized by the progressive loss of dopamine neurons, leading to rigidity, slowness of movement, rest tremor, gait disturbances, and imbalance. Although there is effective symptomatic treatment for PD, there is no proven preventative or regenerative therapy. The etiology of this disorder remains unknown. Recent genetic studies have identified mutations in alpha-synuclein as a rare cause of autosomal dominant familial PD and mutations in parkin as a cause of autosomal recessive familial PD. The more common sporadic form of PD is thought to be due to oxidative stress and derangements in mitochondrial complex I activity. Understanding the mechanism by which familial linked mutations and oxidative stress cause PD has tremendous potential for unraveling the mechanisms of dopamine cell death in PD. In this article, we review recent advances in the understanding of the role of genetics and oxidative stress in the pathogenesis of PD.

Authors+Show Affiliations

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

10964596

Citation

Zhang, Y, et al. "Oxidative Stress and Genetics in the Pathogenesis of Parkinson's Disease." Neurobiology of Disease, vol. 7, no. 4, 2000, pp. 240-50.
Zhang Y, Dawson VL, Dawson TM. Oxidative stress and genetics in the pathogenesis of Parkinson's disease. Neurobiol Dis. 2000;7(4):240-50.
Zhang, Y., Dawson, V. L., & Dawson, T. M. (2000). Oxidative stress and genetics in the pathogenesis of Parkinson's disease. Neurobiology of Disease, 7(4), 240-50.
Zhang Y, Dawson VL, Dawson TM. Oxidative Stress and Genetics in the Pathogenesis of Parkinson's Disease. Neurobiol Dis. 2000;7(4):240-50. PubMed PMID: 10964596.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative stress and genetics in the pathogenesis of Parkinson's disease. AU - Zhang,Y, AU - Dawson,V L, AU - Dawson,T M, PY - 2000/8/31/pubmed PY - 2000/10/14/medline PY - 2000/8/31/entrez SP - 240 EP - 50 JF - Neurobiology of disease JO - Neurobiol Dis VL - 7 IS - 4 N2 - Parkinson's Disease (PD) is the second most common chronic neurodegenerative disease characterized by the progressive loss of dopamine neurons, leading to rigidity, slowness of movement, rest tremor, gait disturbances, and imbalance. Although there is effective symptomatic treatment for PD, there is no proven preventative or regenerative therapy. The etiology of this disorder remains unknown. Recent genetic studies have identified mutations in alpha-synuclein as a rare cause of autosomal dominant familial PD and mutations in parkin as a cause of autosomal recessive familial PD. The more common sporadic form of PD is thought to be due to oxidative stress and derangements in mitochondrial complex I activity. Understanding the mechanism by which familial linked mutations and oxidative stress cause PD has tremendous potential for unraveling the mechanisms of dopamine cell death in PD. In this article, we review recent advances in the understanding of the role of genetics and oxidative stress in the pathogenesis of PD. SN - 0969-9961 UR - https://www.unboundmedicine.com/medline/citation/10964596/Oxidative_stress_and_genetics_in_the_pathogenesis_of_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0969-9961(00)90319-X DB - PRIME DP - Unbound Medicine ER -