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Influence of human immunodeficiency virus status on the clinical history of herpes simplex keratitis.
Ophthalmologica 2000 Sep-Oct; 214(5):337-40O

Abstract

Human immunodeficiency virus (HIV) infection is associated with a wide spectrum of systemic and ocular infectious diseases. Little is known about its association with herpes simplex keratitis (HSK) in this geographical region (South India). A retrospective study was undertaken to analyze this association in a cohort of 30 virologically proven recurrent HSK cases. Laboratory methods included herpes simplex virus (HSV) isolation, HSV antigen detection and tear secretory IgA or HSV DNA detection while commercial ELISA kits detected HIV infection. The rationale behind the HIV screening was to assess the role of HIV with increased HSK recurrences. Confirmed HIV seropositivity was 16.7% in recurrent HSK cases as against 3.3% in the matched first-episode HSK cases (p < 0.05, Fisher's exact test). Our observations on the features of herpetic keratitis in HIV-proven patients, though based on a small number of cases, raise the question whether the immunological abnormalities associated with HIV/AIDS may affect the clinical course of HSK.

Authors+Show Affiliations

Department of Microbiology, Dr. ALM Postgraduate Institute of Basic Medical Sciences, University of Madras, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10965247

Citation

Pramod, N P., et al. "Influence of Human Immunodeficiency Virus Status On the Clinical History of Herpes Simplex Keratitis." Ophthalmologica. Journal International D'ophtalmologie. International Journal of Ophthalmology. Zeitschrift Fur Augenheilkunde, vol. 214, no. 5, 2000, pp. 337-40.
Pramod NP, Hari R, Sudhamathi K, et al. Influence of human immunodeficiency virus status on the clinical history of herpes simplex keratitis. Ophthalmologica. 2000;214(5):337-40.
Pramod, N. P., Hari, R., Sudhamathi, K., Ananadakannan, K., & Thyagarajan, S. P. (2000). Influence of human immunodeficiency virus status on the clinical history of herpes simplex keratitis. Ophthalmologica. Journal International D'ophtalmologie. International Journal of Ophthalmology. Zeitschrift Fur Augenheilkunde, 214(5), pp. 337-40.
Pramod NP, et al. Influence of Human Immunodeficiency Virus Status On the Clinical History of Herpes Simplex Keratitis. Ophthalmologica. 2000;214(5):337-40. PubMed PMID: 10965247.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of human immunodeficiency virus status on the clinical history of herpes simplex keratitis. AU - Pramod,N P, AU - Hari,R, AU - Sudhamathi,K, AU - Ananadakannan,K, AU - Thyagarajan,S P, PY - 2000/8/31/pubmed PY - 2000/10/7/medline PY - 2000/8/31/entrez SP - 337 EP - 40 JF - Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde JO - Ophthalmologica VL - 214 IS - 5 N2 - Human immunodeficiency virus (HIV) infection is associated with a wide spectrum of systemic and ocular infectious diseases. Little is known about its association with herpes simplex keratitis (HSK) in this geographical region (South India). A retrospective study was undertaken to analyze this association in a cohort of 30 virologically proven recurrent HSK cases. Laboratory methods included herpes simplex virus (HSV) isolation, HSV antigen detection and tear secretory IgA or HSV DNA detection while commercial ELISA kits detected HIV infection. The rationale behind the HIV screening was to assess the role of HIV with increased HSK recurrences. Confirmed HIV seropositivity was 16.7% in recurrent HSK cases as against 3.3% in the matched first-episode HSK cases (p < 0.05, Fisher's exact test). Our observations on the features of herpetic keratitis in HIV-proven patients, though based on a small number of cases, raise the question whether the immunological abnormalities associated with HIV/AIDS may affect the clinical course of HSK. SN - 0030-3755 UR - https://www.unboundmedicine.com/medline/citation/10965247/Influence_of_human_immunodeficiency_virus_status_on_the_clinical_history_of_herpes_simplex_keratitis_ L2 - https://www.karger.com?DOI=10.1159/000027516 DB - PRIME DP - Unbound Medicine ER -