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Bile and acid reflux in long and short segment Barrett's esophagus, and in reflux disease.
Z Gastroenterol. 2000 Jul; 38(7):565-70.ZG

Abstract

Gastroesophageal acid reflux (GER) is the primary risk factor for gastroesophageal reflux disease (GERD). In long segment Barrett's esophagus (LSBE) duodenogastroesophageal reflux (DGER) parallels acid reflux. The role of GER and DGER in short segment Barrett's esophagus (SSBE) remains to be determined. The aim of the present prospective study was to investigate the esophageal bile and acid reflux in patients with LSBE, SSBE and patients with GERD. Three groups of patients were studied: Patients with LSBE (n = 12), SSBE (n = 20) and patients with GERD without intestinal metaplasia (n = 33). Subjects underwent esophageal manometry and simultaneous 24-h pH and bile monitoring (Bilitec 2000). The thresholds for GER and DGER were a deMeester score > 14.7 and an absorbance value > 0.2 for 10.9% of total period, respectively. GER did not differ between the groups (p > 0.05). However, DGER differed between patients with LSBE, SSBE and GERD (14.7 vs 2.1 vs 2.1, respectively; p < 0.05). H. pylori status did not influence GER and DGER significantly. In contrast to patients with LSBE the DGER does not seem to play an important role in patients with SSBE and patients with GERD. This result indicates a different etiopathology of both long and short segment Barrett's esophagus.

Authors+Show Affiliations

Medizinische Klinik 1, Städtisches Klinikum Solingen, Akademisches Lehrkrankenhaus, Universität Köln. pfaffenbach@KlinikumSolingen.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

10965553

Citation

Pfaffenbach, B, et al. "Bile and Acid Reflux in Long and Short Segment Barrett's Esophagus, and in Reflux Disease." Zeitschrift Fur Gastroenterologie, vol. 38, no. 7, 2000, pp. 565-70.
Pfaffenbach B, Hullerum J, Orth KH, et al. Bile and acid reflux in long and short segment Barrett's esophagus, and in reflux disease. Z Gastroenterol. 2000;38(7):565-70.
Pfaffenbach, B., Hullerum, J., Orth, K. H., Langer, M., Stabenow-Lohbauer, U., & Lux, G. (2000). Bile and acid reflux in long and short segment Barrett's esophagus, and in reflux disease. Zeitschrift Fur Gastroenterologie, 38(7), 565-70.
Pfaffenbach B, et al. Bile and Acid Reflux in Long and Short Segment Barrett's Esophagus, and in Reflux Disease. Z Gastroenterol. 2000;38(7):565-70. PubMed PMID: 10965553.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bile and acid reflux in long and short segment Barrett's esophagus, and in reflux disease. AU - Pfaffenbach,B, AU - Hullerum,J, AU - Orth,K H, AU - Langer,M, AU - Stabenow-Lohbauer,U, AU - Lux,G, PY - 2000/8/31/pubmed PY - 2000/10/21/medline PY - 2000/8/31/entrez SP - 565 EP - 70 JF - Zeitschrift fur Gastroenterologie JO - Z Gastroenterol VL - 38 IS - 7 N2 - Gastroesophageal acid reflux (GER) is the primary risk factor for gastroesophageal reflux disease (GERD). In long segment Barrett's esophagus (LSBE) duodenogastroesophageal reflux (DGER) parallels acid reflux. The role of GER and DGER in short segment Barrett's esophagus (SSBE) remains to be determined. The aim of the present prospective study was to investigate the esophageal bile and acid reflux in patients with LSBE, SSBE and patients with GERD. Three groups of patients were studied: Patients with LSBE (n = 12), SSBE (n = 20) and patients with GERD without intestinal metaplasia (n = 33). Subjects underwent esophageal manometry and simultaneous 24-h pH and bile monitoring (Bilitec 2000). The thresholds for GER and DGER were a deMeester score > 14.7 and an absorbance value > 0.2 for 10.9% of total period, respectively. GER did not differ between the groups (p > 0.05). However, DGER differed between patients with LSBE, SSBE and GERD (14.7 vs 2.1 vs 2.1, respectively; p < 0.05). H. pylori status did not influence GER and DGER significantly. In contrast to patients with LSBE the DGER does not seem to play an important role in patients with SSBE and patients with GERD. This result indicates a different etiopathology of both long and short segment Barrett's esophagus. SN - 0044-2771 UR - https://www.unboundmedicine.com/medline/citation/10965553/Bile_and_acid_reflux_in_long_and_short_segment_Barrett's_esophagus_and_in_reflux_disease_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2000-7450 DB - PRIME DP - Unbound Medicine ER -