Tags

Type your tag names separated by a space and hit enter

Alpha-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson's disease.
Acta Neuropathol. 2000 Sep; 100(3):285-90.AN

Abstract

Amygdala, hippocampus and six cortical gyri were examined for the Lewy body (LB) degeneration and Alzheimer's disease (AD) type changes in 45 patients with Parkinson's disease (PD). For detection of LBs, the brain areas were stained with an antibody against alpha-synuclein. The extent of neuropathological lesions was investigated in relation to cognitive dysfunction and apolipoprotein E (apoE) epsilon4 allele dosage. At least one cortical LB was found in 95% of cases (43/45). Furthermore, 40% of cases (18/45) had histological findings of definite AD (CERAD class C). Those PD cases with the apoE epsilon4 allele had a significantly greater number of cortical LBs than those without the apoE epsilon4 allele, but this was statistically significant only in precentral, angular and temporal gyri. The LB density correlated better with the number of plaques than with the density of tangles. The number of LBs in several cortical areas correlated significantly with the cognitive impairment. In stepwise linear regression analysis, the number of LBs in the cingulate gyrus and the amount of tangles in the temporal cortex remained statistically significant. When the CERAD class C was excluded, the correlation between cognitive decline and the number of LBs in cortical areas became even more pronounced. A stepwise linear regression analysis in these cases found the number of LBs in the frontal gyrus to be the statistically most significant predictor of cognitive impairment. This study shows, for the first time, that in PD, alpha-synuclein-positive cortical LBs are associated with cognitive impairment independent of AD-type pathology.

Authors+Show Affiliations

Department of Pathology, University of Turku, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10965798

Citation

Mattila, P M., et al. "Alpha-synuclein-immunoreactive Cortical Lewy Bodies Are Associated With Cognitive Impairment in Parkinson's Disease." Acta Neuropathologica, vol. 100, no. 3, 2000, pp. 285-90.
Mattila PM, Rinne JO, Helenius H, et al. Alpha-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson's disease. Acta Neuropathol. 2000;100(3):285-90.
Mattila, P. M., Rinne, J. O., Helenius, H., Dickson, D. W., & Röyttä, M. (2000). Alpha-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson's disease. Acta Neuropathologica, 100(3), 285-90.
Mattila PM, et al. Alpha-synuclein-immunoreactive Cortical Lewy Bodies Are Associated With Cognitive Impairment in Parkinson's Disease. Acta Neuropathol. 2000;100(3):285-90. PubMed PMID: 10965798.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alpha-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson's disease. AU - Mattila,P M, AU - Rinne,J O, AU - Helenius,H, AU - Dickson,D W, AU - Röyttä,M, PY - 2000/8/31/pubmed PY - 2001/2/28/medline PY - 2000/8/31/entrez SP - 285 EP - 90 JF - Acta neuropathologica JO - Acta Neuropathol VL - 100 IS - 3 N2 - Amygdala, hippocampus and six cortical gyri were examined for the Lewy body (LB) degeneration and Alzheimer's disease (AD) type changes in 45 patients with Parkinson's disease (PD). For detection of LBs, the brain areas were stained with an antibody against alpha-synuclein. The extent of neuropathological lesions was investigated in relation to cognitive dysfunction and apolipoprotein E (apoE) epsilon4 allele dosage. At least one cortical LB was found in 95% of cases (43/45). Furthermore, 40% of cases (18/45) had histological findings of definite AD (CERAD class C). Those PD cases with the apoE epsilon4 allele had a significantly greater number of cortical LBs than those without the apoE epsilon4 allele, but this was statistically significant only in precentral, angular and temporal gyri. The LB density correlated better with the number of plaques than with the density of tangles. The number of LBs in several cortical areas correlated significantly with the cognitive impairment. In stepwise linear regression analysis, the number of LBs in the cingulate gyrus and the amount of tangles in the temporal cortex remained statistically significant. When the CERAD class C was excluded, the correlation between cognitive decline and the number of LBs in cortical areas became even more pronounced. A stepwise linear regression analysis in these cases found the number of LBs in the frontal gyrus to be the statistically most significant predictor of cognitive impairment. This study shows, for the first time, that in PD, alpha-synuclein-positive cortical LBs are associated with cognitive impairment independent of AD-type pathology. SN - 0001-6322 UR - https://www.unboundmedicine.com/medline/citation/10965798/Alpha_synuclein_immunoreactive_cortical_Lewy_bodies_are_associated_with_cognitive_impairment_in_Parkinson's_disease_ L2 - https://dx.doi.org/10.1007/s004019900168 DB - PRIME DP - Unbound Medicine ER -