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Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women.

Abstract

BACKGROUND

No published studies have directly examined the effect of soy protein with isoflavones on bone or bone turnover in perimenopausal women.

OBJECTIVE

Our objective was to determine the effects of 24 wk of consumption of soy protein isolate with isoflavones (80.4 mg/d) in attenuating bone loss during the menopausal transition.

DESIGN

Perimenopausal subjects were randomly assigned, double blind, to treatment: isoflavone-rich soy (SPI+; n = 24), isoflavone-poor soy (SPI-; n = 24), or whey (control; n = 21) protein. At baseline and posttreatment, lumbar spine bone mineral density (BMD) and bone mineral content (BMC) were measured by using dual-energy X-ray absorptiometry. At baseline, midtreatment, and posttreatment, urinary N:-telopeptides and serum bone-specific alkaline phosphatase (BAP) were measured.

RESULTS

The percentage change in lumbar spine BMD and BMC, respectively, did not differ from zero in the SPI+ or SPI- groups, but loss occurred in the control group (-1.28%, P: = 0.0041; -1.73%, P: = 0.0037). By regression analysis, SPI+ treatment had a positive effect on change in BMD (5.6%; P: = 0.023) and BMC (10.1%; P: = 0.0032). Baseline BMD and BMC (P: < or = 0.0001) negatively affected the percentage change in their respective models; baseline body weight (P: = 0.0036) and bone-free lean weight (P: = 0.016) contributed positively to percentage change in BMD and BMC, respectively. Serum BAP posttreatment was negatively related to percentage change in BMD (P: = 0.0016) and BMC (P: = 0.019). Contrast coding using analyses of covariance with BMD or BMC as the outcome showed that isoflavones, not soy protein, exerted the effect.

CONCLUSION

Soy isoflavones attenuated bone loss from the lumbar spine in perimenopausal women.

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  • Authors+Show Affiliations

    ,

    Department of Food Science and Human Nutrition, Human Metabolic Unit, Center for Designing Foods to Improve Nutrition, the Department of Statistics, Iowa State University, Ames 50011-1120, USA. alekel@iastate.edu

    , , , ,

    Source

    MeSH

    Adult
    Biomarkers
    Bone and Bones
    Diet
    Double-Blind Method
    Female
    Humans
    Isoflavones
    Lumbar Vertebrae
    Middle Aged
    Osteoporosis
    Osteoporosis, Postmenopausal
    Patient Compliance
    Premenopause
    Soybean Proteins

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, Non-P.H.S.

    Language

    eng

    PubMed ID

    10966908

    Citation

    Alekel, D L., et al. "Isoflavone-rich Soy Protein Isolate Attenuates Bone Loss in the Lumbar Spine of Perimenopausal Women." The American Journal of Clinical Nutrition, vol. 72, no. 3, 2000, pp. 844-52.
    Alekel DL, Germain AS, Peterson CT, et al. Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women. Am J Clin Nutr. 2000;72(3):844-52.
    Alekel, D. L., Germain, A. S., Peterson, C. T., Hanson, K. B., Stewart, J. W., & Toda, T. (2000). Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women. The American Journal of Clinical Nutrition, 72(3), pp. 844-52.
    Alekel DL, et al. Isoflavone-rich Soy Protein Isolate Attenuates Bone Loss in the Lumbar Spine of Perimenopausal Women. Am J Clin Nutr. 2000;72(3):844-52. PubMed PMID: 10966908.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women. AU - Alekel,D L, AU - Germain,A S, AU - Peterson,C T, AU - Hanson,K B, AU - Stewart,J W, AU - Toda,T, PY - 2000/9/1/pubmed PY - 2000/9/30/medline PY - 2000/9/1/entrez SP - 844 EP - 52 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 72 IS - 3 N2 - BACKGROUND: No published studies have directly examined the effect of soy protein with isoflavones on bone or bone turnover in perimenopausal women. OBJECTIVE: Our objective was to determine the effects of 24 wk of consumption of soy protein isolate with isoflavones (80.4 mg/d) in attenuating bone loss during the menopausal transition. DESIGN: Perimenopausal subjects were randomly assigned, double blind, to treatment: isoflavone-rich soy (SPI+; n = 24), isoflavone-poor soy (SPI-; n = 24), or whey (control; n = 21) protein. At baseline and posttreatment, lumbar spine bone mineral density (BMD) and bone mineral content (BMC) were measured by using dual-energy X-ray absorptiometry. At baseline, midtreatment, and posttreatment, urinary N:-telopeptides and serum bone-specific alkaline phosphatase (BAP) were measured. RESULTS: The percentage change in lumbar spine BMD and BMC, respectively, did not differ from zero in the SPI+ or SPI- groups, but loss occurred in the control group (-1.28%, P: = 0.0041; -1.73%, P: = 0.0037). By regression analysis, SPI+ treatment had a positive effect on change in BMD (5.6%; P: = 0.023) and BMC (10.1%; P: = 0.0032). Baseline BMD and BMC (P: < or = 0.0001) negatively affected the percentage change in their respective models; baseline body weight (P: = 0.0036) and bone-free lean weight (P: = 0.016) contributed positively to percentage change in BMD and BMC, respectively. Serum BAP posttreatment was negatively related to percentage change in BMD (P: = 0.0016) and BMC (P: = 0.019). Contrast coding using analyses of covariance with BMD or BMC as the outcome showed that isoflavones, not soy protein, exerted the effect. CONCLUSION: Soy isoflavones attenuated bone loss from the lumbar spine in perimenopausal women. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/10966908/Isoflavone_rich_soy_protein_isolate_attenuates_bone_loss_in_the_lumbar_spine_of_perimenopausal_women_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/72.3.844 DB - PRIME DP - Unbound Medicine ER -