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Deaths in visceral leishmaniasis (Kala-azar) during treatment.
Med J Malaysia. 1996 Mar; 51(1):29-32.MJ

Abstract

Twenty-seven out of five hundred and fifty three patients hospitalized for visceral leishmaniasis (Kala-azar) died during treatment with sodium antimony gluconate. Data from these patients were evaluated to find out the cause of death. Eight patients had associated diseases such as pulmonary tuberculosis (3), severe malnutrition (1), acute gastroenteritis (1), spleenic infarction (1), acute renal failure (1) and atrial septal defect (1) which could be attributed to death. Twelve patients developed spontaneous haemorrhages from nose, gums and gastrointestinal tract and died, despite of adequate supportive measures. Seven other patients who were improving slowly with antimony therapy died unexpectedly. Though, cause of death could be explained in some patients with associated disease conditions, it could not be explained in others as significant clinical manifestations, haematological, biochemical and electrocardiographic alterations were not evident prior to death. Our impression is that mortality in Kala-azar patients during standard antimonial therapy is more related to the drug rather than the disease process.

Authors+Show Affiliations

Department of Medicine, Rajshahi Medical College, Bangladesh.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10967976

Citation

Ahasan, H A., et al. "Deaths in Visceral Leishmaniasis (Kala-azar) During Treatment." The Medical Journal of Malaysia, vol. 51, no. 1, 1996, pp. 29-32.
Ahasan HA, Chowdhury MA, Azhar MA, et al. Deaths in visceral leishmaniasis (Kala-azar) during treatment. Med J Malaysia. 1996;51(1):29-32.
Ahasan, H. A., Chowdhury, M. A., Azhar, M. A., Rafiqueuddin, A. K., & Azad, K. A. (1996). Deaths in visceral leishmaniasis (Kala-azar) during treatment. The Medical Journal of Malaysia, 51(1), 29-32.
Ahasan HA, et al. Deaths in Visceral Leishmaniasis (Kala-azar) During Treatment. Med J Malaysia. 1996;51(1):29-32. PubMed PMID: 10967976.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Deaths in visceral leishmaniasis (Kala-azar) during treatment. AU - Ahasan,H A, AU - Chowdhury,M A, AU - Azhar,M A, AU - Rafiqueuddin,A K, AU - Azad,K A, PY - 1996/3/1/pubmed PY - 2000/9/23/medline PY - 1996/3/1/entrez SP - 29 EP - 32 JF - The Medical journal of Malaysia JO - Med J Malaysia VL - 51 IS - 1 N2 - Twenty-seven out of five hundred and fifty three patients hospitalized for visceral leishmaniasis (Kala-azar) died during treatment with sodium antimony gluconate. Data from these patients were evaluated to find out the cause of death. Eight patients had associated diseases such as pulmonary tuberculosis (3), severe malnutrition (1), acute gastroenteritis (1), spleenic infarction (1), acute renal failure (1) and atrial septal defect (1) which could be attributed to death. Twelve patients developed spontaneous haemorrhages from nose, gums and gastrointestinal tract and died, despite of adequate supportive measures. Seven other patients who were improving slowly with antimony therapy died unexpectedly. Though, cause of death could be explained in some patients with associated disease conditions, it could not be explained in others as significant clinical manifestations, haematological, biochemical and electrocardiographic alterations were not evident prior to death. Our impression is that mortality in Kala-azar patients during standard antimonial therapy is more related to the drug rather than the disease process. SN - 0300-5283 UR - https://www.unboundmedicine.com/medline/citation/10967976/Deaths_in_visceral_leishmaniasis__Kala_azar__during_treatment_ L2 - http://www.e-mjm.org/1996/v51n1/Visceral_Leishmaniasis.pdf DB - PRIME DP - Unbound Medicine ER -