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Experimental irritant contact dermatitis due to cumulative epicutaneous exposure to sodium lauryl sulphate and toluene: single and concurrent application.
Br J Dermatol. 2000 Sep; 143(3):551-6.BJ

Abstract

In clinical practice, cutaneous exposure to a variety of irritants such as surfactants and solvents is frequent. Although the induction of irritant dermatitis by single irritants has been extensively studied in recent years, our knowledge of the effects of simultaneous application of different irritants is limited. Using non-invasive techniques for measurements of transepidermal water loss (TEWL) and skin colour reflectance, we quantified the irritant effects of single and concurrent application of 0.5% sodium lauryl sulphate (SLS) and undiluted toluene (TOL) in vivo. The irritants were applied twice daily for 30 min to the volar forearms of 20 volunteers. Repeated application of SLS and TOL induced an irritant reaction, as indicated by an increase in TEWL and skin redness. In contrast to SLS alone, the application of TOL alone induced only a moderate increase in TEWL, confirming previous results. Concurrent application of SLS/TOL and TOL/SLS induced significantly stronger reactions than those caused by twice daily application of each irritant on its own. Our results demonstrate that a mixed application of an anionic detergent and an organic solvent has an additive effect on skin irritation. It is suggested that pretreatment with SLS causes an increased susceptibility to TOL irritation and vice versa. Thus, the necessity for special precautions against skin absorption of TOL when handling detergents such as SLS is emphasized.

Authors+Show Affiliations

Department of Dermatology, Friedrich-Schiller-University, Erfurter Str. 35, D-07740 Jena, Germany. wigger@derma.uni-jena.deNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10971328

Citation

Wigger-Alberti, W, et al. "Experimental Irritant Contact Dermatitis Due to Cumulative Epicutaneous Exposure to Sodium Lauryl Sulphate and Toluene: Single and Concurrent Application." The British Journal of Dermatology, vol. 143, no. 3, 2000, pp. 551-6.
Wigger-Alberti W, Krebs A, Elsner P. Experimental irritant contact dermatitis due to cumulative epicutaneous exposure to sodium lauryl sulphate and toluene: single and concurrent application. Br J Dermatol. 2000;143(3):551-6.
Wigger-Alberti, W., Krebs, A., & Elsner, P. (2000). Experimental irritant contact dermatitis due to cumulative epicutaneous exposure to sodium lauryl sulphate and toluene: single and concurrent application. The British Journal of Dermatology, 143(3), 551-6.
Wigger-Alberti W, Krebs A, Elsner P. Experimental Irritant Contact Dermatitis Due to Cumulative Epicutaneous Exposure to Sodium Lauryl Sulphate and Toluene: Single and Concurrent Application. Br J Dermatol. 2000;143(3):551-6. PubMed PMID: 10971328.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Experimental irritant contact dermatitis due to cumulative epicutaneous exposure to sodium lauryl sulphate and toluene: single and concurrent application. AU - Wigger-Alberti,W, AU - Krebs,A, AU - Elsner,P, PY - 2000/9/6/pubmed PY - 2001/2/28/medline PY - 2000/9/6/entrez SP - 551 EP - 6 JF - The British journal of dermatology JO - Br J Dermatol VL - 143 IS - 3 N2 - In clinical practice, cutaneous exposure to a variety of irritants such as surfactants and solvents is frequent. Although the induction of irritant dermatitis by single irritants has been extensively studied in recent years, our knowledge of the effects of simultaneous application of different irritants is limited. Using non-invasive techniques for measurements of transepidermal water loss (TEWL) and skin colour reflectance, we quantified the irritant effects of single and concurrent application of 0.5% sodium lauryl sulphate (SLS) and undiluted toluene (TOL) in vivo. The irritants were applied twice daily for 30 min to the volar forearms of 20 volunteers. Repeated application of SLS and TOL induced an irritant reaction, as indicated by an increase in TEWL and skin redness. In contrast to SLS alone, the application of TOL alone induced only a moderate increase in TEWL, confirming previous results. Concurrent application of SLS/TOL and TOL/SLS induced significantly stronger reactions than those caused by twice daily application of each irritant on its own. Our results demonstrate that a mixed application of an anionic detergent and an organic solvent has an additive effect on skin irritation. It is suggested that pretreatment with SLS causes an increased susceptibility to TOL irritation and vice versa. Thus, the necessity for special precautions against skin absorption of TOL when handling detergents such as SLS is emphasized. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/10971328/Experimental_irritant_contact_dermatitis_due_to_cumulative_epicutaneous_exposure_to_sodium_lauryl_sulphate_and_toluene:_single_and_concurrent_application_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0007-0963&date=2000&volume=143&issue=3&spage=551 DB - PRIME DP - Unbound Medicine ER -