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Remnant-like particle cholesterol and triglyceride levels of hypertriglyceridemic patients in the fed and fasted state.
J Lipid Res. 2000 Sep; 41(9):1428-36.JL

Abstract

Potentially atherogenic triglyceride-rich lipoprotein (TRL) remnants can be isolated and quantitated as remnant-like particles (RLP), using an immunoaffinity gel containing specific anti-human apolipoprotein A-I (apoA-I) and apoB-100 monoclonal antibodies. The aim of the present study was to determine the relationship between postprandial changes in RLP levels and changes in total serum triglyceride (TG) in patients with different forms of hypertriglyceridemia (HTG). Three groups of patients were selected, having similarly elevated serum TG levels: a) HTG with TRL remnant accumulation (i.e., type III patients, n = 15, TG: 3.8 +/- 0.2 mm), b) HTG with increased LDL (i.e., type IIb patients, n = 15, TG: 3.7 +/- 0.2 mm), and c) HTG without evidence of remnant or LDL accumulation (i.e., type IV patients, n = 15, TG: 3.9 +/- 0.3 mm). Ingestion of a 45-g fat meal caused a significant increase in serum TG (30;-50%) in all patients. Mean serum TG levels of the three groups were not significantly different at 4 or 6 h after the meal. RLP cholesterol (C) and TG levels increased after the meal in all patients, but these postprandial increases were also not significantly different among groups. Type III patients had significantly higher (P < 0.01) levels of RLP-C and RLP-apoE in the fasted and fed state, and also had significantly higher RLP-C-to-serum TG ratios (P < 0.001) compared with the other groups. These results indicate that 1) RLP-C and RLP-TG levels are significantly increased in the fed versus fasted state in patients with elevated fasting TG levels; 2) patients with different forms of HTG, but similar TG levels, have similar postprandial increases in RLP-C and RLP-TG; and 3) type III patients have significantly elevated levels of RLP-C and RLP-apoE in both the fed and fasted state.

Authors+Show Affiliations

Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Quebec, Canada H2W 1R7.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10974050

Citation

Marcoux, C, et al. "Remnant-like Particle Cholesterol and Triglyceride Levels of Hypertriglyceridemic Patients in the Fed and Fasted State." Journal of Lipid Research, vol. 41, no. 9, 2000, pp. 1428-36.
Marcoux C, Hopkins PN, Wang T, et al. Remnant-like particle cholesterol and triglyceride levels of hypertriglyceridemic patients in the fed and fasted state. J Lipid Res. 2000;41(9):1428-36.
Marcoux, C., Hopkins, P. N., Wang, T., Leary, E. T., Nakajima, K., Davignon, J., & Cohn, J. S. (2000). Remnant-like particle cholesterol and triglyceride levels of hypertriglyceridemic patients in the fed and fasted state. Journal of Lipid Research, 41(9), 1428-36.
Marcoux C, et al. Remnant-like Particle Cholesterol and Triglyceride Levels of Hypertriglyceridemic Patients in the Fed and Fasted State. J Lipid Res. 2000;41(9):1428-36. PubMed PMID: 10974050.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Remnant-like particle cholesterol and triglyceride levels of hypertriglyceridemic patients in the fed and fasted state. AU - Marcoux,C, AU - Hopkins,P N, AU - Wang,T, AU - Leary,E T, AU - Nakajima,K, AU - Davignon,J, AU - Cohn,J S, PY - 2000/9/7/pubmed PY - 2001/2/28/medline PY - 2000/9/7/entrez SP - 1428 EP - 36 JF - Journal of lipid research JO - J Lipid Res VL - 41 IS - 9 N2 - Potentially atherogenic triglyceride-rich lipoprotein (TRL) remnants can be isolated and quantitated as remnant-like particles (RLP), using an immunoaffinity gel containing specific anti-human apolipoprotein A-I (apoA-I) and apoB-100 monoclonal antibodies. The aim of the present study was to determine the relationship between postprandial changes in RLP levels and changes in total serum triglyceride (TG) in patients with different forms of hypertriglyceridemia (HTG). Three groups of patients were selected, having similarly elevated serum TG levels: a) HTG with TRL remnant accumulation (i.e., type III patients, n = 15, TG: 3.8 +/- 0.2 mm), b) HTG with increased LDL (i.e., type IIb patients, n = 15, TG: 3.7 +/- 0.2 mm), and c) HTG without evidence of remnant or LDL accumulation (i.e., type IV patients, n = 15, TG: 3.9 +/- 0.3 mm). Ingestion of a 45-g fat meal caused a significant increase in serum TG (30;-50%) in all patients. Mean serum TG levels of the three groups were not significantly different at 4 or 6 h after the meal. RLP cholesterol (C) and TG levels increased after the meal in all patients, but these postprandial increases were also not significantly different among groups. Type III patients had significantly higher (P < 0.01) levels of RLP-C and RLP-apoE in the fasted and fed state, and also had significantly higher RLP-C-to-serum TG ratios (P < 0.001) compared with the other groups. These results indicate that 1) RLP-C and RLP-TG levels are significantly increased in the fed versus fasted state in patients with elevated fasting TG levels; 2) patients with different forms of HTG, but similar TG levels, have similar postprandial increases in RLP-C and RLP-TG; and 3) type III patients have significantly elevated levels of RLP-C and RLP-apoE in both the fed and fasted state. SN - 0022-2275 UR - https://www.unboundmedicine.com/medline/citation/10974050/Remnant_like_particle_cholesterol_and_triglyceride_levels_of_hypertriglyceridemic_patients_in_the_fed_and_fasted_state_ L2 - http://www.jlr.org/cgi/pmidlookup?view=long&amp;pmid=10974050 DB - PRIME DP - Unbound Medicine ER -