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Motor and sensory demyelinating mononeuropathy multiplex (multifocal motor and sensory demyelinating neuropathy): a separate entity or a variant of chronic inflammatory demyelinating polyneuropathy?
J Peripher Nerv Syst. 1997; 2(4):362-9.JP

Abstract

We report 16 patients with motor and sensory demyelinating mononeuropathy multiplex (MSDMM) or multifocal motor and sensory demyelinating neuropathy (MMSDN). These patients had the clinical pattern of motor and sensory mononeuropathy multiplex, electrophysiological evidence of demyelination including conduction block, and segmental demyelination in the sural nerve biopsy. Sixty per cent of patients had high CSF protein. Eighty per cent of patients showed good responsiveness to steroid treatment. Unlike multifocal motor neuropathy (MMN), MSDMM is characterized by a shorter course, sensory deficits and sensory nerve conduction abnormalities, absence of GM1 antibody in most patients tested, and a good response to steroid therapy. We believe that MSDMM represents a variant of chronic inflammatory demyelinating polyneuropathy (CIDP) and an intermediate link between CIDP and MMN.

Authors+Show Affiliations

Department of Neurology, The University of Alabama at Birmingham, and The Department of Veterans Affairs Medical Center, 35294, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Clinical Trial
Journal Article

Language

eng

PubMed ID

10975745

Citation

Oh, S J., et al. "Motor and Sensory Demyelinating Mononeuropathy Multiplex (multifocal Motor and Sensory Demyelinating Neuropathy): a Separate Entity or a Variant of Chronic Inflammatory Demyelinating Polyneuropathy?" Journal of the Peripheral Nervous System : JPNS, vol. 2, no. 4, 1997, pp. 362-9.
Oh SJ, Claussen GC, Kim DS. Motor and sensory demyelinating mononeuropathy multiplex (multifocal motor and sensory demyelinating neuropathy): a separate entity or a variant of chronic inflammatory demyelinating polyneuropathy? J Peripher Nerv Syst. 1997;2(4):362-9.
Oh, S. J., Claussen, G. C., & Kim, D. S. (1997). Motor and sensory demyelinating mononeuropathy multiplex (multifocal motor and sensory demyelinating neuropathy): a separate entity or a variant of chronic inflammatory demyelinating polyneuropathy? Journal of the Peripheral Nervous System : JPNS, 2(4), 362-9.
Oh SJ, Claussen GC, Kim DS. Motor and Sensory Demyelinating Mononeuropathy Multiplex (multifocal Motor and Sensory Demyelinating Neuropathy): a Separate Entity or a Variant of Chronic Inflammatory Demyelinating Polyneuropathy. J Peripher Nerv Syst. 1997;2(4):362-9. PubMed PMID: 10975745.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Motor and sensory demyelinating mononeuropathy multiplex (multifocal motor and sensory demyelinating neuropathy): a separate entity or a variant of chronic inflammatory demyelinating polyneuropathy? AU - Oh,S J, AU - Claussen,G C, AU - Kim,D S, PY - 1997/1/1/pubmed PY - 2000/9/30/medline PY - 1997/1/1/entrez SP - 362 EP - 9 JF - Journal of the peripheral nervous system : JPNS JO - J Peripher Nerv Syst VL - 2 IS - 4 N2 - We report 16 patients with motor and sensory demyelinating mononeuropathy multiplex (MSDMM) or multifocal motor and sensory demyelinating neuropathy (MMSDN). These patients had the clinical pattern of motor and sensory mononeuropathy multiplex, electrophysiological evidence of demyelination including conduction block, and segmental demyelination in the sural nerve biopsy. Sixty per cent of patients had high CSF protein. Eighty per cent of patients showed good responsiveness to steroid treatment. Unlike multifocal motor neuropathy (MMN), MSDMM is characterized by a shorter course, sensory deficits and sensory nerve conduction abnormalities, absence of GM1 antibody in most patients tested, and a good response to steroid therapy. We believe that MSDMM represents a variant of chronic inflammatory demyelinating polyneuropathy (CIDP) and an intermediate link between CIDP and MMN. SN - 1085-9489 UR - https://www.unboundmedicine.com/medline/citation/10975745/Motor_and_sensory_demyelinating_mononeuropathy_multiplex__multifocal_motor_and_sensory_demyelinating_neuropathy_:_a_separate_entity_or_a_variant_of_chronic_inflammatory_demyelinating_polyneuropathy L2 - http://www.diseaseinfosearch.org/result/4890 DB - PRIME DP - Unbound Medicine ER -