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Type of alcohol consumed and mortality from all causes, coronary heart disease, and cancer.

Abstract

BACKGROUND

Although the J-shaped relation between alcohol intake and mortality has been reproduced in many large cohort studies, the question of whether the effects of beer, wine, and spirits differ remains controversial.

OBJECTIVE

To examine the relation between intake of different types of alcohol and death from all causes, coronary heart disease, and cancer.

DESIGN

Pooled cohort studies in which intake of beer, wine, and spirits; smoking status; educational level; physical activity; and body mass index were assessed at baseline.

SETTING

Copenhagen, Denmark.

PARTICIPANTS

13 064 men and 11 459 women 20 to 98 years of age.

MEASUREMENTS

Number of deaths and time to death from all causes, coronary heart disease, and cancer during follow-up.

RESULTS

During 257 859 person-years of follow-up, 4833 participants died. J-shaped relations were found between total alcohol intake and mortality at various levels of wine intake. Compared with nondrinkers, light drinkers who avoided wine had a relative risk for death from all causes of 0.90 (95% CI, 0.82 to 0.99) and those who drank wine had a relative risk of 0.66 (CI, 0. 55 to 0.77). Heavy drinkers who avoided wine were at higher risk for death from all causes than were heavy drinkers who included wine in their alcohol intake. Wine drinkers had significantly lower mortality from both coronary heart disease and cancer than did non-wine drinkers (P = 0.007 and P = 0.004, respectively).

CONCLUSION

Wine intake may have a beneficial effect on all-cause mortality that is additive to that of alcohol. This effect may be attributable to a reduction in death from both coronary heart disease and cancer.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Institute of Preventive Medicine, Kommunehospitalet, DK-1399 Copenhagen, Denmark.

    , , , , , ,

    Source

    Annals of internal medicine 133:6 2000 Sep 19 pg 411-9

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Alcohol Drinking
    Beer
    Body Mass Index
    Coronary Disease
    Denmark
    Educational Status
    Exercise
    Female
    Follow-Up Studies
    Humans
    Male
    Middle Aged
    Mortality
    Neoplasms
    Poisson Distribution
    Prospective Studies
    Sex Factors
    Smoking
    Wine

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    10975958

    Citation

    Grønbaek, M, et al. "Type of Alcohol Consumed and Mortality From All Causes, Coronary Heart Disease, and Cancer." Annals of Internal Medicine, vol. 133, no. 6, 2000, pp. 411-9.
    Grønbaek M, Becker U, Johansen D, et al. Type of alcohol consumed and mortality from all causes, coronary heart disease, and cancer. Ann Intern Med. 2000;133(6):411-9.
    Grønbaek, M., Becker, U., Johansen, D., Gottschau, A., Schnohr, P., Hein, H. O., ... Sørensen, T. I. (2000). Type of alcohol consumed and mortality from all causes, coronary heart disease, and cancer. Annals of Internal Medicine, 133(6), pp. 411-9.
    Grønbaek M, et al. Type of Alcohol Consumed and Mortality From All Causes, Coronary Heart Disease, and Cancer. Ann Intern Med. 2000 Sep 19;133(6):411-9. PubMed PMID: 10975958.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Type of alcohol consumed and mortality from all causes, coronary heart disease, and cancer. AU - Grønbaek,M, AU - Becker,U, AU - Johansen,D, AU - Gottschau,A, AU - Schnohr,P, AU - Hein,H O, AU - Jensen,G, AU - Sørensen,T I, PY - 2000/9/23/pubmed PY - 2000/9/23/medline PY - 2000/9/23/entrez SP - 411 EP - 9 JF - Annals of internal medicine JO - Ann. Intern. Med. VL - 133 IS - 6 N2 - BACKGROUND: Although the J-shaped relation between alcohol intake and mortality has been reproduced in many large cohort studies, the question of whether the effects of beer, wine, and spirits differ remains controversial. OBJECTIVE: To examine the relation between intake of different types of alcohol and death from all causes, coronary heart disease, and cancer. DESIGN: Pooled cohort studies in which intake of beer, wine, and spirits; smoking status; educational level; physical activity; and body mass index were assessed at baseline. SETTING: Copenhagen, Denmark. PARTICIPANTS: 13 064 men and 11 459 women 20 to 98 years of age. MEASUREMENTS: Number of deaths and time to death from all causes, coronary heart disease, and cancer during follow-up. RESULTS: During 257 859 person-years of follow-up, 4833 participants died. J-shaped relations were found between total alcohol intake and mortality at various levels of wine intake. Compared with nondrinkers, light drinkers who avoided wine had a relative risk for death from all causes of 0.90 (95% CI, 0.82 to 0.99) and those who drank wine had a relative risk of 0.66 (CI, 0. 55 to 0.77). Heavy drinkers who avoided wine were at higher risk for death from all causes than were heavy drinkers who included wine in their alcohol intake. Wine drinkers had significantly lower mortality from both coronary heart disease and cancer than did non-wine drinkers (P = 0.007 and P = 0.004, respectively). CONCLUSION: Wine intake may have a beneficial effect on all-cause mortality that is additive to that of alcohol. This effect may be attributable to a reduction in death from both coronary heart disease and cancer. SN - 0003-4819 UR - https://www.unboundmedicine.com/medline/citation/10975958/Type_of_alcohol_consumed_and_mortality_from_all_causes_coronary_heart_disease_and_cancer_ L2 - https://www.annals.org/article.aspx?volume=133&issue=6&page=411 DB - PRIME DP - Unbound Medicine ER -