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Does the histaminergic system play a role in spinal nociception?
Hokkaido Igaku Zasshi. 2000 Jul; 75(4):275-81.HI

Abstract

The author studied whether the histaminergic system is involved in spinal nociception or not. A nociception-related, slow ventral root potential of rats, which is an integrated output of motoneurons, was recorded as an index of the intensity of nociception when an electric stimulation was applied to the dorsal root. Histamine dissolved in an artificial cerebrospinal fluid caused small reduction in the potential; however, mepyramine (10 nM to 10 microM, as an H1 receptor antagonist), ranitidine (1 nM to 1 microM, as an H2 receptor antagonist), R(-)-alpha-methylhistamine (2 pM to 200 nM, as an H3 receptor agonist), and thioperamide (1 nM to 10 microM, as an H3 receptor antagonist) dose-dependently reduced the potential down to around a half of each control level. These results indicate that the histaminergic system may affect the spinal withdrawal reflex.

Authors+Show Affiliations

Harasawa K
Department of Anesthesiology and Critical Care, Hokkaido University School of Medicine, Sapporo, Japan.

MeSH

AnimalsDose-Response Relationship, DrugHistamineHistamine AgonistsHistamine AntagonistsIn Vitro TechniquesMethylhistaminesMotor NeuronsPainPyrilamineRanitidineRatsSpinal CordSynaptic Transmission

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10976407

Citation

Harasawa, K. "Does the Histaminergic System Play a Role in Spinal Nociception?" [Hokkaido Igaku Zasshi] the Hokkaido Journal of Medical Science, vol. 75, no. 4, 2000, pp. 275-81.
Harasawa K. Does the histaminergic system play a role in spinal nociception? Hokkaido Igaku Zasshi. 2000;75(4):275-81.
Harasawa, K. (2000). Does the histaminergic system play a role in spinal nociception? [Hokkaido Igaku Zasshi] the Hokkaido Journal of Medical Science, 75(4), 275-81.
Harasawa K. Does the Histaminergic System Play a Role in Spinal Nociception. Hokkaido Igaku Zasshi. 2000;75(4):275-81. PubMed PMID: 10976407.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does the histaminergic system play a role in spinal nociception? A1 - Harasawa,K, PY - 2000/9/8/pubmed PY - 2001/2/28/medline PY - 2000/9/8/entrez SP - 275 EP - 81 JF - [Hokkaido igaku zasshi] The Hokkaido journal of medical science JO - Hokkaido Igaku Zasshi VL - 75 IS - 4 N2 - The author studied whether the histaminergic system is involved in spinal nociception or not. A nociception-related, slow ventral root potential of rats, which is an integrated output of motoneurons, was recorded as an index of the intensity of nociception when an electric stimulation was applied to the dorsal root. Histamine dissolved in an artificial cerebrospinal fluid caused small reduction in the potential; however, mepyramine (10 nM to 10 microM, as an H1 receptor antagonist), ranitidine (1 nM to 1 microM, as an H2 receptor antagonist), R(-)-alpha-methylhistamine (2 pM to 200 nM, as an H3 receptor agonist), and thioperamide (1 nM to 10 microM, as an H3 receptor antagonist) dose-dependently reduced the potential down to around a half of each control level. These results indicate that the histaminergic system may affect the spinal withdrawal reflex. SN - 0367-6102 UR - https://www.unboundmedicine.com/medline/citation/10976407/Does_the_histaminergic_system_play_a_role_in_spinal_nociception L2 - https://medlineplus.gov/pain.html DB - PRIME DP - Unbound Medicine ER -