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The ACE gene and Alzheimer's disease susceptibility.
J Med Genet 2000; 37(9):695-7JM

Abstract

A recent study suggested that the insertion (I) allele in intron 16 of the angiotensin converting enzyme gene (ACE) is associated with Alzheimer's disease (AD) risk. In our series of 239 necropsy confirmed late onset AD cases and 342 elderly non-demented controls aged >73 years, we found significantly different ACE genotype distributions in the case and control groups (p=0.007). Homozygotes for both the I and D alleles were associated with a higher risk compared to DI heterozygotes. While the APOE epsilon4 allele was strongly associated with AD risk in our series, we found no evidence for an interaction between the APOE and ACE loci. In addition, no interactions were observed between ACE and gender or age at death of the AD cases. A meta-analysis of all published reports (12 case-control series in total) suggested that both the II and ID ACE genotypes are associated with increased AD risk (odds ratio (OR) for II v DD 1.36, 95% confidence interval (CI)=1.13-1.63, OR for DI v DD 1.33, 95% CI=1.14-1.53, p=0.0002).

Authors+Show Affiliations

Department of Medical Genetics, Wellcome Trust Centre for Molecular Mechanisms in Disease, Cambridge Institute for Medical Research, Wellcome/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10978362

Citation

Narain, Y, et al. "The ACE Gene and Alzheimer's Disease Susceptibility." Journal of Medical Genetics, vol. 37, no. 9, 2000, pp. 695-7.
Narain Y, Yip A, Murphy T, et al. The ACE gene and Alzheimer's disease susceptibility. J Med Genet. 2000;37(9):695-7.
Narain, Y., Yip, A., Murphy, T., Brayne, C., Easton, D., Evans, J. G., ... Rubinsztein, D. C. (2000). The ACE gene and Alzheimer's disease susceptibility. Journal of Medical Genetics, 37(9), pp. 695-7.
Narain Y, et al. The ACE Gene and Alzheimer's Disease Susceptibility. J Med Genet. 2000;37(9):695-7. PubMed PMID: 10978362.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The ACE gene and Alzheimer's disease susceptibility. AU - Narain,Y, AU - Yip,A, AU - Murphy,T, AU - Brayne,C, AU - Easton,D, AU - Evans,J G, AU - Xuereb,J, AU - Cairns,N, AU - Esiri,M M, AU - Furlong,R A, AU - Rubinsztein,D C, PY - 2000/9/9/pubmed PY - 2001/2/28/medline PY - 2000/9/9/entrez SP - 695 EP - 7 JF - Journal of medical genetics JO - J. Med. Genet. VL - 37 IS - 9 N2 - A recent study suggested that the insertion (I) allele in intron 16 of the angiotensin converting enzyme gene (ACE) is associated with Alzheimer's disease (AD) risk. In our series of 239 necropsy confirmed late onset AD cases and 342 elderly non-demented controls aged >73 years, we found significantly different ACE genotype distributions in the case and control groups (p=0.007). Homozygotes for both the I and D alleles were associated with a higher risk compared to DI heterozygotes. While the APOE epsilon4 allele was strongly associated with AD risk in our series, we found no evidence for an interaction between the APOE and ACE loci. In addition, no interactions were observed between ACE and gender or age at death of the AD cases. A meta-analysis of all published reports (12 case-control series in total) suggested that both the II and ID ACE genotypes are associated with increased AD risk (odds ratio (OR) for II v DD 1.36, 95% confidence interval (CI)=1.13-1.63, OR for DI v DD 1.33, 95% CI=1.14-1.53, p=0.0002). SN - 1468-6244 UR - https://www.unboundmedicine.com/medline/citation/10978362/The_ACE_gene_and_Alzheimer's_disease_susceptibility_ L2 - http://jmg.bmj.com/cgi/pmidlookup?view=long&pmid=10978362 DB - PRIME DP - Unbound Medicine ER -