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Premorbid functioning versus duration of untreated psychosis in 1 year outcome in first-episode psychosis.
Schizophr Res. 2000 Sep 29; 45(1-2):1-9.SR

Abstract

OBJECTIVE

This study examines 1year outcome in patients having first-episode non-affective psychosis, with emphasis on Duration of Untreated Psychosis (DUP) and premorbid functioning, in order to clarify how these factors interact.

METHOD

Forty-three consecutively admitted patients were all rated on the Positive and Negative Syndrome Scale (PANSS) and the Global Assessment of Functioning Scale (GAF), both upon hospitalization and at 1year follow-up. In addition, premorbid functioning, DUP, duration of hospitalization, and social functioning were rated.

RESULTS

Fifty-six per cent were in remission, 18% suffered multiple relapses and 26% were continuously psychotic at 1 year follow-up. Both poor premorbid functioning and long DUP are significantly correlated with more negative symptoms and poorer global functioning at follow-up. Long DUP is also significantly correlated with more positive symptoms. Even when we control for other factors, including premorbid functioning and gender, DUP is a strong predictor of outcome. To a limited degree premorbid functioning and DUP interact, but DUP has an independent influence on outcome.

CONCLUSIONS

these findings strengthen the rationale for establishing health service programs for early detection and treatment of first-onset psychosis

Authors+Show Affiliations

Psychiatric Hospital of Rogaland, Armauer Hansensv. 20, Stavanger, Norway. tklarsen@online.noNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10978867

Citation

Larsen, T K., et al. "Premorbid Functioning Versus Duration of Untreated Psychosis in 1 Year Outcome in First-episode Psychosis." Schizophrenia Research, vol. 45, no. 1-2, 2000, pp. 1-9.
Larsen TK, Moe LC, Vibe-Hansen L, et al. Premorbid functioning versus duration of untreated psychosis in 1 year outcome in first-episode psychosis. Schizophr Res. 2000;45(1-2):1-9.
Larsen, T. K., Moe, L. C., Vibe-Hansen, L., & Johannessen, J. O. (2000). Premorbid functioning versus duration of untreated psychosis in 1 year outcome in first-episode psychosis. Schizophrenia Research, 45(1-2), 1-9.
Larsen TK, et al. Premorbid Functioning Versus Duration of Untreated Psychosis in 1 Year Outcome in First-episode Psychosis. Schizophr Res. 2000 Sep 29;45(1-2):1-9. PubMed PMID: 10978867.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Premorbid functioning versus duration of untreated psychosis in 1 year outcome in first-episode psychosis. AU - Larsen,T K, AU - Moe,L C, AU - Vibe-Hansen,L, AU - Johannessen,J O, PY - 2000/9/9/pubmed PY - 2000/10/21/medline PY - 2000/9/9/entrez SP - 1 EP - 9 JF - Schizophrenia research JO - Schizophr Res VL - 45 IS - 1-2 N2 - OBJECTIVE: This study examines 1year outcome in patients having first-episode non-affective psychosis, with emphasis on Duration of Untreated Psychosis (DUP) and premorbid functioning, in order to clarify how these factors interact. METHOD: Forty-three consecutively admitted patients were all rated on the Positive and Negative Syndrome Scale (PANSS) and the Global Assessment of Functioning Scale (GAF), both upon hospitalization and at 1year follow-up. In addition, premorbid functioning, DUP, duration of hospitalization, and social functioning were rated. RESULTS: Fifty-six per cent were in remission, 18% suffered multiple relapses and 26% were continuously psychotic at 1 year follow-up. Both poor premorbid functioning and long DUP are significantly correlated with more negative symptoms and poorer global functioning at follow-up. Long DUP is also significantly correlated with more positive symptoms. Even when we control for other factors, including premorbid functioning and gender, DUP is a strong predictor of outcome. To a limited degree premorbid functioning and DUP interact, but DUP has an independent influence on outcome. CONCLUSIONS: these findings strengthen the rationale for establishing health service programs for early detection and treatment of first-onset psychosis SN - 0920-9964 UR - https://www.unboundmedicine.com/medline/citation/10978867/Premorbid_functioning_versus_duration_of_untreated_psychosis_in_1_year_outcome_in_first_episode_psychosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0920-9964(99)00169-3 DB - PRIME DP - Unbound Medicine ER -