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Association of fractures with caffeine and alcohol in postmenopausal women: the Iowa Women's Health Study.
Public Health Nutr 2000; 3(3):253-61PH

Abstract

OBJECTIVE

To assess whether alcoholic and caffeinated beverages are associated with risk of fractures in women.

SETTING

Population-based sample surveyed by post.

SUBJECTS

A total of 34 703 postmenopausal Iowan women aged 55-69 years were surveyed.

DESIGN

A cohort of women reported alcoholic and caffeinated beverage intake and were followed for 6.5 years for fracture occurrence. Relative risks (RR) and 95% confidence intervals (CI) were computed using Cox proportional hazards regression. Covariates included age, tobacco use, physical activity, body mass index (BMI), waist to hip ratio (WHR), oestrogen use and calcium intake.

RESULTS

At least one fracture was reported by 4378 women (389 upper arm, 288 forearm, 1128 wrist, 275 hip, 416 vertebral and 2920 other fractures). The adjusted RR for highest versus lowest caffeine intake quintiles was 1.09 (95% CI 0.99-1.21) for combined fracture sites. Wrist fractures were associated positively (RR for extreme quintiles 1.37, 95% CI 1.11-1.69) and upper arm fractures were negatively associated (RR 0.67, 95% CI 0.48-0.94) with caffeine intake. The age-adjusted RR of total fractures for highest versus lowest frequency of beer usage was 1.55 (95% CI 1.25-1.92) and for liquor was 1.25 (95% CI 1.03-1.54). No other association was found between any specific fracture site and alcohol intake.

CONCLUSIONS

We found a modest increase in fracture risk associated with highest caffeine intake, varying by site. Alcohol intake was low, but it also showed a weak positive association with fracture risk.

Authors+Show Affiliations

Division of Epidemiology, School of Public Health, Suite 300, University of Minnesota, 1300 South Second Street, Minneapolis, MN 55454-1015, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10979145

Citation

Hansen, S A., et al. "Association of Fractures With Caffeine and Alcohol in Postmenopausal Women: the Iowa Women's Health Study." Public Health Nutrition, vol. 3, no. 3, 2000, pp. 253-61.
Hansen SA, Folsom AR, Kushi LH, et al. Association of fractures with caffeine and alcohol in postmenopausal women: the Iowa Women's Health Study. Public Health Nutr. 2000;3(3):253-61.
Hansen, S. A., Folsom, A. R., Kushi, L. H., & Sellers, T. A. (2000). Association of fractures with caffeine and alcohol in postmenopausal women: the Iowa Women's Health Study. Public Health Nutrition, 3(3), pp. 253-61.
Hansen SA, et al. Association of Fractures With Caffeine and Alcohol in Postmenopausal Women: the Iowa Women's Health Study. Public Health Nutr. 2000;3(3):253-61. PubMed PMID: 10979145.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of fractures with caffeine and alcohol in postmenopausal women: the Iowa Women's Health Study. AU - Hansen,S A, AU - Folsom,A R, AU - Kushi,L H, AU - Sellers,T A, PY - 2000/9/9/pubmed PY - 2001/2/28/medline PY - 2000/9/9/entrez SP - 253 EP - 61 JF - Public health nutrition JO - Public Health Nutr VL - 3 IS - 3 N2 - OBJECTIVE: To assess whether alcoholic and caffeinated beverages are associated with risk of fractures in women. SETTING: Population-based sample surveyed by post. SUBJECTS: A total of 34 703 postmenopausal Iowan women aged 55-69 years were surveyed. DESIGN: A cohort of women reported alcoholic and caffeinated beverage intake and were followed for 6.5 years for fracture occurrence. Relative risks (RR) and 95% confidence intervals (CI) were computed using Cox proportional hazards regression. Covariates included age, tobacco use, physical activity, body mass index (BMI), waist to hip ratio (WHR), oestrogen use and calcium intake. RESULTS: At least one fracture was reported by 4378 women (389 upper arm, 288 forearm, 1128 wrist, 275 hip, 416 vertebral and 2920 other fractures). The adjusted RR for highest versus lowest caffeine intake quintiles was 1.09 (95% CI 0.99-1.21) for combined fracture sites. Wrist fractures were associated positively (RR for extreme quintiles 1.37, 95% CI 1.11-1.69) and upper arm fractures were negatively associated (RR 0.67, 95% CI 0.48-0.94) with caffeine intake. The age-adjusted RR of total fractures for highest versus lowest frequency of beer usage was 1.55 (95% CI 1.25-1.92) and for liquor was 1.25 (95% CI 1.03-1.54). No other association was found between any specific fracture site and alcohol intake. CONCLUSIONS: We found a modest increase in fracture risk associated with highest caffeine intake, varying by site. Alcohol intake was low, but it also showed a weak positive association with fracture risk. SN - 1368-9800 UR - https://www.unboundmedicine.com/medline/citation/10979145/Association_of_fractures_with_caffeine_and_alcohol_in_postmenopausal_women:_the_Iowa_Women's_Health_Study_ L2 - https://www.cambridge.org/core/product/identifier/S136898000000029X/type/journal_article DB - PRIME DP - Unbound Medicine ER -