TY - JOUR T1 - High levels of serum interleukin-10 and tumor necrosis factor-alpha are associated with fatality in fulminant hepatitis. AU - Nagaki,M, AU - Iwai,H, AU - Naiki,T, AU - Ohnishi,H, AU - Muto,Y, AU - Moriwaki,H, Y1 - 2000/08/28/ PY - 2000/04/03/received PY - 2000/07/05/revised PY - 2000/9/9/pubmed PY - 2001/2/28/medline PY - 2000/9/9/entrez SP - 1103 EP - 8 JF - The Journal of infectious diseases JO - J Infect Dis VL - 182 IS - 4 N2 - Serum pro- and anti-inflammatory mediators in patients with acute liver diseases were assessed to clarify the clinical significance of these measurements in relation to disease severity. Concentrations of circulating tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, IL-10, IL-12, and soluble TNF receptors (sTNFR) p55 and p75 were measured at admission in patients with fulminant hepatitis (FH; n=19), severe acute hepatitis (AHS, n=15), or acute hepatitis (AH, n=7). Serum concentrations of TNF-alpha, IL-10, and sTNFR-55 were significantly higher in patients with FH than in those with AHS (P<.05, <.05, and <.01, respectively) or AH (P<.05). Serum IL-10 and TNF-alpha levels were higher in patients who died of FH (n=13) than in FH survivors (n=6; P<.05). The ratios between TNF-alpha and IL-10 and sTNFR-55 or sTNFR-75 were not valuable in predicting mortality and disease severity. However, both proinflammatory cytokine TNF-alpha and anti-inflammatory cytokine IL-10 levels at admission were associated with fatal outcome among patients with FH. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/10979906/High_levels_of_serum_interleukin_10_and_tumor_necrosis_factor_alpha_are_associated_with_fatality_in_fulminant_hepatitis_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/315826 DB - PRIME DP - Unbound Medicine ER -