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Propafenone-induced ataxia: report of three cases.
Am J Med Sci 2000; 320(2):151-3AJ

Abstract

Propafenone is an effective antiarrhythmic drug used widely for the treatment of supraventricular and ventricular arrhythmias. Although it is generally well tolerated, 30 to 45% of patients may experience adverse cardiac effects. In 15 to 20% of patients, adverse effects may involve other organ systems. A wide variety of adverse central nervous system effects have been reported in association with propafenone; dizziness is the most common. Ataxia caused by propafenone has been reported to the pharmaceutical companies and drug monitoring agencies, but has not been well described or emphasized in the medical literature. We describe 3 elderly patients with moderate to severe ataxia that occurred while they were taking propafenone.

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    Authors+Show Affiliations

    Odeh M
    Department of Internal Medicine B, Bnai Zion Medical Center, and Technion Faculty of Medicine, Israel Institute of Technology Haifa.
    Seligmann H
    No affiliation info available
    Oliven A
    No affiliation info available

    MeSH

    AgedAged, 80 and overAmiodaroneAnti-Arrhythmia AgentsAtaxiaAtrial FibrillationBrainFemaleHumansMalePropafenoneTomography, X-Ray Computed

    Pub Type(s)

    Case Reports
    Journal Article

    Language

    eng

    PubMed ID

    10981493

    Citation

    Odeh, M, et al. "Propafenone-induced Ataxia: Report of Three Cases." The American Journal of the Medical Sciences, vol. 320, no. 2, 2000, pp. 151-3.
    Odeh M, Seligmann H, Oliven A. Propafenone-induced ataxia: report of three cases. Am J Med Sci. 2000;320(2):151-3.
    Odeh, M., Seligmann, H., & Oliven, A. (2000). Propafenone-induced ataxia: report of three cases. The American Journal of the Medical Sciences, 320(2), pp. 151-3.
    Odeh M, Seligmann H, Oliven A. Propafenone-induced Ataxia: Report of Three Cases. Am J Med Sci. 2000;320(2):151-3. PubMed PMID: 10981493.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Propafenone-induced ataxia: report of three cases. AU - Odeh,M, AU - Seligmann,H, AU - Oliven,A, PY - 2000/9/12/pubmed PY - 2000/9/23/medline PY - 2000/9/12/entrez SP - 151 EP - 3 JF - The American journal of the medical sciences JO - Am. J. Med. Sci. VL - 320 IS - 2 N2 - Propafenone is an effective antiarrhythmic drug used widely for the treatment of supraventricular and ventricular arrhythmias. Although it is generally well tolerated, 30 to 45% of patients may experience adverse cardiac effects. In 15 to 20% of patients, adverse effects may involve other organ systems. A wide variety of adverse central nervous system effects have been reported in association with propafenone; dizziness is the most common. Ataxia caused by propafenone has been reported to the pharmaceutical companies and drug monitoring agencies, but has not been well described or emphasized in the medical literature. We describe 3 elderly patients with moderate to severe ataxia that occurred while they were taking propafenone. SN - 0002-9629 UR - https://www.unboundmedicine.com/medline/citation/10981493/Propafenone_induced_ataxia:_report_of_three_cases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9629(15)34954-5 DB - PRIME DP - Unbound Medicine ER -