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Vulvar squamous cell carcinoma. Prognostic factors for local recurrence after primary en bloc radical vulvectomy and bilateral groin dissection.
J Reprod Med. 2000 Aug; 45(8):672-8.JR

Abstract

OBJECTIVE

To evaluate clinical prognostic factors for local recurrence of vulvar squamous cell carcinoma after primary surgical treatment.

STUDY DESIGN

Of 104 patients treated for squamous cell carcinoma of the vulva in an 11-year period (1987-1997) at the Portuguese Cancer Institute, we selected for study 56 patients who meet the following criteria: (1) International Federation of Gynecology and Obstetrics (FIGO) stage Ib-IVa, (2) primary treatment of en bloc radical vulvectomy and bilateral groin dissection, and (3) follow-up reports. Files were retrieved for retrospective analysis. Fifteen patients (26.8%) had local recurrence at the fifth year. At the 24th month, 11 patients had local recurrence, and 31 were in follow-up, without recurrence. We evaluated age at initial diagnosis, date of surgical treatment, tumor size, results of tumor macroscopy, histologic differentiation, groin lymph node status, FIGO stage, resection limits, adjuvant radiotherapy, duration of stay, associated vulvar skin disease, date of detection of recurrence, site/sites of recurrence and follow-up status at the 24th month after surgical treatment between the 11 patients with local recurrence and 31 in follow-up without recurrence.

RESULTS

The 11 patients with local recurrence had a significant initial FIGO stage, IVa (P = .049) and a significant association with the number of groin lymph nodes containing metastasis in comparison to the 31 patients without local recurrence. No other statistically compared data were significant.

CONCLUSION

These results suggest that vulvar squamous cell carcinoma local recurrence after a primary surgical procedure is related to poor tumor prognostic factors (number of groin nodes containing tumor metastasis and FIGO stage IVa). On multivariate analysis, the presence of metastasis in two or more groin nodes was a powerful factor related to local recurrence. Postoperative radiotherapy to the vulva for such patients with a high risk of local recurrence is advisable.

Authors+Show Affiliations

Department of Gynecology, Portuguese Cancer Institute, Coimbra, Portugal. jafmoutinh@mail.telepac.ptNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

10986688

Citation

Fonseca-Moutinho, J A., et al. "Vulvar Squamous Cell Carcinoma. Prognostic Factors for Local Recurrence After Primary En Bloc Radical Vulvectomy and Bilateral Groin Dissection." The Journal of Reproductive Medicine, vol. 45, no. 8, 2000, pp. 672-8.
Fonseca-Moutinho JA, Coelho MC, Silva DP. Vulvar squamous cell carcinoma. Prognostic factors for local recurrence after primary en bloc radical vulvectomy and bilateral groin dissection. J Reprod Med. 2000;45(8):672-8.
Fonseca-Moutinho, J. A., Coelho, M. C., & Silva, D. P. (2000). Vulvar squamous cell carcinoma. Prognostic factors for local recurrence after primary en bloc radical vulvectomy and bilateral groin dissection. The Journal of Reproductive Medicine, 45(8), 672-8.
Fonseca-Moutinho JA, Coelho MC, Silva DP. Vulvar Squamous Cell Carcinoma. Prognostic Factors for Local Recurrence After Primary En Bloc Radical Vulvectomy and Bilateral Groin Dissection. J Reprod Med. 2000;45(8):672-8. PubMed PMID: 10986688.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vulvar squamous cell carcinoma. Prognostic factors for local recurrence after primary en bloc radical vulvectomy and bilateral groin dissection. AU - Fonseca-Moutinho,J A, AU - Coelho,M C, AU - Silva,D P, PY - 2000/9/15/pubmed PY - 2001/2/28/medline PY - 2000/9/15/entrez SP - 672 EP - 8 JF - The Journal of reproductive medicine JO - J Reprod Med VL - 45 IS - 8 N2 - OBJECTIVE: To evaluate clinical prognostic factors for local recurrence of vulvar squamous cell carcinoma after primary surgical treatment. STUDY DESIGN: Of 104 patients treated for squamous cell carcinoma of the vulva in an 11-year period (1987-1997) at the Portuguese Cancer Institute, we selected for study 56 patients who meet the following criteria: (1) International Federation of Gynecology and Obstetrics (FIGO) stage Ib-IVa, (2) primary treatment of en bloc radical vulvectomy and bilateral groin dissection, and (3) follow-up reports. Files were retrieved for retrospective analysis. Fifteen patients (26.8%) had local recurrence at the fifth year. At the 24th month, 11 patients had local recurrence, and 31 were in follow-up, without recurrence. We evaluated age at initial diagnosis, date of surgical treatment, tumor size, results of tumor macroscopy, histologic differentiation, groin lymph node status, FIGO stage, resection limits, adjuvant radiotherapy, duration of stay, associated vulvar skin disease, date of detection of recurrence, site/sites of recurrence and follow-up status at the 24th month after surgical treatment between the 11 patients with local recurrence and 31 in follow-up without recurrence. RESULTS: The 11 patients with local recurrence had a significant initial FIGO stage, IVa (P = .049) and a significant association with the number of groin lymph nodes containing metastasis in comparison to the 31 patients without local recurrence. No other statistically compared data were significant. CONCLUSION: These results suggest that vulvar squamous cell carcinoma local recurrence after a primary surgical procedure is related to poor tumor prognostic factors (number of groin nodes containing tumor metastasis and FIGO stage IVa). On multivariate analysis, the presence of metastasis in two or more groin nodes was a powerful factor related to local recurrence. Postoperative radiotherapy to the vulva for such patients with a high risk of local recurrence is advisable. SN - 0024-7758 UR - https://www.unboundmedicine.com/medline/citation/10986688/Vulvar_squamous_cell_carcinoma__Prognostic_factors_for_local_recurrence_after_primary_en_bloc_radical_vulvectomy_and_bilateral_groin_dissection_ L2 - https://www.diseaseinfosearch.org/result/1077 DB - PRIME DP - Unbound Medicine ER -