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Familial clustering of symptoms and disruptive behaviors in multiplex families with attention-deficit/hyperactivity disorder.
J Am Acad Child Adolesc Psychiatry. 2000 Sep; 39(9):1135-43.JA

Abstract

OBJECTIVE

To examine familial clustering of attention-deficit/hyperactivity disorder (ADHD), ADHD subtypes, symptoms, and oppositional behaviors in affected sibling pairs (ASPs) and their parents.

METHOD

One hundred thirty-two ASPs, ranging in age from 5 to 25 years and ascertained through clinic and volunteer referrals, were examined for DSM-IV ADHD subtypes, oppositional defiant disorder (ODD), and conduct disorder (CD) with the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version (K-SADS-PL). Two hundred fifty-six parents in these families were assessed by means of the SADS-Lifetime version, Modified for the Study of Anxiety Disorders, Updated for DSM-IV (SADS-LA-IV), and the Behavioral Disorders supplement of the K-SADS-PL to determine ADHD, ODD, and CD.

RESULTS

Fifty-five percent of families ascertained through an ASP have at least one parent with a lifetime diagnosis of ADHD. The frequency of ADHD in at least one parent was higher in families with at least one affected girl (63%) than in families with only affected boys (45%) (p = .02). There was no evidence that affected siblings or parents within ASP families showed similar patterns of ADHD symptoms, such as ADHD subtype classification. In contrast, CD significantly clustered in ASP families.

CONCLUSIONS

The sex difference in prevalence of ADHD among ASPs is consistent with a model of inheritance in which girls require a greater loading of familial influences to develop ADHD. The lack of familial clustering of ADHD symptoms within ASP families suggests that hyperactive and inattentive symptoms reflect common familial underpinnings and not unique familial effects. In contrast, CD seems to reflect unique familial underpinnings distinct from those underlying ADHD.

Authors+Show Affiliations

Department of Psychiatry, UCLA School of Medicine 90024-1759, USA. ssmalley@mednet.ucla.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10986810

Citation

Smalley, S L., et al. "Familial Clustering of Symptoms and Disruptive Behaviors in Multiplex Families With Attention-deficit/hyperactivity Disorder." Journal of the American Academy of Child and Adolescent Psychiatry, vol. 39, no. 9, 2000, pp. 1135-43.
Smalley SL, McGough JJ, Del'Homme M, et al. Familial clustering of symptoms and disruptive behaviors in multiplex families with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2000;39(9):1135-43.
Smalley, S. L., McGough, J. J., Del'Homme, M., NewDelman, J., Gordon, E., Kim, T., Liu, A., & McCracken, J. T. (2000). Familial clustering of symptoms and disruptive behaviors in multiplex families with attention-deficit/hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 39(9), 1135-43.
Smalley SL, et al. Familial Clustering of Symptoms and Disruptive Behaviors in Multiplex Families With Attention-deficit/hyperactivity Disorder. J Am Acad Child Adolesc Psychiatry. 2000;39(9):1135-43. PubMed PMID: 10986810.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Familial clustering of symptoms and disruptive behaviors in multiplex families with attention-deficit/hyperactivity disorder. AU - Smalley,S L, AU - McGough,J J, AU - Del'Homme,M, AU - NewDelman,J, AU - Gordon,E, AU - Kim,T, AU - Liu,A, AU - McCracken,J T, PY - 2000/9/15/pubmed PY - 2000/10/7/medline PY - 2000/9/15/entrez SP - 1135 EP - 43 JF - Journal of the American Academy of Child and Adolescent Psychiatry JO - J Am Acad Child Adolesc Psychiatry VL - 39 IS - 9 N2 - OBJECTIVE: To examine familial clustering of attention-deficit/hyperactivity disorder (ADHD), ADHD subtypes, symptoms, and oppositional behaviors in affected sibling pairs (ASPs) and their parents. METHOD: One hundred thirty-two ASPs, ranging in age from 5 to 25 years and ascertained through clinic and volunteer referrals, were examined for DSM-IV ADHD subtypes, oppositional defiant disorder (ODD), and conduct disorder (CD) with the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version (K-SADS-PL). Two hundred fifty-six parents in these families were assessed by means of the SADS-Lifetime version, Modified for the Study of Anxiety Disorders, Updated for DSM-IV (SADS-LA-IV), and the Behavioral Disorders supplement of the K-SADS-PL to determine ADHD, ODD, and CD. RESULTS: Fifty-five percent of families ascertained through an ASP have at least one parent with a lifetime diagnosis of ADHD. The frequency of ADHD in at least one parent was higher in families with at least one affected girl (63%) than in families with only affected boys (45%) (p = .02). There was no evidence that affected siblings or parents within ASP families showed similar patterns of ADHD symptoms, such as ADHD subtype classification. In contrast, CD significantly clustered in ASP families. CONCLUSIONS: The sex difference in prevalence of ADHD among ASPs is consistent with a model of inheritance in which girls require a greater loading of familial influences to develop ADHD. The lack of familial clustering of ADHD symptoms within ASP families suggests that hyperactive and inattentive symptoms reflect common familial underpinnings and not unique familial effects. In contrast, CD seems to reflect unique familial underpinnings distinct from those underlying ADHD. SN - 0890-8567 UR - https://www.unboundmedicine.com/medline/citation/10986810/Familial_clustering_of_symptoms_and_disruptive_behaviors_in_multiplex_families_with_attention_deficit/hyperactivity_disorder_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0890-8567(09)66327-9 DB - PRIME DP - Unbound Medicine ER -