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Primary primitive neuroectodermal tumor of the cauda equina.
Hum Pathol. 2000 Aug; 31(8):999-1001.HP

Abstract

Primitive neuroectodermal tumors (PNETs) are aggressive neoplasms composed predominantly of undifferentiated cells that show evidence of neural differentiation. Although their classification has been controversial, PNETs are well recognized primary tumors of both central and peripheral nervous systems. PNETs must be distinguished from other round-cell tumors, including Ewing's sarcoma, lymphoma, rhabdomyosarcoma, and small cell carcinoma. Intraspinal PNETs are rare neoplasms that are usually metastatic in origin. We describe the eighth reported primary PNET of the cauda equina that developed in a 52-year-old man with no significant medical history. The tumor was characterized by Homer-Wright rosettes and immunoreactivity for CD99, glial fibrillary acidic protein, neuron-specific enolase S100, and synaptophysin. The anatomic location of primary intrathecal PNETs is important as those arising in the spinal cord develop in the central nervous system, whereas those arising in the cauda equina develop in the peripheral nervous system. The histogenesis of intrathecal PNETs may be multifactorial.

Authors+Show Affiliations

Department of Laboratory Medicine, Ottawa Hospital, and University of Ottawa, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

10987262

Citation

Isotalo, P A., et al. "Primary Primitive Neuroectodermal Tumor of the Cauda Equina." Human Pathology, vol. 31, no. 8, 2000, pp. 999-1001.
Isotalo PA, Agbi C, Davidson B, et al. Primary primitive neuroectodermal tumor of the cauda equina. Hum Pathol. 2000;31(8):999-1001.
Isotalo, P. A., Agbi, C., Davidson, B., Girard, A., Verma, S., & Robertson, S. J. (2000). Primary primitive neuroectodermal tumor of the cauda equina. Human Pathology, 31(8), 999-1001.
Isotalo PA, et al. Primary Primitive Neuroectodermal Tumor of the Cauda Equina. Hum Pathol. 2000;31(8):999-1001. PubMed PMID: 10987262.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primary primitive neuroectodermal tumor of the cauda equina. AU - Isotalo,P A, AU - Agbi,C, AU - Davidson,B, AU - Girard,A, AU - Verma,S, AU - Robertson,S J, PY - 2000/9/15/pubmed PY - 2000/9/30/medline PY - 2000/9/15/entrez SP - 999 EP - 1001 JF - Human pathology JO - Hum. Pathol. VL - 31 IS - 8 N2 - Primitive neuroectodermal tumors (PNETs) are aggressive neoplasms composed predominantly of undifferentiated cells that show evidence of neural differentiation. Although their classification has been controversial, PNETs are well recognized primary tumors of both central and peripheral nervous systems. PNETs must be distinguished from other round-cell tumors, including Ewing's sarcoma, lymphoma, rhabdomyosarcoma, and small cell carcinoma. Intraspinal PNETs are rare neoplasms that are usually metastatic in origin. We describe the eighth reported primary PNET of the cauda equina that developed in a 52-year-old man with no significant medical history. The tumor was characterized by Homer-Wright rosettes and immunoreactivity for CD99, glial fibrillary acidic protein, neuron-specific enolase S100, and synaptophysin. The anatomic location of primary intrathecal PNETs is important as those arising in the spinal cord develop in the central nervous system, whereas those arising in the cauda equina develop in the peripheral nervous system. The histogenesis of intrathecal PNETs may be multifactorial. SN - 0046-8177 UR - https://www.unboundmedicine.com/medline/citation/10987262/Primary_primitive_neuroectodermal_tumor_of_the_cauda_equina_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0046-8177(00)62733-8 DB - PRIME DP - Unbound Medicine ER -