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Overt and hidden coinfection with hepatitis B and C viruses in chronic liver disease and porphyria cutanea tarda.
Acta Virol. 2000 Feb; 44(1):23-8.AV

Abstract

The aim of this study was to assess the rate of hepatitis B virus (HBV) and hepatitis C virus (HCV) coinfection ("the coinfection") in chronic liver disease (CLD) and to reveal overt and hidden HBV infection in patients with antibodies to HCV (anti-HCV). A total of 209 untreated patients (64 with chronic hepatitis B, 79 with chronic hepatitis C and 66 with porphyria cutanea tarda (PCT)) were screened for serological markers of HBV and HCV infection in serum by third generation enzyme-linked immunosorbent assay (ELISA) methods and for HBV DNA and HCV RNA in serum by polymerase chain reaction (PCR). The rate of the overt coinfection in chronic hepatitis B was very low (2/64, 3%). However, in chronic hepatitis C, the rate of the hidden coinfection with HBV was relatively high (19/79, 24%); these patients had higher alanine transaminase (ALT) and asparagine transaminase (AST) levels in serum and a more advanced liver disease. In PCT patients, the rates of HBV and HCV infections were the same, 21% (14/66). In the PCT patients infected with HBV or HCV, the rate of the coinfection was 33% (7/21). The PCT patients with the coinfection had a high serum ALT level and the worst histological picture in the liver. The hidden HBV infection was more frequent than the overt one. The possibility of the overt or hidden coinfection in CLD renders a detailed analysis of all serum samples for both viruses mandatory. Vaccination against HBV infection should be offered to anti-HCV-positive individuals as well as to PCT patients not showing antibodies to HBV (anti-HBV).

Authors+Show Affiliations

Department of Internal Medicine I, Third Faculty of Medicine, Charles University, Prague, Czech Republic. jan.kyncl@szu.czNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

10989688

Citation

Stránský, J, et al. "Overt and Hidden Coinfection With Hepatitis B and C Viruses in Chronic Liver Disease and Porphyria Cutanea Tarda." Acta Virologica, vol. 44, no. 1, 2000, pp. 23-8.
Stránský J, Malina L, Cieslarová B, et al. Overt and hidden coinfection with hepatitis B and C viruses in chronic liver disease and porphyria cutanea tarda. Acta Virol. 2000;44(1):23-8.
Stránský, J., Malina, L., Cieslarová, B., Stríteský, J., Půtová, I., & Horák, J. (2000). Overt and hidden coinfection with hepatitis B and C viruses in chronic liver disease and porphyria cutanea tarda. Acta Virologica, 44(1), 23-8.
Stránský J, et al. Overt and Hidden Coinfection With Hepatitis B and C Viruses in Chronic Liver Disease and Porphyria Cutanea Tarda. Acta Virol. 2000;44(1):23-8. PubMed PMID: 10989688.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Overt and hidden coinfection with hepatitis B and C viruses in chronic liver disease and porphyria cutanea tarda. AU - Stránský,J, AU - Malina,L, AU - Cieslarová,B, AU - Stríteský,J, AU - Půtová,I, AU - Horák,J, PY - 2000/9/16/pubmed PY - 2001/2/28/medline PY - 2000/9/16/entrez SP - 23 EP - 8 JF - Acta virologica JO - Acta Virol VL - 44 IS - 1 N2 - The aim of this study was to assess the rate of hepatitis B virus (HBV) and hepatitis C virus (HCV) coinfection ("the coinfection") in chronic liver disease (CLD) and to reveal overt and hidden HBV infection in patients with antibodies to HCV (anti-HCV). A total of 209 untreated patients (64 with chronic hepatitis B, 79 with chronic hepatitis C and 66 with porphyria cutanea tarda (PCT)) were screened for serological markers of HBV and HCV infection in serum by third generation enzyme-linked immunosorbent assay (ELISA) methods and for HBV DNA and HCV RNA in serum by polymerase chain reaction (PCR). The rate of the overt coinfection in chronic hepatitis B was very low (2/64, 3%). However, in chronic hepatitis C, the rate of the hidden coinfection with HBV was relatively high (19/79, 24%); these patients had higher alanine transaminase (ALT) and asparagine transaminase (AST) levels in serum and a more advanced liver disease. In PCT patients, the rates of HBV and HCV infections were the same, 21% (14/66). In the PCT patients infected with HBV or HCV, the rate of the coinfection was 33% (7/21). The PCT patients with the coinfection had a high serum ALT level and the worst histological picture in the liver. The hidden HBV infection was more frequent than the overt one. The possibility of the overt or hidden coinfection in CLD renders a detailed analysis of all serum samples for both viruses mandatory. Vaccination against HBV infection should be offered to anti-HCV-positive individuals as well as to PCT patients not showing antibodies to HBV (anti-HBV). SN - 0001-723X UR - https://www.unboundmedicine.com/medline/citation/10989688/Overt_and_hidden_coinfection_with_hepatitis_B_and_C_viruses_in_chronic_liver_disease_and_porphyria_cutanea_tarda_ L2 - http://www.diseaseinfosearch.org/result/5879 DB - PRIME DP - Unbound Medicine ER -