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[Consumption of antihypertensive agents in obese patients: a cross-sectional study in a sample of 3,291 wage-earners in the Toulous region].
Arch Mal Coeur Vaiss 2000; 93(8):925-9AM

Abstract

A cross-sectional study in a sample of 3,291 healthy workers was performed in May 1997 to assess the prevalence of obesity (BMI > or = 30 kg/m2) in a working population, and to compare prescription of antihypertensive drugs in obese and non obese subjects. Obesity was found in 7.4% (245) subjects and morbid obesity concerned 0.4% of the total sample (mean age 37.6 +/- 9.7 [SD] years, 52.4% of males). Risk of obesity was significantly associated with age, male sex, professional classes (higher in blue collars workers, lower in senior executive), business travels, atypical schedules, professional and private difficulties. Albeit the prevalence of drug users (49.7%) was similar whatever the BMI, obese subjects used a higher number of drugs than non obese (2.0 +/- 1.2 versus 1.6 +/- 0.9, p < 0.001). Risk of consumption of cardiovascular drugs was higher in obese than in non obese subjects (OR 2.9, 95% CI [2.2-4.1]). After adjustment on confounding factors, obesity increased specific drug use such as angiotensin converting enzyme inhibitors (OR 3.3, 95% CI [1.7-6.4]), beta-blocking agents (OR 2.83, 95% CI [1.01-8.01]), calcium channel blockers (OR 2.44, 95% CI [1.06-5.63]) or diuretics only in women (OR 5.7, 95% CI [2.1-16.3]). Prescribed antihypertensive drugs were different in obese (beta-blockers = angiotensin converting enzyme inhibitors > diuretics > calcium channels blockers) and non obese (angiotensin converting enzyme inhibitors > calcium channel blockers > diuretics > beta-blockers) subjects.

Authors+Show Affiliations

Laboratoire de pharmacologie médicale et clinique, INSERM U 317, centre Midi-Pyrénées de pharmacovigilance, de pharmacoépidémiologie et d'informations sur le médicament, faculté de médecine, Toulouse.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

fre

PubMed ID

10989731

Citation

Lapeyre-Mestre, M, et al. "[Consumption of Antihypertensive Agents in Obese Patients: a Cross-sectional Study in a Sample of 3,291 Wage-earners in the Toulous Region]." Archives Des Maladies Du Coeur Et Des Vaisseaux, vol. 93, no. 8, 2000, pp. 925-9.
Lapeyre-Mestre M, Sulem P, Chastan E, et al. [Consumption of antihypertensive agents in obese patients: a cross-sectional study in a sample of 3,291 wage-earners in the Toulous region]. Arch Mal Coeur Vaiss. 2000;93(8):925-9.
Lapeyre-Mestre, M., Sulem, P., Chastan, E., Niezborala, M., Briant, D., Jansou, P., ... Montastruc, J. L. (2000). [Consumption of antihypertensive agents in obese patients: a cross-sectional study in a sample of 3,291 wage-earners in the Toulous region]. Archives Des Maladies Du Coeur Et Des Vaisseaux, 93(8), pp. 925-9.
Lapeyre-Mestre M, et al. [Consumption of Antihypertensive Agents in Obese Patients: a Cross-sectional Study in a Sample of 3,291 Wage-earners in the Toulous Region]. Arch Mal Coeur Vaiss. 2000;93(8):925-9. PubMed PMID: 10989731.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Consumption of antihypertensive agents in obese patients: a cross-sectional study in a sample of 3,291 wage-earners in the Toulous region]. AU - Lapeyre-Mestre,M, AU - Sulem,P, AU - Chastan,E, AU - Niezborala,M, AU - Briant,D, AU - Jansou,P, AU - Sanguignol,F, AU - Montastruc,J L, PY - 2000/9/16/pubmed PY - 2000/10/21/medline PY - 2000/9/16/entrez SP - 925 EP - 9 JF - Archives des maladies du coeur et des vaisseaux JO - Arch Mal Coeur Vaiss VL - 93 IS - 8 N2 - A cross-sectional study in a sample of 3,291 healthy workers was performed in May 1997 to assess the prevalence of obesity (BMI > or = 30 kg/m2) in a working population, and to compare prescription of antihypertensive drugs in obese and non obese subjects. Obesity was found in 7.4% (245) subjects and morbid obesity concerned 0.4% of the total sample (mean age 37.6 +/- 9.7 [SD] years, 52.4% of males). Risk of obesity was significantly associated with age, male sex, professional classes (higher in blue collars workers, lower in senior executive), business travels, atypical schedules, professional and private difficulties. Albeit the prevalence of drug users (49.7%) was similar whatever the BMI, obese subjects used a higher number of drugs than non obese (2.0 +/- 1.2 versus 1.6 +/- 0.9, p < 0.001). Risk of consumption of cardiovascular drugs was higher in obese than in non obese subjects (OR 2.9, 95% CI [2.2-4.1]). After adjustment on confounding factors, obesity increased specific drug use such as angiotensin converting enzyme inhibitors (OR 3.3, 95% CI [1.7-6.4]), beta-blocking agents (OR 2.83, 95% CI [1.01-8.01]), calcium channel blockers (OR 2.44, 95% CI [1.06-5.63]) or diuretics only in women (OR 5.7, 95% CI [2.1-16.3]). Prescribed antihypertensive drugs were different in obese (beta-blockers = angiotensin converting enzyme inhibitors > diuretics > calcium channels blockers) and non obese (angiotensin converting enzyme inhibitors > calcium channel blockers > diuretics > beta-blockers) subjects. SN - 0003-9683 UR - https://www.unboundmedicine.com/medline/citation/10989731/[Consumption_of_antihypertensive_agents_in_obese_patients:_a_cross_sectional_study_in_a_sample_of_3291_wage_earners_in_the_Toulous_region]_ L2 - https://medlineplus.gov/obesity.html DB - PRIME DP - Unbound Medicine ER -