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Magnetic stimulation of the sacral roots for the treatment of stress incontinence: an investigational study and placebo controlled trial.
J Urol. 2000 Oct; 164(4):1277-9.JU

Abstract

PURPOSE

We designed an investigational study and placebo controlled trial to evaluate the potential efficacy of magnetic stimulation of the sacral roots for the treatment of stress incontinence.

MATERIALS AND METHODS

A total of 75 patients with stress incontinence were studied. A 15 Hz. repetitive magnetic stimulation of the sacral roots with 50% intensity output and duration of 5 seconds per minute was applied for 30 minutes. Urodynamic investigations under magnetic stimulation were performed in 13 patients to evaluate acute effects to lower urinary tract function. There were 62 women (mean age 58 years) enrolled in a placebo controlled study to investigate the short-term efficacy of magnetic stimulation. The number of leaks for 3 days, amount of urine loss on a pad test and quality of life score were evaluated before and 1 week after stimulation.

RESULTS

The urodynamic investigations revealed an apparent elevation of urethral closure pressure induced by stimulation (mean 8.2 +/- 3.0 cm H2O, p = 0.0000004) and a significant increase in bladder capacity after stimulation (mean 40.0 +/- 51.0 ml., p = 0.0152). In the placebo controlled study the number of leaks and amount of urine loss on a pad test significantly decreased more in the active than in the sham stimulation group (p = 0.0023 and 0.0377, respectively). The quality of life score significantly improved in the active stimulation group (p = 0.0006) in contrast to no significant improvement in the sham stimulation group. The improvement rate in the active stimulation group was 74%, which was significantly higher than the 32% in the sham stimulation group (p = 0.0009). No adverse effects were noted in any patients.

CONCLUSIONS

These results suggest that magnetic stimulation of the sacral roots may be useful for the treatment of stress incontinence. Further studies are needed to evaluate the long-term efficacy of this potential treatment.

Authors+Show Affiliations

Department of Urology, Sanraku Hospital, and Department of Neurology and Urology, Institute of Medical Electronics, Faculty of Medicine, University of Tokyo, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10992380

Citation

Fujishiro, T, et al. "Magnetic Stimulation of the Sacral Roots for the Treatment of Stress Incontinence: an Investigational Study and Placebo Controlled Trial." The Journal of Urology, vol. 164, no. 4, 2000, pp. 1277-9.
Fujishiro T, Enomoto H, Ugawa Y, et al. Magnetic stimulation of the sacral roots for the treatment of stress incontinence: an investigational study and placebo controlled trial. J Urol. 2000;164(4):1277-9.
Fujishiro, T., Enomoto, H., Ugawa, Y., Takahashi, S., Ueno, S., & Kitamura, T. (2000). Magnetic stimulation of the sacral roots for the treatment of stress incontinence: an investigational study and placebo controlled trial. The Journal of Urology, 164(4), 1277-9.
Fujishiro T, et al. Magnetic Stimulation of the Sacral Roots for the Treatment of Stress Incontinence: an Investigational Study and Placebo Controlled Trial. J Urol. 2000;164(4):1277-9. PubMed PMID: 10992380.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Magnetic stimulation of the sacral roots for the treatment of stress incontinence: an investigational study and placebo controlled trial. AU - Fujishiro,T, AU - Enomoto,H, AU - Ugawa,Y, AU - Takahashi,S, AU - Ueno,S, AU - Kitamura,T, PY - 2000/9/19/pubmed PY - 2000/10/7/medline PY - 2000/9/19/entrez SP - 1277 EP - 9 JF - The Journal of urology JO - J Urol VL - 164 IS - 4 N2 - PURPOSE: We designed an investigational study and placebo controlled trial to evaluate the potential efficacy of magnetic stimulation of the sacral roots for the treatment of stress incontinence. MATERIALS AND METHODS: A total of 75 patients with stress incontinence were studied. A 15 Hz. repetitive magnetic stimulation of the sacral roots with 50% intensity output and duration of 5 seconds per minute was applied for 30 minutes. Urodynamic investigations under magnetic stimulation were performed in 13 patients to evaluate acute effects to lower urinary tract function. There were 62 women (mean age 58 years) enrolled in a placebo controlled study to investigate the short-term efficacy of magnetic stimulation. The number of leaks for 3 days, amount of urine loss on a pad test and quality of life score were evaluated before and 1 week after stimulation. RESULTS: The urodynamic investigations revealed an apparent elevation of urethral closure pressure induced by stimulation (mean 8.2 +/- 3.0 cm H2O, p = 0.0000004) and a significant increase in bladder capacity after stimulation (mean 40.0 +/- 51.0 ml., p = 0.0152). In the placebo controlled study the number of leaks and amount of urine loss on a pad test significantly decreased more in the active than in the sham stimulation group (p = 0.0023 and 0.0377, respectively). The quality of life score significantly improved in the active stimulation group (p = 0.0006) in contrast to no significant improvement in the sham stimulation group. The improvement rate in the active stimulation group was 74%, which was significantly higher than the 32% in the sham stimulation group (p = 0.0009). No adverse effects were noted in any patients. CONCLUSIONS: These results suggest that magnetic stimulation of the sacral roots may be useful for the treatment of stress incontinence. Further studies are needed to evaluate the long-term efficacy of this potential treatment. SN - 0022-5347 UR - https://www.unboundmedicine.com/medline/citation/10992380/Magnetic_stimulation_of_the_sacral_roots_for_the_treatment_of_stress_incontinence:_an_investigational_study_and_placebo_controlled_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-5347(05)67155-8 DB - PRIME DP - Unbound Medicine ER -