Prime

Type your tag names separated by a space and hit enter

Serum S100 protein as a marker of cerebral damage during cardiac surgery.

Abstract

The identification of a serum marker to assist in the diagnosis of cerebral injury after cardiac surgery is potentially useful. S100 protein is an early marker of cerebral damage. It is released after cardiac surgery performed under cardiopulmonary bypass (CPB). Its level is correlated with the duration of CPB, deep circulatory arrest and aortic cross-clamping. Increased levels of S100 protein are correlated with the age of the patient and the number of microemboli, especially during aortic cannulation. Perioperative cerebral complications such as stroke, delayed awakening and confusion are associated with increased levels of S100 protein directly after bypass and from 15 to 48 h after it. In addition, increased levels of S100 protein are related to neuropsychological dysfunction after cardiac surgery. S100 protein has early and late release patterns after CPB; the early pattern may be due to sub-clinical brain injury. The late release pattern may be due to perioperative cerebral complications. Patients undergoing intracardiac operations combined with coronary artery bypass surgery are more susceptible to brain injury and have higher levels of S100 after CPB. Furthermore, adults and children undergoing deep circulatory arrest are more susceptible to brain injury, in terms of higher S100 protein release after CPB. Serum S100 protein levels are reduced after using arterial line filtration and covalent-bonded heparin to coat the inner surface of the CPB circuit.

Links

  • Aggregator Full Text
  • Authors+Show Affiliations

    ,

    Department of Anaesthetics and Intensive Care Medicine, University of Wales College of Medicine, Cardiff, UK.

    ,

    Source

    British journal of anaesthesia 85:2 2000 Aug pg 287-98

    MeSH

    Biomarkers
    Brain Injuries
    Cardiac Surgical Procedures
    Cardiopulmonary Bypass
    Humans
    Prognosis
    S100 Proteins

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    10992840

    Citation

    TY - JOUR T1 - Serum S100 protein as a marker of cerebral damage during cardiac surgery. AU - Ali,M S, AU - Harmer,M, AU - Vaughan,R, PY - 2000/9/19/pubmed PY - 2000/9/23/medline PY - 2000/9/19/entrez SP - 287 EP - 98 JF - British journal of anaesthesia JO - Br J Anaesth VL - 85 IS - 2 N2 - The identification of a serum marker to assist in the diagnosis of cerebral injury after cardiac surgery is potentially useful. S100 protein is an early marker of cerebral damage. It is released after cardiac surgery performed under cardiopulmonary bypass (CPB). Its level is correlated with the duration of CPB, deep circulatory arrest and aortic cross-clamping. Increased levels of S100 protein are correlated with the age of the patient and the number of microemboli, especially during aortic cannulation. Perioperative cerebral complications such as stroke, delayed awakening and confusion are associated with increased levels of S100 protein directly after bypass and from 15 to 48 h after it. In addition, increased levels of S100 protein are related to neuropsychological dysfunction after cardiac surgery. S100 protein has early and late release patterns after CPB; the early pattern may be due to sub-clinical brain injury. The late release pattern may be due to perioperative cerebral complications. Patients undergoing intracardiac operations combined with coronary artery bypass surgery are more susceptible to brain injury and have higher levels of S100 after CPB. Furthermore, adults and children undergoing deep circulatory arrest are more susceptible to brain injury, in terms of higher S100 protein release after CPB. Serum S100 protein levels are reduced after using arterial line filtration and covalent-bonded heparin to coat the inner surface of the CPB circuit. SN - 0007-0912 UR - https://www.unboundmedicine.com/medline/citation/10992840/Serum_S100_protein_as_a_marker_of_cerebral_damage_during_cardiac_surgery_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=10992840.ui ER -