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Phytochemical flavones isolated from Scutellaria barbata and antibacterial activity against methicillin-resistant Staphylococcus aureus.
J Ethnopharmacol. 2000 Oct; 72(3):483-8.JE

Abstract

A crude extract prepared from Scutellaria barbata D. Don (Lamiaceae) was analyzed in the effort to discover antibacterial compounds against high-level strains of methicillin-resistant Staphylococcus aureus (MRSA). Apigenin and luteolin were isolated from the plant as active constituents against the bacteria. These flavonoid congeners were selectively toxic to S. aureus, including the MRSA and methicillin-sensitive S. aureus strains.

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Authors+Show Affiliations

Sato Y
Laboratory of Microbial Chemistry, Faculty of Pharmaceutical Sciences, University of Tokushima, Sho-machi 1-78, 770-8505, Tokushima, Japan.
Suzaki S
No affiliation info available
Nishikawa T
No affiliation info available
Kihara M
No affiliation info available
Shibata H
No affiliation info available
Higuti T
No affiliation info available

MeSH

Anti-Bacterial AgentsBase SequenceDNA PrimersFlavonoidsLamiaceaeMethicillin ResistanceMicrobial Sensitivity TestsStaphylococcus aureus

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10996290

Citation

Sato, Y, et al. "Phytochemical Flavones Isolated From Scutellaria Barbata and Antibacterial Activity Against Methicillin-resistant Staphylococcus Aureus." Journal of Ethnopharmacology, vol. 72, no. 3, 2000, pp. 483-8.
Sato Y, Suzaki S, Nishikawa T, et al. Phytochemical flavones isolated from Scutellaria barbata and antibacterial activity against methicillin-resistant Staphylococcus aureus. J Ethnopharmacol. 2000;72(3):483-8.
Sato, Y., Suzaki, S., Nishikawa, T., Kihara, M., Shibata, H., & Higuti, T. (2000). Phytochemical flavones isolated from Scutellaria barbata and antibacterial activity against methicillin-resistant Staphylococcus aureus. Journal of Ethnopharmacology, 72(3), 483-8.
Sato Y, et al. Phytochemical Flavones Isolated From Scutellaria Barbata and Antibacterial Activity Against Methicillin-resistant Staphylococcus Aureus. J Ethnopharmacol. 2000;72(3):483-8. PubMed PMID: 10996290.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phytochemical flavones isolated from Scutellaria barbata and antibacterial activity against methicillin-resistant Staphylococcus aureus. AU - Sato,Y, AU - Suzaki,S, AU - Nishikawa,T, AU - Kihara,M, AU - Shibata,H, AU - Higuti,T, PY - 2000/9/21/pubmed PY - 2001/3/3/medline PY - 2000/9/21/entrez SP - 483 EP - 8 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 72 IS - 3 N2 - A crude extract prepared from Scutellaria barbata D. Don (Lamiaceae) was analyzed in the effort to discover antibacterial compounds against high-level strains of methicillin-resistant Staphylococcus aureus (MRSA). Apigenin and luteolin were isolated from the plant as active constituents against the bacteria. These flavonoid congeners were selectively toxic to S. aureus, including the MRSA and methicillin-sensitive S. aureus strains. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/10996290/Phytochemical_flavones_isolated_from_Scutellaria_barbata_and_antibacterial_activity_against_methicillin_resistant_Staphylococcus_aureus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378874100002658 DB - PRIME DP - Unbound Medicine ER -