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Telomerase activity and telomere length in benign and malignant human thyroid tissues.
Cancer Lett. 2000 Oct 31; 159(2):175-81.CL

Abstract

Several studies have demonstrated that telomerase is activated and telomere length is altered in various types of tumors. In this study, we investigated telomerase activities and telomere length in 21 thyroid tumors. Telomerase activity was detected in 11 of 12 thyroid cancers and three of nine follicular adenomas. The mean telomere lengths in the cancers tissue and follicular adenomas were lower than in the respective background tissues, the differences being significant (P=0.0055 and P<0.006), respectively. Our findings suggest that change in telomerase activity and telomere length may be important for development of thyroid tumors.

Authors+Show Affiliations

Department of Surgery, Endocrine and Metabolic Unit, The University of Tokyo, 3-28-6 Mejirodai Bunkyo-ku, Tokyo 112-8688, Japan. kanmori-dis@h.u-tokyo.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10996729

Citation

Kammori, M, et al. "Telomerase Activity and Telomere Length in Benign and Malignant Human Thyroid Tissues." Cancer Letters, vol. 159, no. 2, 2000, pp. 175-81.
Kammori M, Takubo K, Nakamura K, et al. Telomerase activity and telomere length in benign and malignant human thyroid tissues. Cancer Lett. 2000;159(2):175-81.
Kammori, M., Takubo, K., Nakamura, K., Furugouri, E., Endo, H., Kanauchi, H., Mimura, Y., & Kaminishi, M. (2000). Telomerase activity and telomere length in benign and malignant human thyroid tissues. Cancer Letters, 159(2), 175-81.
Kammori M, et al. Telomerase Activity and Telomere Length in Benign and Malignant Human Thyroid Tissues. Cancer Lett. 2000 Oct 31;159(2):175-81. PubMed PMID: 10996729.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Telomerase activity and telomere length in benign and malignant human thyroid tissues. AU - Kammori,M, AU - Takubo,K, AU - Nakamura,K, AU - Furugouri,E, AU - Endo,H, AU - Kanauchi,H, AU - Mimura,Y, AU - Kaminishi,M, PY - 2000/9/21/pubmed PY - 2001/2/28/medline PY - 2000/9/21/entrez SP - 175 EP - 81 JF - Cancer letters JO - Cancer Lett VL - 159 IS - 2 N2 - Several studies have demonstrated that telomerase is activated and telomere length is altered in various types of tumors. In this study, we investigated telomerase activities and telomere length in 21 thyroid tumors. Telomerase activity was detected in 11 of 12 thyroid cancers and three of nine follicular adenomas. The mean telomere lengths in the cancers tissue and follicular adenomas were lower than in the respective background tissues, the differences being significant (P=0.0055 and P<0.006), respectively. Our findings suggest that change in telomerase activity and telomere length may be important for development of thyroid tumors. SN - 0304-3835 UR - https://www.unboundmedicine.com/medline/citation/10996729/Telomerase_activity_and_telomere_length_in_benign_and_malignant_human_thyroid_tissues_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304383500005474 DB - PRIME DP - Unbound Medicine ER -