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Ascorbate levels in red blood cells and urine in patients with sickle cell anemia.
Am J Hematol 2000; 65(2):174-5AJ

Abstract

Ascorbic acid can be important in sickle cell anemia (SCA) because significant oxidative stress occurs in the disease. Ascorbate could contribute to reduction of the increased oxygen free radicals generated in sickle red blood cells (SRBC) and to the recycling of vitamin E in the cells, while renal loss could contribute to the low plasma levels. Evaluation of red blood cell (RBC) and urine ascorbate in SCA has not been reported. Results showed (1) ascorbate levels in SRBC were similar to those in normals; (2) urine ascorbate excretion was increased in 36% of patients; (3) plasma levels of ascorbate were decreased.

CONCLUSIONS

(1) Ascorbate is present in SRBC, most likely due to ascorbate recycling, despite increased free-radical generation. (2) The increase in renal excretion may contribute to the low plasma levels of ascorbate. (3) The presence of ample ascorbate in SRBC and decreased plasma ascorbate suggests that ascorbate movement across the SRBC membrane may differ from normal RBC.

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  • Publisher Full Text

    • Authors+Show Affiliations

    Westerman MP
    Department of Medicine, Mount Sinai Hospital Medical Center, Chicago, Illinois 60608, USA. wesm@sinai.org
    Zhang Y
    No affiliation info available
    McConnell JP
    No affiliation info available
    Chezick PA
    No affiliation info available
    Neelam R
    No affiliation info available
    Freels S
    No affiliation info available
    Feldman LS
    No affiliation info available
    Allen S
    No affiliation info available
    Baridi R
    No affiliation info available
    Feldman LE
    No affiliation info available
    Fung LW
    No affiliation info available

    MeSH

    AdultAnemia, Sickle CellAscorbic AcidErythrocytesHumansMatched-Pair AnalysisMiddle AgedOsmolar ConcentrationSodium

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    10996838

    Citation

    Westerman, M P., et al. "Ascorbate Levels in Red Blood Cells and Urine in Patients With Sickle Cell Anemia." American Journal of Hematology, vol. 65, no. 2, 2000, pp. 174-5.
    Westerman MP, Zhang Y, McConnell JP, et al. Ascorbate levels in red blood cells and urine in patients with sickle cell anemia. Am J Hematol. 2000;65(2):174-5.
    Westerman, M. P., Zhang, Y., McConnell, J. P., Chezick, P. A., Neelam, R., Freels, S., ... Fung, L. W. (2000). Ascorbate levels in red blood cells and urine in patients with sickle cell anemia. American Journal of Hematology, 65(2), pp. 174-5.
    Westerman MP, et al. Ascorbate Levels in Red Blood Cells and Urine in Patients With Sickle Cell Anemia. Am J Hematol. 2000;65(2):174-5. PubMed PMID: 10996838.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Ascorbate levels in red blood cells and urine in patients with sickle cell anemia. AU - Westerman,M P, AU - Zhang,Y, AU - McConnell,J P, AU - Chezick,P A, AU - Neelam,R, AU - Freels,S, AU - Feldman,L S, AU - Allen,S, AU - Baridi,R, AU - Feldman,L E, AU - Fung,L W, PY - 2000/9/21/pubmed PY - 2001/2/28/medline PY - 2000/9/21/entrez SP - 174 EP - 5 JF - American journal of hematology JO - Am. J. Hematol. VL - 65 IS - 2 N2 - UNLABELLED: Ascorbic acid can be important in sickle cell anemia (SCA) because significant oxidative stress occurs in the disease. Ascorbate could contribute to reduction of the increased oxygen free radicals generated in sickle red blood cells (SRBC) and to the recycling of vitamin E in the cells, while renal loss could contribute to the low plasma levels. Evaluation of red blood cell (RBC) and urine ascorbate in SCA has not been reported. Results showed (1) ascorbate levels in SRBC were similar to those in normals; (2) urine ascorbate excretion was increased in 36% of patients; (3) plasma levels of ascorbate were decreased. CONCLUSIONS: (1) Ascorbate is present in SRBC, most likely due to ascorbate recycling, despite increased free-radical generation. (2) The increase in renal excretion may contribute to the low plasma levels of ascorbate. (3) The presence of ample ascorbate in SRBC and decreased plasma ascorbate suggests that ascorbate movement across the SRBC membrane may differ from normal RBC. SN - 0361-8609 UR - https://www.unboundmedicine.com/medline/citation/10996838/full_citation L2 - https://doi.org/10.1002/1096-8652(200010)65:2<174::aid-ajh15>3.0.co;2-t DB - PRIME DP - Unbound Medicine ER -