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Ascorbate levels in red blood cells and urine in patients with sickle cell anemia.

Abstract

Ascorbic acid can be important in sickle cell anemia (SCA) because significant oxidative stress occurs in the disease. Ascorbate could contribute to reduction of the increased oxygen free radicals generated in sickle red blood cells (SRBC) and to the recycling of vitamin E in the cells, while renal loss could contribute to the low plasma levels. Evaluation of red blood cell (RBC) and urine ascorbate in SCA has not been reported. Results showed (1) ascorbate levels in SRBC were similar to those in normals; (2) urine ascorbate excretion was increased in 36% of patients; (3) plasma levels of ascorbate were decreased.

Conclusions:

(1) Ascorbate is present in SRBC, most likely due to ascorbate recycling, despite increased free-radical generation. (2) The increase in renal excretion may contribute to the low plasma levels of ascorbate. (3) The presence of ample ascorbate in SRBC and decreased plasma ascorbate suggests that ascorbate movement across the SRBC membrane may differ from normal RBC.

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  • Authors

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    Source

    American journal of hematology 65:2 2000 Oct pg 174-5

    MeSH

    Adult
    Anemia, Sickle Cell
    Ascorbic Acid
    Erythrocytes
    Humans
    Matched-Pair Analysis
    Middle Aged
    Osmolar Concentration
    Sodium

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    10996838

    Citation

    TY - JOUR T1 - Ascorbate levels in red blood cells and urine in patients with sickle cell anemia. AU - Westerman,M P, AU - Zhang,Y, AU - McConnell,J P, AU - Chezick,P A, AU - Neelam,R, AU - Freels,S, AU - Feldman,L S, AU - Allen,S, AU - Baridi,R, AU - Feldman,L E, AU - Fung,L W, PY - 2000/9/21/pubmed PY - 2001/2/28/medline PY - 2000/9/21/entrez SP - 174 EP - 5 JF - American journal of hematology JO - Am. J. Hematol. VL - 65 IS - 2 N2 - Ascorbic acid can be important in sickle cell anemia (SCA) because significant oxidative stress occurs in the disease. Ascorbate could contribute to reduction of the increased oxygen free radicals generated in sickle red blood cells (SRBC) and to the recycling of vitamin E in the cells, while renal loss could contribute to the low plasma levels. Evaluation of red blood cell (RBC) and urine ascorbate in SCA has not been reported. Results showed (1) ascorbate levels in SRBC were similar to those in normals; (2) urine ascorbate excretion was increased in 36% of patients; (3) plasma levels of ascorbate were decreased. Conclusions: (1) Ascorbate is present in SRBC, most likely due to ascorbate recycling, despite increased free-radical generation. (2) The increase in renal excretion may contribute to the low plasma levels of ascorbate. (3) The presence of ample ascorbate in SRBC and decreased plasma ascorbate suggests that ascorbate movement across the SRBC membrane may differ from normal RBC. SN - 0361-8609 UR - https://www.unboundmedicine.com/medline/citation/10996838/full_citation L2 - http://dx.doi.org/10.1002/1096-8652(200010)65:2<174::AID-AJH15>3.0.CO;2-T ER -