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Ascorbate levels in red blood cells and urine in patients with sickle cell anemia.

Abstract

Ascorbic acid can be important in sickle cell anemia (SCA) because significant oxidative stress occurs in the disease. Ascorbate could contribute to reduction of the increased oxygen free radicals generated in sickle red blood cells (SRBC) and to the recycling of vitamin E in the cells, while renal loss could contribute to the low plasma levels. Evaluation of red blood cell (RBC) and urine ascorbate in SCA has not been reported. Results showed (1) ascorbate levels in SRBC were similar to those in normals; (2) urine ascorbate excretion was increased in 36% of patients; (3) plasma levels of ascorbate were decreased.

CONCLUSIONS

(1) Ascorbate is present in SRBC, most likely due to ascorbate recycling, despite increased free-radical generation. (2) The increase in renal excretion may contribute to the low plasma levels of ascorbate. (3) The presence of ample ascorbate in SRBC and decreased plasma ascorbate suggests that ascorbate movement across the SRBC membrane may differ from normal RBC.

Authors+Show Affiliations

,

Department of Medicine, Mount Sinai Hospital Medical Center, Chicago, Illinois 60608, USA. wesm@sinai.org

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Source

American journal of hematology 65:2 2000 Oct pg 174-5

MeSH

Adult
Anemia, Sickle Cell
Ascorbic Acid
Erythrocytes
Humans
Matched-Pair Analysis
Middle Aged
Osmolar Concentration
Sodium

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10996838

Citation

Westerman, M P., et al. "Ascorbate Levels in Red Blood Cells and Urine in Patients With Sickle Cell Anemia." American Journal of Hematology, vol. 65, no. 2, 2000, pp. 174-5.
Westerman MP, Zhang Y, McConnell JP, et al. Ascorbate levels in red blood cells and urine in patients with sickle cell anemia. Am J Hematol. 2000;65(2):174-5.
Westerman, M. P., Zhang, Y., McConnell, J. P., Chezick, P. A., Neelam, R., Freels, S., ... Fung, L. W. (2000). Ascorbate levels in red blood cells and urine in patients with sickle cell anemia. American Journal of Hematology, 65(2), pp. 174-5.
Westerman MP, et al. Ascorbate Levels in Red Blood Cells and Urine in Patients With Sickle Cell Anemia. Am J Hematol. 2000;65(2):174-5. PubMed PMID: 10996838.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ascorbate levels in red blood cells and urine in patients with sickle cell anemia. AU - Westerman,M P, AU - Zhang,Y, AU - McConnell,J P, AU - Chezick,P A, AU - Neelam,R, AU - Freels,S, AU - Feldman,L S, AU - Allen,S, AU - Baridi,R, AU - Feldman,L E, AU - Fung,L W, PY - 2000/9/21/pubmed PY - 2001/2/28/medline PY - 2000/9/21/entrez SP - 174 EP - 5 JF - American journal of hematology JO - Am. J. Hematol. VL - 65 IS - 2 N2 - UNLABELLED: Ascorbic acid can be important in sickle cell anemia (SCA) because significant oxidative stress occurs in the disease. Ascorbate could contribute to reduction of the increased oxygen free radicals generated in sickle red blood cells (SRBC) and to the recycling of vitamin E in the cells, while renal loss could contribute to the low plasma levels. Evaluation of red blood cell (RBC) and urine ascorbate in SCA has not been reported. Results showed (1) ascorbate levels in SRBC were similar to those in normals; (2) urine ascorbate excretion was increased in 36% of patients; (3) plasma levels of ascorbate were decreased. CONCLUSIONS: (1) Ascorbate is present in SRBC, most likely due to ascorbate recycling, despite increased free-radical generation. (2) The increase in renal excretion may contribute to the low plasma levels of ascorbate. (3) The presence of ample ascorbate in SRBC and decreased plasma ascorbate suggests that ascorbate movement across the SRBC membrane may differ from normal RBC. SN - 0361-8609 UR - https://www.unboundmedicine.com/medline/citation/10996838/full_citation L2 - http://www.diseaseinfosearch.org/result/441 DB - PRIME DP - Unbound Medicine ER -