Citation
Westerman, M P., et al. "Ascorbate Levels in Red Blood Cells and Urine in Patients With Sickle Cell Anemia." American Journal of Hematology, vol. 65, no. 2, 2000, pp. 174-5.
Westerman MP, Zhang Y, McConnell JP, et al. Ascorbate levels in red blood cells and urine in patients with sickle cell anemia. Am J Hematol. 2000;65(2):174-5.
Westerman, M. P., Zhang, Y., McConnell, J. P., Chezick, P. A., Neelam, R., Freels, S., Feldman, L. S., Allen, S., Baridi, R., Feldman, L. E., & Fung, L. W. (2000). Ascorbate levels in red blood cells and urine in patients with sickle cell anemia. American Journal of Hematology, 65(2), 174-5.
Westerman MP, et al. Ascorbate Levels in Red Blood Cells and Urine in Patients With Sickle Cell Anemia. Am J Hematol. 2000;65(2):174-5. PubMed PMID: 10996838.
TY - JOUR
T1 - Ascorbate levels in red blood cells and urine in patients with sickle cell anemia.
AU - Westerman,M P,
AU - Zhang,Y,
AU - McConnell,J P,
AU - Chezick,P A,
AU - Neelam,R,
AU - Freels,S,
AU - Feldman,L S,
AU - Allen,S,
AU - Baridi,R,
AU - Feldman,L E,
AU - Fung,L W,
PY - 2000/9/21/pubmed
PY - 2001/2/28/medline
PY - 2000/9/21/entrez
SP - 174
EP - 5
JF - American journal of hematology
JO - Am J Hematol
VL - 65
IS - 2
N2 - UNLABELLED: Ascorbic acid can be important in sickle cell anemia (SCA) because significant oxidative stress occurs in the disease. Ascorbate could contribute to reduction of the increased oxygen free radicals generated in sickle red blood cells (SRBC) and to the recycling of vitamin E in the cells, while renal loss could contribute to the low plasma levels. Evaluation of red blood cell (RBC) and urine ascorbate in SCA has not been reported. Results showed (1) ascorbate levels in SRBC were similar to those in normals; (2) urine ascorbate excretion was increased in 36% of patients; (3) plasma levels of ascorbate were decreased. CONCLUSIONS: (1) Ascorbate is present in SRBC, most likely due to ascorbate recycling, despite increased free-radical generation. (2) The increase in renal excretion may contribute to the low plasma levels of ascorbate. (3) The presence of ample ascorbate in SRBC and decreased plasma ascorbate suggests that ascorbate movement across the SRBC membrane may differ from normal RBC.
SN - 0361-8609
UR - https://www.unboundmedicine.com/medline/citation/10996838/full_citation
L2 - https://doi.org/10.1002/1096-8652(200010)65:2<174::aid-ajh15>3.0.co;2-t
DB - PRIME
DP - Unbound Medicine
ER -