Ascorbate levels in red blood cells and urine in patients with sickle cell anemia.
Abstract
Ascorbic acid can be important in sickle cell anemia (SCA) because significant oxidative stress occurs in the disease. Ascorbate could contribute to reduction of the increased oxygen free radicals generated in sickle red blood cells (SRBC) and to the recycling of vitamin E in the cells, while renal loss could contribute to the low plasma levels. Evaluation of red blood cell (RBC) and urine ascorbate in SCA has not been reported. Results showed (1) ascorbate levels in SRBC were similar to those in normals; (2) urine ascorbate excretion was increased in 36% of patients; (3) plasma levels of ascorbate were decreased.
CONCLUSIONS
(1) Ascorbate is present in SRBC, most likely due to ascorbate recycling, despite increased free-radical generation. (2) The increase in renal excretion may contribute to the low plasma levels of ascorbate. (3) The presence of ample ascorbate in SRBC and decreased plasma ascorbate suggests that ascorbate movement across the SRBC membrane may differ from normal RBC.Authors+Show Affiliations
,Department of Medicine, Mount Sinai Hospital Medical Center, Chicago, Illinois 60608, USA. wesm@sinai.org
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American journal of hematology 65:2 2000 Oct pg 174-5
MeSH
AdultAnemia, Sickle Cell
Ascorbic Acid
Erythrocytes
Humans
Matched-Pair Analysis
Middle Aged
Osmolar Concentration
Sodium
Pub Type(s)
Journal ArticleLanguage
eng
PubMed ID
10996838
Citation
* When formatting your citation, note that all book, journal, and database titles should be italicized* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Ascorbate levels in red blood cells and urine in patients with sickle cell anemia.
AU - Westerman,M P,
AU - Zhang,Y,
AU - McConnell,J P,
AU - Chezick,P A,
AU - Neelam,R,
AU - Freels,S,
AU - Feldman,L S,
AU - Allen,S,
AU - Baridi,R,
AU - Feldman,L E,
AU - Fung,L W,
PY - 2000/9/21/pubmed
PY - 2001/2/28/medline
PY - 2000/9/21/entrez
SP - 174
EP - 5
JF - American journal of hematology
JO - Am. J. Hematol.
VL - 65
IS - 2
N2 - UNLABELLED: Ascorbic acid can be important in sickle cell anemia (SCA) because significant oxidative stress occurs in the disease. Ascorbate could contribute to reduction of the increased oxygen free radicals generated in sickle red blood cells (SRBC) and to the recycling of vitamin E in the cells, while renal loss could contribute to the low plasma levels. Evaluation of red blood cell (RBC) and urine ascorbate in SCA has not been reported. Results showed (1) ascorbate levels in SRBC were similar to those in normals; (2) urine ascorbate excretion was increased in 36% of patients; (3) plasma levels of ascorbate were decreased. CONCLUSIONS: (1) Ascorbate is present in SRBC, most likely due to ascorbate recycling, despite increased free-radical generation. (2) The increase in renal excretion may contribute to the low plasma levels of ascorbate. (3) The presence of ample ascorbate in SRBC and decreased plasma ascorbate suggests that ascorbate movement across the SRBC membrane may differ from normal RBC.
SN - 0361-8609
UR - https://www.unboundmedicine.com/medline/citation/10996838/full_citation
L2 - http://www.diseaseinfosearch.org/result/441
DB - PRIME
DP - Unbound Medicine
ER -