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Prevalence of celiac disease in Down syndrome in the United States.
J Pediatr Gastroenterol Nutr 2000; 31(3):275-9JP

Abstract

BACKGROUND

Numerous studies in Europe have documented a high prevalence of celiac disease in Down syndrome. This study was undertaken to estimate the prevalence of celiac disease in Down syndrome in the southeastern United States.

METHODS

Seventy-five patients with Down syndrome were screened using immunoglobulin (Ig)A-anti antiendomysium antibodies, IgA-antigliadin antibodies, and total IgA level. When either antiendomysium or antigliadin antibodies produced positive findings, patients were referred to a pediatric gastroenterologist for consideration of a duodenal biopsy.

RESULTS

Thirteen percent (10/75) were positive for antiendomysium antibodies. Half of these patients were also positive for antigliadin antibodies. Six of 10 patients positive for antiendomysium antibodies underwent intestinal biopsy. Changes consistent with celiac disease were documented in five. Histologic findings ranged from focal to total villous atrophy. None had IgA deficiency.

CONCLUSIONS

There was a high prevalence of positivity to antiendomysium antibody in Down syndrome. Antiendomysium antibody was a more sensitive screening test than antigliadin antibody. The prevalence of celiac disease in Down syndrome in the southeastern United States was 1 in 14 cases. Screening with antiendomysium antibody and IgA for all children with Down syndrome is recommended, even if there are no gastrointestinal symptoms.

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    Authors+Show Affiliations

    Zachor DA
    Department of Pediatrics, University of Alabama at Birmingham, USA.
    Mroczek-Musulman E
    No affiliation info available
    Brown P
    No affiliation info available

    MeSH

    AdolescentAdultAutoantibodiesBiopsyCeliac DiseaseChildChild, PreschoolDown SyndromeDuodenumFemaleGliadinHumansImmunoglobulin AInfantMaleMyofibrilsPrevalenceSoutheastern United States

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    10997372

    Citation

    Zachor, D A., et al. "Prevalence of Celiac Disease in Down Syndrome in the United States." Journal of Pediatric Gastroenterology and Nutrition, vol. 31, no. 3, 2000, pp. 275-9.
    Zachor DA, Mroczek-Musulman E, Brown P. Prevalence of celiac disease in Down syndrome in the United States. J Pediatr Gastroenterol Nutr. 2000;31(3):275-9.
    Zachor, D. A., Mroczek-Musulman, E., & Brown, P. (2000). Prevalence of celiac disease in Down syndrome in the United States. Journal of Pediatric Gastroenterology and Nutrition, 31(3), pp. 275-9.
    Zachor DA, Mroczek-Musulman E, Brown P. Prevalence of Celiac Disease in Down Syndrome in the United States. J Pediatr Gastroenterol Nutr. 2000;31(3):275-9. PubMed PMID: 10997372.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Prevalence of celiac disease in Down syndrome in the United States. AU - Zachor,D A, AU - Mroczek-Musulman,E, AU - Brown,P, PY - 2000/9/21/pubmed PY - 2001/9/28/medline PY - 2000/9/21/entrez SP - 275 EP - 9 JF - Journal of pediatric gastroenterology and nutrition JO - J. Pediatr. Gastroenterol. Nutr. VL - 31 IS - 3 N2 - BACKGROUND: Numerous studies in Europe have documented a high prevalence of celiac disease in Down syndrome. This study was undertaken to estimate the prevalence of celiac disease in Down syndrome in the southeastern United States. METHODS: Seventy-five patients with Down syndrome were screened using immunoglobulin (Ig)A-anti antiendomysium antibodies, IgA-antigliadin antibodies, and total IgA level. When either antiendomysium or antigliadin antibodies produced positive findings, patients were referred to a pediatric gastroenterologist for consideration of a duodenal biopsy. RESULTS: Thirteen percent (10/75) were positive for antiendomysium antibodies. Half of these patients were also positive for antigliadin antibodies. Six of 10 patients positive for antiendomysium antibodies underwent intestinal biopsy. Changes consistent with celiac disease were documented in five. Histologic findings ranged from focal to total villous atrophy. None had IgA deficiency. CONCLUSIONS: There was a high prevalence of positivity to antiendomysium antibody in Down syndrome. Antiendomysium antibody was a more sensitive screening test than antigliadin antibody. The prevalence of celiac disease in Down syndrome in the southeastern United States was 1 in 14 cases. Screening with antiendomysium antibody and IgA for all children with Down syndrome is recommended, even if there are no gastrointestinal symptoms. SN - 0277-2116 UR - https://www.unboundmedicine.com/medline/citation/10997372/Prevalence_of_celiac_disease_in_Down_syndrome_in_the_United_States_ L2 - http://dx.doi.org/10.1097/00005176-200009000-00014 DB - PRIME DP - Unbound Medicine ER -