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No effect of glucagon-like peptide-1 on short-term satiety and energy intake in man.
Br J Nutr. 1999 Apr; 81(4):273-9.BJ

Abstract

Centrally administered glucagon-like peptide-1 (GLP-1) inhibits feeding in fasted rats, but its role in human satiety has been largely unexplored. The present study investigated the effect of peripheral GLP-1 infusion on gastric emptying and satiety in man. Ten non-obese male subjects were infused in a randomized single-blind within-subject crossover study using saline infusion as control. They received either a GLP-1 infusion (1.2 pmol/kg per min) or a saline infusion for 1 h, at 18.00 hours. At 20 min after starting the infusion the gastric emptying of a 400 ml water load was measured. Subjects completed behavioural self-rating scales to assess hunger and satiety. After 40 min subjects were given a buffet meal ad libitum and their food intake was recorded. GLP-1 infusion raised circulating GLP-1 concentrations to approximately twice those seen following a meal. It did not affect circulating insulin levels but caused a small fall in glucose levels. Gastric emptying of the water load was significantly delayed by the GLP-1 infusion. Energy intake from the buffet was unaffected by GLP-1 infusion. Self-assessment of hunger and satiety was similarly unaffected by the infusion before the buffet meal, although subjects tended to be less hungry after the buffet meal following GLP-1 infusion (P < 0.09). GLP-1 infusion delayed gastric emptying but had a minimal effect on food intake and satiety. This study casts doubts on whether GLP-1 is a major satiety factor in man, although a raised circulating plasma glucose level, as would normally occur postprandially, might be necessary for GLP-1 to increase satiety.

Authors+Show Affiliations

School of Biological Sciences, University of Surrey, Guildford, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10999014

Citation

Long, S J., et al. "No Effect of Glucagon-like Peptide-1 On Short-term Satiety and Energy Intake in Man." The British Journal of Nutrition, vol. 81, no. 4, 1999, pp. 273-9.
Long SJ, Sutton JA, Amaee WB, et al. No effect of glucagon-like peptide-1 on short-term satiety and energy intake in man. Br J Nutr. 1999;81(4):273-9.
Long, S. J., Sutton, J. A., Amaee, W. B., Giouvanoudi, A., Spyrou, N. M., Rogers, P. J., & Morgan, L. M. (1999). No effect of glucagon-like peptide-1 on short-term satiety and energy intake in man. The British Journal of Nutrition, 81(4), 273-9.
Long SJ, et al. No Effect of Glucagon-like Peptide-1 On Short-term Satiety and Energy Intake in Man. Br J Nutr. 1999;81(4):273-9. PubMed PMID: 10999014.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - No effect of glucagon-like peptide-1 on short-term satiety and energy intake in man. AU - Long,S J, AU - Sutton,J A, AU - Amaee,W B, AU - Giouvanoudi,A, AU - Spyrou,N M, AU - Rogers,P J, AU - Morgan,L M, PY - 2000/9/22/pubmed PY - 2000/9/30/medline PY - 2000/9/22/entrez SP - 273 EP - 9 JF - The British journal of nutrition JO - Br J Nutr VL - 81 IS - 4 N2 - Centrally administered glucagon-like peptide-1 (GLP-1) inhibits feeding in fasted rats, but its role in human satiety has been largely unexplored. The present study investigated the effect of peripheral GLP-1 infusion on gastric emptying and satiety in man. Ten non-obese male subjects were infused in a randomized single-blind within-subject crossover study using saline infusion as control. They received either a GLP-1 infusion (1.2 pmol/kg per min) or a saline infusion for 1 h, at 18.00 hours. At 20 min after starting the infusion the gastric emptying of a 400 ml water load was measured. Subjects completed behavioural self-rating scales to assess hunger and satiety. After 40 min subjects were given a buffet meal ad libitum and their food intake was recorded. GLP-1 infusion raised circulating GLP-1 concentrations to approximately twice those seen following a meal. It did not affect circulating insulin levels but caused a small fall in glucose levels. Gastric emptying of the water load was significantly delayed by the GLP-1 infusion. Energy intake from the buffet was unaffected by GLP-1 infusion. Self-assessment of hunger and satiety was similarly unaffected by the infusion before the buffet meal, although subjects tended to be less hungry after the buffet meal following GLP-1 infusion (P < 0.09). GLP-1 infusion delayed gastric emptying but had a minimal effect on food intake and satiety. This study casts doubts on whether GLP-1 is a major satiety factor in man, although a raised circulating plasma glucose level, as would normally occur postprandially, might be necessary for GLP-1 to increase satiety. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/10999014/No_effect_of_glucagon_like_peptide_1_on_short_term_satiety_and_energy_intake_in_man_ L2 - https://www.cambridge.org/core/product/identifier/S0007114599000513/type/journal_article DB - PRIME DP - Unbound Medicine ER -