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Effect of calcium or 25OH vitamin D3 dietary supplementation on bone loss at the hip in men and women over the age of 60.
J Clin Endocrinol Metab 2000; 85(9):3011-9JC

Abstract

Dietary supplements that prevent bone loss at the hip and that can be applied safely in the elderly are likely to reduce hip fractures. A daily dietary supplement of 750 mg calcium or 15 microg 25OH vitamin D3 on bone loss at the hip and other sites, bone turnover and calcium-regulating hormones were studied over 4 yr in elderly volunteers using a randomized, double-blind, placebo-controlled trial. Bone mineral density (BMD) was measured by dual x-ray absorptiometry and bone structure by radiographs. Calcium biochemistry and bone turnover markers were measured in blood and urine. The 316 women entering the trial had a mean age of 73.7 yr and the 122 men of 75.9 yr. Baseline median calcium intake was 546 mg/day, and median serum 25OH vitamin D3 was 59 nmol/L. On placebo, loss of BMD at total hip was 2% and femoral medulla expansion was 3% over 4 yr. Calcium reduced bone loss, secondary hyperparathyroidism, and bone turnover. 25OH vitamin D3 was intermediate between placebo and calcium. Fracture rates and drop-out rates were similar among groups, and there were no serious adverse events with either supplement. A calcium supplement of 750 mg/day prevents loss of BMD, reduces femoral medullary expansion, secondary hyperparathyroidism, and high bone turnover. A supplement of 15 microg/day 25OH vitamin D3 is less effective, and because its effects are seen only at low calcium intakes, suggests that its beneficial effect is to reverse calcium insufficiency.

Authors+Show Affiliations

Department of Medicine, Indiana University School of Medicine, Indianapolis 46202, USA.

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10999778

Citation

Peacock, M, et al. "Effect of Calcium or 25OH Vitamin D3 Dietary Supplementation On Bone Loss at the Hip in Men and Women Over the Age of 60." The Journal of Clinical Endocrinology and Metabolism, vol. 85, no. 9, 2000, pp. 3011-9.
Peacock M, Liu G, Carey M, et al. Effect of calcium or 25OH vitamin D3 dietary supplementation on bone loss at the hip in men and women over the age of 60. J Clin Endocrinol Metab. 2000;85(9):3011-9.
Peacock, M., Liu, G., Carey, M., McClintock, R., Ambrosius, W., Hui, S., & Johnston, C. C. (2000). Effect of calcium or 25OH vitamin D3 dietary supplementation on bone loss at the hip in men and women over the age of 60. The Journal of Clinical Endocrinology and Metabolism, 85(9), pp. 3011-9.
Peacock M, et al. Effect of Calcium or 25OH Vitamin D3 Dietary Supplementation On Bone Loss at the Hip in Men and Women Over the Age of 60. J Clin Endocrinol Metab. 2000;85(9):3011-9. PubMed PMID: 10999778.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of calcium or 25OH vitamin D3 dietary supplementation on bone loss at the hip in men and women over the age of 60. AU - Peacock,M, AU - Liu,G, AU - Carey,M, AU - McClintock,R, AU - Ambrosius,W, AU - Hui,S, AU - Johnston,C C, PY - 2000/9/22/pubmed PY - 2000/10/21/medline PY - 2000/9/22/entrez SP - 3011 EP - 9 JF - The Journal of clinical endocrinology and metabolism JO - J. Clin. Endocrinol. Metab. VL - 85 IS - 9 N2 - Dietary supplements that prevent bone loss at the hip and that can be applied safely in the elderly are likely to reduce hip fractures. A daily dietary supplement of 750 mg calcium or 15 microg 25OH vitamin D3 on bone loss at the hip and other sites, bone turnover and calcium-regulating hormones were studied over 4 yr in elderly volunteers using a randomized, double-blind, placebo-controlled trial. Bone mineral density (BMD) was measured by dual x-ray absorptiometry and bone structure by radiographs. Calcium biochemistry and bone turnover markers were measured in blood and urine. The 316 women entering the trial had a mean age of 73.7 yr and the 122 men of 75.9 yr. Baseline median calcium intake was 546 mg/day, and median serum 25OH vitamin D3 was 59 nmol/L. On placebo, loss of BMD at total hip was 2% and femoral medulla expansion was 3% over 4 yr. Calcium reduced bone loss, secondary hyperparathyroidism, and bone turnover. 25OH vitamin D3 was intermediate between placebo and calcium. Fracture rates and drop-out rates were similar among groups, and there were no serious adverse events with either supplement. A calcium supplement of 750 mg/day prevents loss of BMD, reduces femoral medullary expansion, secondary hyperparathyroidism, and high bone turnover. A supplement of 15 microg/day 25OH vitamin D3 is less effective, and because its effects are seen only at low calcium intakes, suggests that its beneficial effect is to reverse calcium insufficiency. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/10999778/Effect_of_calcium_or_25OH_vitamin_D3_dietary_supplementation_on_bone_loss_at_the_hip_in_men_and_women_over_the_age_of_60_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem.85.9.6836 DB - PRIME DP - Unbound Medicine ER -