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Type 1-like immune response is found in children with respiratory syncytial virus infection regardless of clinical severity.
J Med Virol. 2000 Oct; 62(2):267-77.JM

Abstract

The immunological response of infants younger than six months to infection with respiratory syncytial virus (RSV) was studied in relation to clinical severity. IL-6 and IL-8 were found more frequently and at higher levels in the plasma samples of more severely ill patients and no significant differences were found in the levels of cytokines differentiating between Type 1 and Type 2 responses. Cellular infiltrates in nasopharyngeal washings consisted mainly of polymorphonuclear granulocytes and monocytes. Eosinophils, IgE positive cells and tryptase positive cells were found sporadically. Analyses of RSV stimulated T cell cultures established from peripheral blood mononuclear cells, for intracellular and secreted cytokines showed that, irrespective of clinical severity, the responses were dominated by the production of IFN-gamma, and that only low levels of IL-4 and IL-10 were detectable. Collectively these data do not indicate an association between clinical severity and a Type 2-like T cell response.

Authors+Show Affiliations

Institute of Virology, Erasmus University Rotterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11002258

Citation

Brandenburg, A H., et al. "Type 1-like Immune Response Is Found in Children With Respiratory Syncytial Virus Infection Regardless of Clinical Severity." Journal of Medical Virology, vol. 62, no. 2, 2000, pp. 267-77.
Brandenburg AH, Kleinjan A, van Het Land B, et al. Type 1-like immune response is found in children with respiratory syncytial virus infection regardless of clinical severity. J Med Virol. 2000;62(2):267-77.
Brandenburg, A. H., Kleinjan, A., van Het Land, B., Moll, H. A., Timmerman, H. H., de Swart, R. L., Neijens, H. J., Fokkens, W., & Osterhaus, A. D. (2000). Type 1-like immune response is found in children with respiratory syncytial virus infection regardless of clinical severity. Journal of Medical Virology, 62(2), 267-77.
Brandenburg AH, et al. Type 1-like Immune Response Is Found in Children With Respiratory Syncytial Virus Infection Regardless of Clinical Severity. J Med Virol. 2000;62(2):267-77. PubMed PMID: 11002258.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Type 1-like immune response is found in children with respiratory syncytial virus infection regardless of clinical severity. AU - Brandenburg,A H, AU - Kleinjan,A, AU - van Het Land,B, AU - Moll,H A, AU - Timmerman,H H, AU - de Swart,R L, AU - Neijens,H J, AU - Fokkens,W, AU - Osterhaus,A D, PY - 2000/9/26/pubmed PY - 2001/2/28/medline PY - 2000/9/26/entrez SP - 267 EP - 77 JF - Journal of medical virology JO - J Med Virol VL - 62 IS - 2 N2 - The immunological response of infants younger than six months to infection with respiratory syncytial virus (RSV) was studied in relation to clinical severity. IL-6 and IL-8 were found more frequently and at higher levels in the plasma samples of more severely ill patients and no significant differences were found in the levels of cytokines differentiating between Type 1 and Type 2 responses. Cellular infiltrates in nasopharyngeal washings consisted mainly of polymorphonuclear granulocytes and monocytes. Eosinophils, IgE positive cells and tryptase positive cells were found sporadically. Analyses of RSV stimulated T cell cultures established from peripheral blood mononuclear cells, for intracellular and secreted cytokines showed that, irrespective of clinical severity, the responses were dominated by the production of IFN-gamma, and that only low levels of IL-4 and IL-10 were detectable. Collectively these data do not indicate an association between clinical severity and a Type 2-like T cell response. SN - 0146-6615 UR - https://www.unboundmedicine.com/medline/citation/11002258/Type_1_like_immune_response_is_found_in_children_with_respiratory_syncytial_virus_infection_regardless_of_clinical_severity_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0146-6615&date=2000&volume=62&issue=2&spage=267 DB - PRIME DP - Unbound Medicine ER -