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Norepinephrine reuptake, baroreflex dynamics, and arterial pressure variability in rats.
Am J Physiol Regul Integr Comp Physiol. 2000 Oct; 279(4):R1257-67.AJ

Abstract

This study examined the effect of norepinephrine reuptake blockade with desipramine (DMI) on the spontaneous variability of the simultaneously recorded arterial pressure (AP) and renal sympathetic nerve activity (SNA) in conscious rats. Acute DMI administration (2 mg/kg iv) depressed AP Mayer waves (approximately 0.4 Hz) and increased low-frequency (<0.2 Hz) components of AP variability. DMI decreased renal SNA variability, especially due to the abolition of oscillations related to Mayer waves. To examine whether DMI-induced changes in AP and renal SNA variabilities could be explained by alterations in the dynamic characteristics of the baroreceptor reflex loop, the frequency responses of mean AP to aortic depressor nerve stimulation were studied in urethan-anesthetized rats. DMI accentuated the low-pass filter properties of the transfer function without significantly altering the fixed time delay. The frequency responses of iliac vascular conductance to stimulation of the lumbar sympathetic chain were studied in an additional group of anesthetized rats. DMI did not markedly alter the low-pass filter properties of the transfer function and slightly increased the fixed time delay. These results suggest that the DMI-induced decrease in the dynamic gain of the baroreceptor reflex is responsible for the decreased spontaneous renal SNA variability and the accompanying increased AP variability. The "slowing down" of baroreflex responses cannot be attributed to an effect of DMI at the vascular neuroeffector junction.

Authors+Show Affiliations

Département de Physiologie et Pharmacologie Clinique, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5014, Faculté de Pharmacie, Lyon, 69373 France. bertram@rockefeller.univ-lyon1.frNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11003991

Citation

Bertram, D, et al. "Norepinephrine Reuptake, Baroreflex Dynamics, and Arterial Pressure Variability in Rats." American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, vol. 279, no. 4, 2000, pp. R1257-67.
Bertram D, Barrès C, Cheng Y, et al. Norepinephrine reuptake, baroreflex dynamics, and arterial pressure variability in rats. Am J Physiol Regul Integr Comp Physiol. 2000;279(4):R1257-67.
Bertram, D., Barrès, C., Cheng, Y., & Julien, C. (2000). Norepinephrine reuptake, baroreflex dynamics, and arterial pressure variability in rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 279(4), R1257-67.
Bertram D, et al. Norepinephrine Reuptake, Baroreflex Dynamics, and Arterial Pressure Variability in Rats. Am J Physiol Regul Integr Comp Physiol. 2000;279(4):R1257-67. PubMed PMID: 11003991.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Norepinephrine reuptake, baroreflex dynamics, and arterial pressure variability in rats. AU - Bertram,D, AU - Barrès,C, AU - Cheng,Y, AU - Julien,C, PY - 2000/9/27/pubmed PY - 2001/2/28/medline PY - 2000/9/27/entrez SP - R1257 EP - 67 JF - American journal of physiology. Regulatory, integrative and comparative physiology JO - Am. J. Physiol. Regul. Integr. Comp. Physiol. VL - 279 IS - 4 N2 - This study examined the effect of norepinephrine reuptake blockade with desipramine (DMI) on the spontaneous variability of the simultaneously recorded arterial pressure (AP) and renal sympathetic nerve activity (SNA) in conscious rats. Acute DMI administration (2 mg/kg iv) depressed AP Mayer waves (approximately 0.4 Hz) and increased low-frequency (<0.2 Hz) components of AP variability. DMI decreased renal SNA variability, especially due to the abolition of oscillations related to Mayer waves. To examine whether DMI-induced changes in AP and renal SNA variabilities could be explained by alterations in the dynamic characteristics of the baroreceptor reflex loop, the frequency responses of mean AP to aortic depressor nerve stimulation were studied in urethan-anesthetized rats. DMI accentuated the low-pass filter properties of the transfer function without significantly altering the fixed time delay. The frequency responses of iliac vascular conductance to stimulation of the lumbar sympathetic chain were studied in an additional group of anesthetized rats. DMI did not markedly alter the low-pass filter properties of the transfer function and slightly increased the fixed time delay. These results suggest that the DMI-induced decrease in the dynamic gain of the baroreceptor reflex is responsible for the decreased spontaneous renal SNA variability and the accompanying increased AP variability. The "slowing down" of baroreflex responses cannot be attributed to an effect of DMI at the vascular neuroeffector junction. SN - 0363-6119 UR - https://www.unboundmedicine.com/medline/citation/11003991/Norepinephrine_reuptake_baroreflex_dynamics_and_arterial_pressure_variability_in_rats_ L2 - http://journals.physiology.org/doi/full/10.1152/ajpregu.2000.279.4.R1257?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -