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Effect of MTHFR 1298A-->C and MTHFR 677C-->T genotypes on total homocysteine, folate, and vitamin B(12) plasma concentrations in kdiney graft recipients.
J Am Soc Nephrol 2000; 11(10):1918-25JA

Abstract

The effect of 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C-->T and 1298A-->C on total homocysteine (tHcy), folate and vitamin B(12) levels was investigated in 733 kidney graft recipients. The six major genotype combinations were used as grouping variables, and age, gender, BMI, serum creatinine, and creatinine clearance and ln-folate, ln-vitamin B(12), or logarithmus naturalis tHcy (ln-tHcy) were used as covariates in three ANCOVA and multiple stepwise linear regression models. Hyperhomocysteinemia was present in 49.7% of the patients. The allele frequency of MTHFR 677T and 1298C was 0.319 and 0.326. MTHFR genotype and all other variables were significant predictors of ln-tHcy (higher tHcy plasma levels for MTHFR 677TT/1298AA versus all other five genotype groups: P < 0. 05). BMI, creatinine clearance, ln-tHcy, and MTHFR genotype influenced ln-folate (lower folate levels for MTHFR 677TT/1298AA versus all other genotype groups: P < 0.05). Creatinine clearance and ln-tHcy were the only predictors of ln-vitamin B(12) levels. In a prespecified subgroup analysis (n = 496), the MTHFR genotype also influenced tHcy levels and compound heterozygous patients had significantly lower folate levels as compared with MTHFR 677CC/1298AA and 677CC/1298CC. This study shows that the MTHFR 677TT/1298AA and 677CT/1298AC genotypes are significant predictors of tHcy and folate plasma levels.

Authors+Show Affiliations

Department of Laboratory Medicine, Division of Molecular Biology, University of Vienna, Austria.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11004224

Citation

Födinger, M, et al. "Effect of MTHFR 1298A-->C and MTHFR 677C-->T Genotypes On Total Homocysteine, Folate, and Vitamin B(12) Plasma Concentrations in Kdiney Graft Recipients." Journal of the American Society of Nephrology : JASN, vol. 11, no. 10, 2000, pp. 1918-25.
Födinger M, Buchmayer H, Heinz G, et al. Effect of MTHFR 1298A-->C and MTHFR 677C-->T genotypes on total homocysteine, folate, and vitamin B(12) plasma concentrations in kdiney graft recipients. J Am Soc Nephrol. 2000;11(10):1918-25.
Födinger, M., Buchmayer, H., Heinz, G., Papagiannopoulos, M., Kletzmayr, J., Rasoul-Rockenschaub, S., ... Sunder-Plassmann, G. (2000). Effect of MTHFR 1298A-->C and MTHFR 677C-->T genotypes on total homocysteine, folate, and vitamin B(12) plasma concentrations in kdiney graft recipients. Journal of the American Society of Nephrology : JASN, 11(10), pp. 1918-25.
Födinger M, et al. Effect of MTHFR 1298A-->C and MTHFR 677C-->T Genotypes On Total Homocysteine, Folate, and Vitamin B(12) Plasma Concentrations in Kdiney Graft Recipients. J Am Soc Nephrol. 2000;11(10):1918-25. PubMed PMID: 11004224.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of MTHFR 1298A-->C and MTHFR 677C-->T genotypes on total homocysteine, folate, and vitamin B(12) plasma concentrations in kdiney graft recipients. AU - Födinger,M, AU - Buchmayer,H, AU - Heinz,G, AU - Papagiannopoulos,M, AU - Kletzmayr,J, AU - Rasoul-Rockenschaub,S, AU - Hörl,W H, AU - Sunder-Plassmann,G, PY - 2000/9/27/pubmed PY - 2001/2/28/medline PY - 2000/9/27/entrez SP - 1918 EP - 25 JF - Journal of the American Society of Nephrology : JASN JO - J. Am. Soc. Nephrol. VL - 11 IS - 10 N2 - The effect of 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C-->T and 1298A-->C on total homocysteine (tHcy), folate and vitamin B(12) levels was investigated in 733 kidney graft recipients. The six major genotype combinations were used as grouping variables, and age, gender, BMI, serum creatinine, and creatinine clearance and ln-folate, ln-vitamin B(12), or logarithmus naturalis tHcy (ln-tHcy) were used as covariates in three ANCOVA and multiple stepwise linear regression models. Hyperhomocysteinemia was present in 49.7% of the patients. The allele frequency of MTHFR 677T and 1298C was 0.319 and 0.326. MTHFR genotype and all other variables were significant predictors of ln-tHcy (higher tHcy plasma levels for MTHFR 677TT/1298AA versus all other five genotype groups: P < 0. 05). BMI, creatinine clearance, ln-tHcy, and MTHFR genotype influenced ln-folate (lower folate levels for MTHFR 677TT/1298AA versus all other genotype groups: P < 0.05). Creatinine clearance and ln-tHcy were the only predictors of ln-vitamin B(12) levels. In a prespecified subgroup analysis (n = 496), the MTHFR genotype also influenced tHcy levels and compound heterozygous patients had significantly lower folate levels as compared with MTHFR 677CC/1298AA and 677CC/1298CC. This study shows that the MTHFR 677TT/1298AA and 677CT/1298AC genotypes are significant predictors of tHcy and folate plasma levels. SN - 1046-6673 UR - https://www.unboundmedicine.com/medline/citation/11004224/Effect_of_MTHFR_1298A__>C_and_MTHFR_677C__>T_genotypes_on_total_homocysteine_folate_and_vitamin_B_12__plasma_concentrations_in_kdiney_graft_recipients_ L2 - http://jasn.asnjournals.org/cgi/pmidlookup?view=long&amp;pmid=11004224 DB - PRIME DP - Unbound Medicine ER -