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[Comparison between histamine H2-blocker and proton pump inhibitor on the effects of initial treatment in reflux esophagitis].
Nihon Rinsho. 2000 Sep; 58(9):1847-52.NR

Abstract

I have reviewed the comparison between histamine H2 blocker(H2-RA) and proton pump inhibitor(PPI) on the effects of initial treatment in patients with reflux esophagitis. Pathophysiology of reflux esophagitis has been thought to be gastroesophageal reflux of the gastric acid, due to motor dysfunctions of the esophagus and the stomach. Endoscopic healing rate of reflux esophagitis is significantly higher 84% on PPI treatment than 52% on H2-RA treatment at 8 weeks period. Because suppression of the gastric acid secretion is significantly stronger and longer on PPI than H2-RA, especially this suppression is markedly found in day time and also night time. On the initial treatment of reflux esophagitis, PPI is choice so-called "step down therapy" after healing, H2-RA and/or prokinetic drugs are treated as maintenance therapy.

Authors+Show Affiliations

Saitama-Ken Saiseikai Kawaguchi General Hospital.

Pub Type(s)

Comparative Study
English Abstract
Journal Article
Review

Language

jpn

PubMed ID

11004814

Citation

Harasawa, S. "[Comparison Between Histamine H2-blocker and Proton Pump Inhibitor On the Effects of Initial Treatment in Reflux Esophagitis]." Nihon Rinsho. Japanese Journal of Clinical Medicine, vol. 58, no. 9, 2000, pp. 1847-52.
Harasawa S. [Comparison between histamine H2-blocker and proton pump inhibitor on the effects of initial treatment in reflux esophagitis]. Nippon Rinsho. 2000;58(9):1847-52.
Harasawa, S. (2000). [Comparison between histamine H2-blocker and proton pump inhibitor on the effects of initial treatment in reflux esophagitis]. Nihon Rinsho. Japanese Journal of Clinical Medicine, 58(9), 1847-52.
Harasawa S. [Comparison Between Histamine H2-blocker and Proton Pump Inhibitor On the Effects of Initial Treatment in Reflux Esophagitis]. Nippon Rinsho. 2000;58(9):1847-52. PubMed PMID: 11004814.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Comparison between histamine H2-blocker and proton pump inhibitor on the effects of initial treatment in reflux esophagitis]. A1 - Harasawa,S, PY - 2000/9/27/pubmed PY - 2001/2/28/medline PY - 2000/9/27/entrez SP - 1847 EP - 52 JF - Nihon rinsho. Japanese journal of clinical medicine JO - Nippon Rinsho VL - 58 IS - 9 N2 - I have reviewed the comparison between histamine H2 blocker(H2-RA) and proton pump inhibitor(PPI) on the effects of initial treatment in patients with reflux esophagitis. Pathophysiology of reflux esophagitis has been thought to be gastroesophageal reflux of the gastric acid, due to motor dysfunctions of the esophagus and the stomach. Endoscopic healing rate of reflux esophagitis is significantly higher 84% on PPI treatment than 52% on H2-RA treatment at 8 weeks period. Because suppression of the gastric acid secretion is significantly stronger and longer on PPI than H2-RA, especially this suppression is markedly found in day time and also night time. On the initial treatment of reflux esophagitis, PPI is choice so-called "step down therapy" after healing, H2-RA and/or prokinetic drugs are treated as maintenance therapy. SN - 0047-1852 UR - https://www.unboundmedicine.com/medline/citation/11004814/[Comparison_between_histamine_H2_blocker_and_proton_pump_inhibitor_on_the_effects_of_initial_treatment_in_reflux_esophagitis]_ DB - PRIME DP - Unbound Medicine ER -
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