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Age as a prognostic factor for recurrence in patients with endometrial carcinoma.

Abstract

PURPOSE

The aim of this study was to evaluate age as a prognostic factor for recurrence in endometrial cancer patients treated with primary surgery.

METHODS

Between 1983 and 1998, 455 endometrial cancer patients underwent primary surgery at our institution. Patients were divided into three age groups based on age at diagnosis: Group A (age <60, n = 156), B (age 60-69, n = 147), and C (age >/=70, n = 152). Clinicopathologic, treatment factors, and outcome were compared among the three groups. Prognostic factors were evaluated by univariate and multivariate analysis.

RESULTS

The three age groups had a similar distribution of most pathologic features including stage, histology, cervical involvement, positive cytology, adnexal involvement, nodal metastases, serosal involvement, and lymphovascular invasion (LVI). Older women had a higher rate, however, of deep (>1/2) myometrial invasion (P < 0.0001) and grade 3 tumors (P < 0.0001). The extent of surgical staging and use of adjuvant radiation therapy were similar. Five-year disease-free survivals (DFS) of Groups A, B, and C were 74.3, 70.2, and 60.3%, respectively (P = 0.08). A significant difference in DFS was seen when Groups A and B were combined and compared with Group C (72.0 vs 60.3%, P = 0.03). Multivariate analysis confirmed the significance of race, stage, grade, and LVI. Age was not found to be associated with recurrence (HR 1.1, 95% C.I. 0.91-1.5, P = 0.21).

CONCLUSION

Our results reveal that, in a large cohort of comparably staged and treated endometrial carcinoma patients, age is not a prognostic factor for recurrence.

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  • Authors+Show Affiliations

    ,

    Department of Radiation and Cellular Oncology, University of Chicago Hospitals, Chicago, Illinois 60637, USA. mundt@rover.uchicago.edu

    , , ,

    Source

    Gynecologic oncology 79:1 2000 Oct pg 79-85

    MeSH

    Age Factors
    Aged
    Chemotherapy, Adjuvant
    Cohort Studies
    Endometrial Neoplasms
    Female
    Humans
    Middle Aged
    Multivariate Analysis
    Neoplasm Recurrence, Local
    Prognosis
    Radiotherapy, Adjuvant
    Treatment Outcome

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    11006036

    Citation

    Mundt, A J., et al. "Age as a Prognostic Factor for Recurrence in Patients With Endometrial Carcinoma." Gynecologic Oncology, vol. 79, no. 1, 2000, pp. 79-85.
    Mundt AJ, Waggoner S, Yamada D, et al. Age as a prognostic factor for recurrence in patients with endometrial carcinoma. Gynecol Oncol. 2000;79(1):79-85.
    Mundt, A. J., Waggoner, S., Yamada, D., Rotmensch, J., & Connell, P. P. (2000). Age as a prognostic factor for recurrence in patients with endometrial carcinoma. Gynecologic Oncology, 79(1), pp. 79-85.
    Mundt AJ, et al. Age as a Prognostic Factor for Recurrence in Patients With Endometrial Carcinoma. Gynecol Oncol. 2000;79(1):79-85. PubMed PMID: 11006036.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Age as a prognostic factor for recurrence in patients with endometrial carcinoma. AU - Mundt,A J, AU - Waggoner,S, AU - Yamada,D, AU - Rotmensch,J, AU - Connell,P P, PY - 2000/9/28/pubmed PY - 2001/2/28/medline PY - 2000/9/28/entrez SP - 79 EP - 85 JF - Gynecologic oncology JO - Gynecol. Oncol. VL - 79 IS - 1 N2 - PURPOSE: The aim of this study was to evaluate age as a prognostic factor for recurrence in endometrial cancer patients treated with primary surgery. METHODS: Between 1983 and 1998, 455 endometrial cancer patients underwent primary surgery at our institution. Patients were divided into three age groups based on age at diagnosis: Group A (age <60, n = 156), B (age 60-69, n = 147), and C (age >/=70, n = 152). Clinicopathologic, treatment factors, and outcome were compared among the three groups. Prognostic factors were evaluated by univariate and multivariate analysis. RESULTS: The three age groups had a similar distribution of most pathologic features including stage, histology, cervical involvement, positive cytology, adnexal involvement, nodal metastases, serosal involvement, and lymphovascular invasion (LVI). Older women had a higher rate, however, of deep (>1/2) myometrial invasion (P < 0.0001) and grade 3 tumors (P < 0.0001). The extent of surgical staging and use of adjuvant radiation therapy were similar. Five-year disease-free survivals (DFS) of Groups A, B, and C were 74.3, 70.2, and 60.3%, respectively (P = 0.08). A significant difference in DFS was seen when Groups A and B were combined and compared with Group C (72.0 vs 60.3%, P = 0.03). Multivariate analysis confirmed the significance of race, stage, grade, and LVI. Age was not found to be associated with recurrence (HR 1.1, 95% C.I. 0.91-1.5, P = 0.21). CONCLUSION: Our results reveal that, in a large cohort of comparably staged and treated endometrial carcinoma patients, age is not a prognostic factor for recurrence. SN - 0090-8258 UR - https://www.unboundmedicine.com/medline/citation/11006036/Age_as_a_prognostic_factor_for_recurrence_in_patients_with_endometrial_carcinoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-8258(00)95917-1 DB - PRIME DP - Unbound Medicine ER -