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Evidence for the coordinate control of glycogen synthesis, glucose utilization, and glycolysis in Escherichia coli. I. Quantitative covariance of the rate of glucose utilization and the cellular level of fructose 1,6-diphosphate during exponential growth and nutrient limitation.
J Biol Chem. 1975 Sep 25; 250(18):7188-93.JB

Abstract

In cultures of Escherichia coli W4597(K) and G34 under various nutritional conditions the rates of glucose utilization and cellular levels of fructose-1,6-P2 are quantitatively related by the Hill equation where the value of the Hill coefficient is approximately equal to 2. This is the first evidence that fructose-P2, or any metabolite which covaries with fructose-P2, modulates glucose utilization in E. coli. In light of previous observations from our laboratory this new observation and those in the succeeding report provide the first evidence that in E. coli glycolysis, glycogen synthesis and glucose utilization are coordinately regulated, thus providing for the coupling of ATP utilization and production under various metabolic circumstances. Alterations in the level of ATP apparently affect the velocity of phosphofructokinase, the rate-limiting enzyme in glycolysis, altering the cellular levels of glucose-6-P or fructose-P2. Changes in the levels of these hexose phosphates are quantitatively related to alterations in the rates of glucose utilization and glycogen synthesis in the intact E. coli cell.

Authors

Dietzler DN
No affiliation info available
Leckie MP
No affiliation info available
Bergstein PE
No affiliation info available
Sughrue MJ
No affiliation info available

MeSH

Adenosine TriphosphateAmmoniaCell DivisionCulture MediaEscherichia coliFructosephosphatesGlucoseGlucosephosphatesGlycogenGlycolysisKineticsMathematicsSpecies SpecificityThreonine

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1100622

Citation

Dietzler, D N., et al. "Evidence for the Coordinate Control of Glycogen Synthesis, Glucose Utilization, and Glycolysis in Escherichia Coli. I. Quantitative Covariance of the Rate of Glucose Utilization and the Cellular Level of Fructose 1,6-diphosphate During Exponential Growth and Nutrient Limitation." The Journal of Biological Chemistry, vol. 250, no. 18, 1975, pp. 7188-93.
Dietzler DN, Leckie MP, Bergstein PE, et al. Evidence for the coordinate control of glycogen synthesis, glucose utilization, and glycolysis in Escherichia coli. I. Quantitative covariance of the rate of glucose utilization and the cellular level of fructose 1,6-diphosphate during exponential growth and nutrient limitation. J Biol Chem. 1975;250(18):7188-93.
Dietzler, D. N., Leckie, M. P., Bergstein, P. E., & Sughrue, M. J. (1975). Evidence for the coordinate control of glycogen synthesis, glucose utilization, and glycolysis in Escherichia coli. I. Quantitative covariance of the rate of glucose utilization and the cellular level of fructose 1,6-diphosphate during exponential growth and nutrient limitation. The Journal of Biological Chemistry, 250(18), 7188-93.
Dietzler DN, et al. Evidence for the Coordinate Control of Glycogen Synthesis, Glucose Utilization, and Glycolysis in Escherichia Coli. I. Quantitative Covariance of the Rate of Glucose Utilization and the Cellular Level of Fructose 1,6-diphosphate During Exponential Growth and Nutrient Limitation. J Biol Chem. 1975 Sep 25;250(18):7188-93. PubMed PMID: 1100622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence for the coordinate control of glycogen synthesis, glucose utilization, and glycolysis in Escherichia coli. I. Quantitative covariance of the rate of glucose utilization and the cellular level of fructose 1,6-diphosphate during exponential growth and nutrient limitation. AU - Dietzler,D N, AU - Leckie,M P, AU - Bergstein,P E, AU - Sughrue,M J, PY - 1975/9/25/pubmed PY - 1975/9/25/medline PY - 1975/9/25/entrez SP - 7188 EP - 93 JF - The Journal of biological chemistry JO - J Biol Chem VL - 250 IS - 18 N2 - In cultures of Escherichia coli W4597(K) and G34 under various nutritional conditions the rates of glucose utilization and cellular levels of fructose-1,6-P2 are quantitatively related by the Hill equation where the value of the Hill coefficient is approximately equal to 2. This is the first evidence that fructose-P2, or any metabolite which covaries with fructose-P2, modulates glucose utilization in E. coli. In light of previous observations from our laboratory this new observation and those in the succeeding report provide the first evidence that in E. coli glycolysis, glycogen synthesis and glucose utilization are coordinately regulated, thus providing for the coupling of ATP utilization and production under various metabolic circumstances. Alterations in the level of ATP apparently affect the velocity of phosphofructokinase, the rate-limiting enzyme in glycolysis, altering the cellular levels of glucose-6-P or fructose-P2. Changes in the levels of these hexose phosphates are quantitatively related to alterations in the rates of glucose utilization and glycogen synthesis in the intact E. coli cell. SN - 0021-9258 UR - https://www.unboundmedicine.com/medline/citation/1100622/Evidence_for_the_coordinate_control_of_glycogen_synthesis_glucose_utilization_and_glycolysis_in_Escherichia_coli__I__Quantitative_covariance_of_the_rate_of_glucose_utilization_and_the_cellular_level_of_fructose_16_diphosphate_during_exponential_growth_and_nutrient_limitation_ DB - PRIME DP - Unbound Medicine ER -
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